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Ingrezza: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on May 15, 2024.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Ingrezza may be used to treat adults with tardive dyskinesia or chorea associated with Huntington's disease. It works by blocking VMAT2, which reduces the uptake of dopamine by the brain. Although some reduction in symptoms may be noticed within a week or two, it can take up to 32 weeks (for TD) or up to 12 weeks (for chorea associated with HD) to have an effect. Side effects include fatigue, sleepiness, changes in balance, a rash, and a dry mouth.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Ingrezza may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Ingrezza. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Ingrezza interacts with over 455 drugs and most of these interactions are considered moderate or major. Common medications that may interact with Ingrezza include:

Grapefruit juice and grapefruit products may increase the blood levels of Ingrezza and increase side effects such as drowsiness and QT prolongation.

Alcohol may worsen the side effects of Ingrezza such as drowsiness and dizziness.

Note that this list is not all-inclusive and includes only common medications that may interact with Ingrezza. You should refer to the prescribing information for Ingrezza for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Ingrezza only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: May 14, 2024.