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Intermezzo Side Effects

Generic name: zolpidem

Medically reviewed by Last updated on May 23, 2024.

Note: This document contains side effect information about zolpidem. Some dosage forms listed on this page may not apply to the brand name Intermezzo.

Applies to zolpidem: oral capsule, oral tablet, oral tablet extended release. Other dosage forms:


Oral route (Capsule; Tablet; Tablet, Extended Release; Spray)

Warning: Complex Sleep BehaviorsComplex sleep behaviors including sleep-walking, sleep-driving, and engaging in other activities while not fully awake may occur following use of zolpidem tartrate. Some of these events may result in serious injuries, including death. Discontinue zolpidem tartrate immediately if a patient experiences a complex sleep behavior.

Serious side effects of Intermezzo

Along with its needed effects, zolpidem (the active ingredient contained in Intermezzo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking zolpidem:

Less common


Get emergency help immediately if any of the following symptoms of overdose occur while taking zolpidem:

Symptoms of overdose

Other side effects of Intermezzo

Some side effects of zolpidem may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to zolpidem: oral capsule, oral spray, oral tablet, oral tablet extended release, sublingual tablet.


The most commonly reported side effects included dizziness, headache, and somnolence.[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 23.5%), headache (up to 19%), somnolence (up to 15%)

Common (1% to 10%): Amnesia, amnestic effects, anterograde amnesia, ataxia, attention disturbance, balance disorder, burning sensation, cognitive disorders, daytime drowsiness, drowsiness, drugged feelings, hypoesthesia, involuntary muscle contractions, lethargy, lightheadedness, memory disorders, memory impairment, paresthesia, postural dizziness, tremor, vertigo

Uncommon (0.1% to 1%): Cerebrovascular disorder, decreased cognition, difficulty concentrating, dysarthria, migraine, sleeping (with daytime dosing), speech disorder, stupor, syncope, taste perversion

Rare (less than 0.1%): Abnormal gait, dementia, depressed level of consciousness, gait disturbance, hypokinesia, hypotonia, neuralgia, neuritis, neuropathy, paresis, parosmia, restless legs, sciatica

Frequency not reported: Central nervous system (CNS)-depressant effects, impaired concentration, next-day impairment, next day somnolence

Postmarketing reports: Dysgeusia, memory disturbances, reduced alertness[Ref]


Common (1% to 10%): Abnormal dreams, agitation, anxiety, apathy, binge eating, confusion, depersonalization, depressed mood, depression, disinhibition, disorientation, euphoria, euphoric mood, exacerbated insomnia, hallucinations, inappropriate behavior, insomnia, major depression, mood swings, nervousness, nightmare, psychomotor retardation, restlessness, sleep disorder, stress symptoms

Uncommon (0.1% to 1%): Aggression, confusional state, detached, emotional lability, hypnagogic hallucinations, illusion, irritability, somnambulism, visual hallucinations

Rare (0.01% to 0.1%): Abnormal thinking, aggressive reaction, attempted suicide, decreased libido, delusion, hysteria, libido disorder, manic reaction, neurosis, panic attacks, personality disorder

Very rare (less than 0.01%): Dependence, withdrawal effects/symptoms

Frequency not reported: Abnormal behavior, abnormal thinking, aggravated depression, anger, behavior changes, complex behaviors, continuing depression, hallucinations not otherwise specified (NOS), psychosis

Postmarketing reports: Aggravated insomnia, other adverse behavioral effects, perceptual disturbances, rages[Ref]


Common (1% to 10%): Abdominal discomfort, abdominal pain, abdominal pain upper, abdominal tenderness, constipation, diarrhea, dry mouth, dyspepsia, flatulence, gastroenteritis, frequent bowel movements, gastroesophageal reflux disease, nausea, vomiting

Uncommon (0.1% to 1%): Dysphagia

Rare (less than 0.1%): Altered saliva, enteritis, eructation, esophagospasm, gastritis, hemorrhoids, increased saliva, tenesmus, intestinal obstruction, rectal hemorrhage, tooth caries[Ref]


Common (1% to 10%): Asthenia, chest discomfort, contusion, exposure to poisonous plant, fatigue, increased body temperature, labyrinthitis, neck injury, otitis externa, pyrexia, tinnitus

Uncommon (0.1% to 1%): Fall/falling, fever, malaise, trauma

Rare (0.01% to 0.1%): Feeling strange, face edema, increased tolerance, intoxicated feeling, otitis media, pain, rigors

Very rare (less than 0.01%): Rebound effect

Frequency not reported: Drug tolerance

Postmarketing reports: Drunk feeling[Ref]


Common (1% to 10%): Hiccup, lower respiratory infection, lower respiratory tract infection, nasopharyngitis, pharyngitis, rhinitis, sinusitis, throat irritation, upper respiratory infection, upper respiratory tract infection

Uncommon (0.1% to 1%): Bronchitis, coughing, dyspnea

Rare (less than 0.1%): Bronchospasm, epistaxis, hypoxia, laryngitis, pneumonia, pulmonary edema, pulmonary embolism, respiratory depression, yawning

Postmarketing reports: Cough, dry throat[Ref]


Common (1% to 10%): Abnormal vision, altered visual depth perception, asthenopia, blurred vision, diplopia, eye redness, visual disturbance

Uncommon (0.1% to 1%): Eye irritation, eye pain, scleritis

Rare (0.01% to 0.1%): Abnormal accommodation, abnormal lacrimation, conjunctivitis, corneal ulceration, glaucoma, periorbital edema, photopsia

Very rare (less than 0.01%): Visual impairment[Ref]


Common (1% to 10%): Arthralgia, back pain, muscle cramp, myalgia, neck pain

Uncommon (0.1% to 1%): Arthritis, leg cramps, muscle spasms, muscle/muscular weakness

Rare (less than 0.1%): Arthrosis, tendinitis[Ref]


Common (1% to 10%): Dysuria, menorrhagia, urinary tract infection, vulvovaginal dryness

Uncommon (0.1% to 1%): Cystitis, menstrual disorder, urinary incontinence, vaginitis

Rare (less than 0.1%): Breast pain, impotence, micturition frequency, nocturia, polyuria, urinary retention

Postmarketing reports: Dysmenorrhea[Ref]


Common (1% to 10%): Rash, skin wrinkling, urticaria

Uncommon (0.1% to 1%): Hyperhidrosis, increased sweating, pruritus

Rare (less than 0.1%): Acne, bullous eruption, dermatitis, furunculosis, photosensitivity reaction, purpura

Frequency not reported: Angioneurotic edema

Postmarketing reports: Contact dermatitis[Ref]


Common (1% to 10%): Infection, influenza, influenza-like symptoms

Rare (less than 0.1%): Abscess, herpes simplex, herpes zoster[Ref]


Common (1% to 10%): Increased blood pressure, palpitations

Uncommon (0.1% to 1%): Chest pain, edema, hypertension, pallor, postural hypotension, tachycardia

Rare (less than 0.1%): Aggravated hypertension, angina pectoris, arrhythmia, arteritis, circulatory failure, extrasystoles, flushing, hot flashes, hypotension, myocardial infarction, phlebitis, thrombosis, varicose veins, ventricular tachycardia

Postmarketing reports: Increased heart rate[Ref]


Common (1% to 10%): Anorexia, appetite disorder

Uncommon (0.1% to 1%): Hyperglycemia, thirst

Rare (less than 0.1%): Decreased weight, gout, hypercholesteremia, hyperlipidemia, increased appetite, tetany[Ref]


Common (1% to 10%): Allergy

Rare (less than 0.1%): Aggravated allergy, allergic reaction, anaphylactic shock

Frequency not reported: Angioedema, anaphylaxis, serious anaphylactic reactions, serious anaphylactoid reactions[Ref]


Uncommon (0.1% to 1%): Abnormal hepatic function, elevated liver enzymes, increased ALT

Rare (less than 0.1%): Bilirubinemia, cholestatic liver injury, hepatocellular liver injury, increased alkaline phosphatase, increased AST, mixed liver injury

Postmarketing reports: Acute hepatocellular, cholestatic, or mixed liver injury with or without jaundice[Ref]


Rare (less than 0.1%): Anemia, hyperhemoglobinemia, increased erythrocyte sedimentation rate (ESR), leukopenia, lymphadenopathy, macrocytic anemia[Ref]


Rare (less than 0.1%): Acute renal failure, renal pain[Ref]


Rare (less than 0.1%): Breast fibroadenosis, breast neoplasm[Ref]


Rare (less than 0.1%): Injection-site inflammation

Frequency not reported: Transient paresthesia of the tongue, transient sublingual erythema[Ref]

Tongue paresthesia and sublingual erythema occurred in patients given sublingual tablet formulations.[Ref]

Frequently asked questions


1. (2001) "Product Information. Ambien (zolpidem)." sanofi-aventis

2. (2005) "Product Information. Ambien CR (zolpidem)." Sanofi-Synthelabo Inc

3. Cerner Multum, Inc. "UK Summary of Product Characteristics."

4. Cerner Multum, Inc. "Australian Product Information."

5. (2009) "Product Information. Edluar (zolpidem)." Meda Pharmaceuticals

6. (2011) "Product Information. Intermezzo (zolpidem)." Purdue Pharma LP

7. (2017) "Product Information. Zolpimist (zolpidem)." Magna Pharmaceuticals Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.