Ingrezza Side Effects

Generic name: valbenazine

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 15, 2025.

Note: This document provides detailed information about Ingrezza Side Effects associated with valbenazine. Some dosage forms listed on this page may not apply specifically to the brand name Ingrezza.

Applies to valbenazine: oral capsule.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Do not take this medicine if you are also taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan®), phenelzine (Nardil®), selegiline (Eldepryl®), or tranylcypromine (Parnate®) within 14 days of each other. If you have questions, check with your doctor.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed, especially if they have a condition called Huntington's disease. If you or your caregiver notice any of these side effects, tell your doctor right away.

This medicine may cause serious allergic reaction, including angioedema, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs.

This medicine may cause some people to become sleepy or drowsy. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem, including QT prolongation.

Check with your doctor right away if you have difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, seizures, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause parkinsonism (a movement disorder). Check with your doctor right away if you have difficulty swallowing, loss of balance control, mask-like face, shuffling walk, slowed movements, slurred speech, stiffness of the arms and legs, tic-like or jerky movements of the head, face, mouth, and neck, or trembling and shaking of the fingers and hands.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Ingrezza

Some side effects of valbenazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Ingrezza

Along with its needed effects, valbenazine (the active ingredient contained in Ingrezza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking valbenazine:

See also:

For healthcare professionals

Applies to valbenazine: oral capsule.

General adverse events

The most common adverse reaction (5% or more and twice the rate of placebo) was somnolence.

A total of 3% of patients discontinued treatment because of adverse reactions.^[Ref]

Nervous system

• Very common (10% or more): Somnolence/fatigue/sedation (10.9%)
• Common (1% to 10%): Anticholinergic effects (dry mouth, constipation, attention disturbance, blurred vision, urinary retention), balance disorders/fall/gait disturbance/dizziness, headache, akathisia/restlessness, drooling, dyskinesia,

non-akathisia extrapyramidal symptoms^[Ref]

Gastrointestinal

• Common (1% to 10%): Vomiting, nausea^[Ref]

Hepatic

• Common (1% to 10%): Increased alkaline phosphatase and bilirubin^[Ref]

Metabolic

• Common (1% to 10%): Increased blood glucose, increased weight, increased prolactin^[Ref]

Musculoskeletal

• Common (1% to 10%): Arthralgia^[Ref]

Psychiatric

• Common (1% to 10%): Anxiety, insomnia^[Ref]

Respiratory

• Common (1% to 10%): Respiratory infections^[Ref]

Frequently asked questions

• How much does Ingrezza cost and will insurance cover it?
• Which pharmacies can dispense Ingrezza?
• How long does it take for Ingrezza to work?
• Does Ingrezza cause weight gain?
• Ingrezza mechanism of action: How does it work?
• What condition is Ingrezza used to treat?
• Can Ingrezza capsules be opened?
• How effective is Ingrezza?
• Austedo vs Ingrezza: How do they compare?

Further information

Ingrezza side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer