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Imiglucerase Side Effects

For the Consumer

Applies to imiglucerase: intravenous powder for solution

Along with its needed effects, imiglucerase may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of imiglucerase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal discomfort
  • decrease in blood pressure, decrease in frequency of urination
  • dizziness
  • headache
  • itching
  • nausea
  • rash

For Healthcare Professionals

Applies to imiglucerase: intravenous powder for injection

General

Experience in patients treated with this drug have revealed that about 13.8% of patients experienced adverse events which were judged to be related to administration and included discomfort, pruritus, burning, swelling, or sterile abscess at the site of venipuncture.[Ref]

Local

Common (1% to 10%): Discomfort, burning, swelling, sterile abscess
Frequency not reported: Pruritus[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, abdominal pain, vomiting, diarrhea
Uncommon (0.1% to 1%): Abdominal cramping[Ref]

Cardiovascular

Common (1% to 10%): Tachycardia
Uncommon (0.1% to 1%): Flushing, hypotension, cyanosis[Ref]

Immunologic

Common (1% to 10%): Hypersensitivity reaction
Rare (less than 0.1%): Anaphylactoid reaction[Ref]

Dermatologic

Common (1% to 10%): Rash, urticaria, pruritus, angioedema[Ref]

Musculoskeletal

Common (1% to 10%): Backache
Uncommon (0.1% to 1%): Arthralgia[Ref]

Respiratory

Common (1% to 10%): Dyspnea, coughing[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness
Uncommon (0.1% to 1%): Paresthesia[Ref]

Other

Common (1% to 10%): Fatigue, fever, chills
Uncommon (0.1% to 1%): Rigors
Frequency not reported: Chest discomfort, peripheral edema[Ref]

References

1. "Product Information. Cerezyme (imiglucerase)." Genzyme Corporation, Cambridge, MA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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