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Limbitrol DS Side Effects

Generic Name: amitriptyline / chlordiazepoxide

Note: This document contains side effect information about amitriptyline / chlordiazepoxide. Some of the dosage forms listed on this page may not apply to the brand name Limbitrol DS.

For the Consumer

Applies to amitriptyline / chlordiazepoxide: oral tablet

Along with its needed effects, amitriptyline/chlordiazepoxide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking amitriptyline / chlordiazepoxide:

Less common
  • Blurred vision or other changes in vision
  • confusion or hallucinations (seeing, hearing, or feeling things that are not there)
  • constipation
  • difficulty in urinating
  • eye pain
  • fainting
  • irregular heartbeat
  • mental depression
  • shakiness
  • trouble in sleeping
  • unusual excitement, nervousness, or irritability
Rare Symptoms of overdose
  • Agitation
  • confusion
  • convulsions (seizures)
  • dizziness or lightheadedness (severe)
  • drowsiness (severe)
  • enlarged pupils
  • fast or irregular heartbeat
  • fever
  • hallucinations
  • muscle stiffness or rigidity
  • vomiting (severe)

Some side effects of amitriptyline / chlordiazepoxide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bloating
  • clumsiness or unsteadiness
  • dizziness or lightheadedness
  • drowsiness
  • dryness of mouth or unpleasant taste
  • headache
  • weight gain
Less common

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Convulsions (seizures)
  • headache
  • increased sweating
  • irritability or restlessness
  • muscle cramps
  • nausea or vomiting
  • stomach cramps
  • trembling
  • trouble with sleeping, and vivid dreams

For Healthcare Professionals

Applies to amitriptyline / chlordiazepoxide: oral tablet


The most frequently reported side effects included drowsiness, dry mouth, constipation, and blurred vision.[Ref]


Frequency not reported: Apprehension, confusion, delusions, drug habituation/dependence, dysphoria, euphoria, hallucinations, hypomania, impotence, increased/decreased libido, insomnia, poor concentration, restlessness, vivid dreams, withdrawal symptoms[Ref]

Nervous system

Frequency not reported: Ataxia, convulsions, dizziness, drowsiness, EEG pattern changes, extrapyramidal symptoms, extremity numbness/tingling/paresthesia, headache, incoordination, peculiar taste, stroke, syncope, tremor[Ref]


Frequency not reported: Abdominal cramps, black tongue, bloating, constipation, diarrhea, dry mouth, epigastric distress, nausea, paralytic ileus, parotid swelling, stomatitis, tongue edema, vomiting[Ref]


Frequency not reported: Alopecia, face edema, increased perspiration, photosensitization, pruritus, purpura, skin rash, sweating, urticaria[Ref]


Frequency not reported: Arrhythmias, heart block, hypertension, hypotension, myocardial infarction, palpitations, tachycardia[Ref]


Frequency not reported: Breast enlargement, galactorrhea, minor menstrual abnormalities, testicular swelling, urinary frequency, urinary retention, urinary tract dilation[Ref]


Frequency not reported: Agranulocytosis, bone marrow depression, eosinophilia, granulocytopenia, thrombocytopenia


Frequency not reported: Anorexia, blood sugar level elevation/lowering, weight gain/loss[Ref]


Frequency not reported: Fatigue, lethargy, malaise, weakness[Ref]


Frequency not reported: Accommodation disturbance, blurred vision, mydriasis[Ref]


Frequency not reported: Hepatic dysfunction, jaundice[Ref]


Frequency not reported: Gynecomastia, syndrome of inappropriate antidiuretic hormone (SIADH) secretion[Ref]


Frequency not reported: Muscle cramps[Ref]


Frequency not reported: Nasal congestion[Ref]


1. "Product Information. Amitriptyline-Chlordiazepoxide (amitriptyline-chlordiazepoxide)." Mylan Pharmaceuticals Inc, Morgantown, WV.

Some side effects of Limbitrol DS may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.