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Iluvien Side Effects

Generic Name: fluocinolone ophthalmic

Note: This document contains side effect information about fluocinolone ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Iluvien.

For the Consumer

Applies to fluocinolone ophthalmic: intraocular implant

Along with its needed effects, fluocinolone ophthalmic (the active ingredient contained in Iluvien) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fluocinolone ophthalmic:

More common
  • Blindness
  • bloody eye
  • blurred vision
  • burning, dry, or itching eyes
  • change in color vision
  • decreased vision
  • difficulty seeing at night
  • discharge or excessive tearing
  • increased sensitivity of the eyes to sunlight
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision

Some side effects of fluocinolone ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Feeling of having something in the eye

For Healthcare Professionals

Applies to fluocinolone ophthalmic: intravitreal implant


The most frequently reported side effects were cataract operation, cataract, and increased intraocular pressure.[Ref]


Very common (10% or more): Cataract (82%), cataract operation (up to 80%), increased intraocular pressure (up to 34%), myodesopsia (21%), eye pain (15%), conjunctival hemorrhage (13%)
Common (1% to 10%): Glaucoma, vitreous hemorrhage, conjunctival hemorrhage, blurred vision, reduced visual acuity, vitreous floaters, trabeculectomy, vitrectomy, trabeculoplasty, eye irritation, conjunctivitis, corneal edema, foreign body sensation in eyes, ocular hyperemia, ocular discomfort, photophobia, anterior chamber cell, blepharitis, choroidal detachment, diplopia, hyphema
Uncommon (0.1% to 1%): Endophthalmitis, retinal vascular occlusion, optic nerve disorder, maculopathy, optic atrophy, conjunctival ulcer, iris neovascularization, retinal exudates, vitreous degeneration, vitreous detachment, posterior capsule opacification, iris adhesion, sclera thinning, eye discharge, eye pruritus, removal of extruded implant from sclera[Ref]


Uncommon (0.1% to 1%): Extrusion of implant, implant in line of sight, procedural complication, procedural pain, device dislocation[Ref]


Common (1% to 10%): Pneumonia, nasopharyngitis, sinusitis, upper respiratory tract infection, influenza, cough[Ref]


Common (1% to 10%): Arthralgia, back pain, limb pain[Ref]

Nervous system

Very common (10% or more): Headache (33%)
Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Vomiting, nausea[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Anemia (11%)[Ref]


Common (1% to 10%): Renal failure[Ref]


1. "Product Information. Retisert (fluocinolone ophthalmic)." Bausch and Lomb, Rochester, NY.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Iluvien may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.