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Lemborexant Dosage

Medically reviewed by Drugs.com. Last updated on May 23, 2022.

Applies to the following strengths: 5 mg; 10 mg

Usual Adult Dose for Insomnia

5 mg orally once a day at bedtime

  • Maximum dose: 10 mg once at bedtime

Use: For the treatment of patients with insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild liver dysfunction: No adjustment recommended.
Moderate liver dysfunction: Maximum dose 5 mg/day at bedtime
Severe liver dysfunction: Not recommended.

Dose Adjustments

USE WITH STRONG OR MODERATE CYP450 3A4 INHIBITORS: Not recommended.

USE WITH WEAK CYP450 3A4 INHIBITORS: Up to 5 mg orally once a day immediately prior to bedtime

  • Maximum dose: 5 mg/day

USE WITH STRONG OR MODERATE CYP450 3A4 INDUCERS: Not recommended.

Precautions

CONTRAINDICATIONS: Patients with narcolepsy

Safety and efficacy have not been established in children.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:

  • Take immediately before going to bed.
  • Dose should be taken with at least 7 hours remaining before the planned time of awakening.
  • Time to sleep onset may be delayed if taken with or soon after a meal.

Storage requirements:
  • Store at 20C to 25C.

Patient advice:
  • Read the approved patient labeling.
  • Take only when preparing for or getting into bed and only if you can stay in bed for a full night (at least 7 hours) before being active again.
  • The effect of this drug may be delayed if taken with or soon after a meal.
  • This drug can impair daytime wakefulness even when used as prescribed. The risk of daytime impairment increases if you do not have a full night of sleep.
  • Use caution if you are driving and doing activities requiring complete mental alertness.
  • Increased drowsiness may increase your risk of falling.
  • This drug may cause complex sleep behaviors, including sleepwalking, sleep-driving, preparing and eating food, making phone calls, or having sex while not being fully awake. Discontinue and notify your healthcare provider immediately if you develop any of these symptoms.
  • Report any worsening of depression or suicidal thoughts immediately.
  • There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to this drug. Talk to your doctor if you are pregnant.
  • Do not consume alcohol while taking this drug.
  • Tell your doctor all your medical conditions, and all the other drugs you are taking, with or without a prescription.
  • Do not increase the prescribed dose of this drug and inform your doctor if you think the drug "does not work".

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.