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Lemborexant Side Effects

Medically reviewed by Last updated on Dec 27, 2023.

Applies to lemborexant: oral tablet.

Serious side effects of Lemborexant

Along with its needed effects, lemborexant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lemborexant:

More common

Less common


Other side effects of Lemborexant

Some side effects of lemborexant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to lemborexant: oral tablet.


The most commonly reported side effects included somnolence, fatigue, headache, abnormal dreams and/or nightmares.[Ref]

Nervous system

Very common (10% or more): Somnolence (up to 10.5%)

Common (1% to 10%): Headache, sleep paralysis

Frequency not reported: Cataplexy-like symptoms, lethargy[Ref]


Common (1% to 10%): Abnormal dreams, nightmare

Frequency not reported: Complex sleep behavior, hypnagogic hallucinations, suicidal ideation, worsening of depression[Ref]


Common (1% to 10%): Fatigue

Frequency not reported: Sluggishness[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "Australian Product Information."

2. (2020) "Product Information. Dayvigo (lemborexant)." Eisai Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.