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Iluvien Side Effects

Generic Name: fluocinolone ophthalmic

Note: This page contains information about the side effects of fluocinolone ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Iluvien.

For the Consumer

Applies to fluocinolone ophthalmic: intraocular implant

In addition to its needed effects, some unwanted effects may be caused by fluocinolone ophthalmic (the active ingredient contained in Iluvien). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking fluocinolone ophthalmic, check with your doctor or nurse immediately:

More common:
  • Blindness
  • bloody eye
  • blurred vision
  • burning, dry, or itching eyes
  • change in color vision
  • decreased vision
  • difficulty seeing at night
  • discharge or excessive tearing
  • increased sensitivity of the eyes to sunlight
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision

Minor Side Effects

Some of the side effects that can occur with fluocinolone ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:
  • Feeling of having something in the eye

For Healthcare Professionals

Applies to fluocinolone ophthalmic: intravitreal implant


The most frequently reported side effects were cataract operation, cataract, and increased intraocular pressure.[Ref]


Very common (10% or more): Cataract (82%), cataract operation (up to 80%), increased intraocular pressure (up to 34%), myodesopsia (21%), eye pain (15%), conjunctival hemorrhage (13%)
Common (1% to 10%): Glaucoma, vitreous hemorrhage, conjunctival hemorrhage, blurred vision, reduced visual acuity, vitreous floaters, trabeculectomy, vitrectomy, trabeculoplasty, eye irritation, conjunctivitis, corneal edema, foreign body sensation in eyes, ocular hyperemia, ocular discomfort, photophobia, anterior chamber cell, blepharitis, choroidal detachment, diplopia, hyphema
Uncommon (0.1% to 1%): Endophthalmitis, retinal vascular occlusion, optic nerve disorder, maculopathy, optic atrophy, conjunctival ulcer, iris neovascularization, retinal exudates, vitreous degeneration, vitreous detachment, posterior capsule opacification, iris adhesion, sclera thinning, eye discharge, eye pruritus, removal of extruded implant from sclera[Ref]


Uncommon (0.1% to 1%): Extrusion of implant, implant in line of sight, procedural complication, procedural pain, device dislocation[Ref]


Common (1% to 10%): Pneumonia, nasopharyngitis, sinusitis, upper respiratory tract infection, influenza, cough[Ref]


Common (1% to 10%): Arthralgia, back pain, limb pain[Ref]

Nervous system

Very common (10% or more): Headache (33%)
Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Vomiting, nausea[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Anemia (11%)[Ref]


Common (1% to 10%): Renal failure[Ref]


1. "Product Information. Retisert (fluocinolone ophthalmic)." Bausch and Lomb, Rochester, NY.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Iluvien may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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