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Ipratropium Inhalation Aerosol Side Effects

Generic name: ipratropium

Medically reviewed by Last updated on Feb 17, 2024.

Note: This document contains side effect information about ipratropium. Some dosage forms listed on this page may not apply to the brand name Ipratropium Inhalation Aerosol.

Applies to ipratropium: inhalation solution.

Serious side effects

Along with its needed effects, ipratropium (the active ingredient contained in Ipratropium Inhalation Aerosol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ipratropium:

More common

Less common


Incidence not known

Other side effects

Some side effects of ipratropium may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common or rare

For Healthcare Professionals

Applies to ipratropium: compounding powder, inhalation aerosol, inhalation solution.


The most common adverse reactions were bronchitis, COPD exacerbation, dyspnea, headache, throat irritation, cough, dry mouth, gastro-intestinal motility disorders (including constipation, diarrhea and vomiting), nausea, and dizziness.[Ref]


Very common (10% or more): Bronchitis (up to 14.6%), upper respiratory tract infection (up to 13.2%)

Common (1% to 10%): Chest pain, cough, dyspnea, bronchospasm, sputum increased, pharyngitis, rhinitis, sinusitis, throat irritation

Uncommon (0.1% to 1%): Paradoxical bronchospasm, laryngospasm, pharyngeal edema, dry throat[Ref]


Common (1% to 10%): Mouth dryness, nausea, gastrointestinal motility disorder, dyspepsia

Uncommon (0.1% to 1%): Constipation, diarrhea, taste perversion, vomiting, stomatitis

Frequency not reported: Mouth edema[Ref]


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Urinary retention[Ref]


Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Arthritis[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Tremor, nervousness[Ref]


Common (1% to 10%): Influenza-like symptoms, pain[Ref]


Uncommon (0.1% to 1%): Hypertension, palpitations, supraventricular tachycardia

Rare (less than 0.1%): Atrial fibrillation, rate increased

Frequency not reported: Hypotension, palpitation, tachycardia[Ref]


Uncommon (0.1% to 1%): Rash, pruritus

Rare (less than 0.1%): Urticaria[Ref]


Uncommon (0.1% to 1%): Hypersensitivity, anaphylactic reactions, angioedema of tongue, lips, face

Frequency not reported: Urticaria (including giant urticaria), laryngospasm[Ref]


Uncommon (0.1% to 1%): Blurred vision, mydriasis, intraocular pressure increased, glaucoma, eye pain, halo vision, conjunctival hyperemia, corneal edema

Rare (less than 0.1%): Accommodation disorder

Frequency not reported: Precipitation or worsening of narrow-angle glaucoma, acute eye pain[Ref]


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10. Levin DC, Little KS, Laughlin KR, Galbraith JM, Gustman PM, Murphy D, Kram JA, Hardie G, Reuter C, Ostransky D, Mcfarland K (1996) "Addition of anticholinergic solution prolongs bronchodilator effect of beta(2) agonists in patients with chronic obstructive pulmonary disease." Am J Med, 100 Suppl, s40-8

11. Lozewicz S (1989) "Bladder outflow obstruction induced by ipratropium bromide." Postgrad Med J, 65, p. 260-1

12. Pras E, Stienlauf S, Pinkhas J, Sidi Y (1991) "Urinary retention associated with ipratropium bromide." DICP, 25, p. 939-40

13. Verheijen-Breemhaar L, Bogaard JM, Hilvering C (1982) "Comparison of the bronchodilatory action and side-effects of ipratropium bromide and thiazinamium methyl sulphate: a long-term, double-blind, crossover trial in patients with chronic bronchitis." Pharmatherapeutica, 3, p. 180-7

14. Braun SR, Levy SF (1991) "Comparison of ipratropium bromide and albuterol in chronic obstructive pulmonary disease: a three-center study." Am J Med, 91, s28-32

15. O'Driscoll BR (1989) "Supraventricular tachycardia caused by nebulised ipratropium bromide." Thorax, 44, p. 312

16. Cabana MD, Johnson H, Lee CKK, Helfaer M (1998) "Transient anisocoria secondary to nebulized ipratropium bromide." Clin Pediat, 37, p. 445-7

17. Kizer KM, Bess DT, Bedford NK (1999) "Blurred vision from ipratropium bromide." Am J Health Syst Pharm, 56, p. 914

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.