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Humalog Junior KwikPen Side Effects

Generic Name: insulin lispro

Note: This document contains side effect information about insulin lispro. Some of the dosage forms listed on this page may not apply to the brand name Humalog Junior KwikPen.

For the Consumer

Applies to insulin lispro: suspension

Along with its needed effects, insulin lispro (the active ingredient contained in Humalog Junior KwikPen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking insulin lispro:

More common
  • Anxious or nervous feeling
  • behavior change similar to being drunk
  • blurred vision
  • cold sweats
  • confusion or difficulty thinking
  • depression
  • dizziness or lightheadedness
  • drowsiness
  • excessive hunger
  • fast heartbeat
  • fever or chills
  • headache
  • irritability or abnormal behavior
  • lower back or side pain
  • nightmares
  • painful or difficult urination
  • restless sleep
  • seizures
  • shakiness
  • slurred speech
  • tingling in the hands, feet, lips, or tongue
Less common
  • Dry, red, hot, or irritated skin
Less common or rare
  • Depression of the skin at the injection site
  • dryness of the mouth
  • fast or weak pulse
  • itching, redness, or swelling at the injection site
  • muscle cramps or pain
  • nausea or vomiting
  • skin rash or itching over the whole body
  • sweating
  • thickening of the skin at the injection site
  • trouble breathing
  • unusual tiredness or weakness
Incidence not known
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased urine
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • hives or itching skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redistribution or accumulation of body fat
  • tightness in the chest
  • unusual weight gain or loss

Some side effects of insulin lispro may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Body aches or pain
  • congestion
  • runny nose
  • sneezing
  • stuffy nose
  • tender, swollen glands in the neck
  • voice changes
Incidence not known
  • Redness, swelling, or itching at the injection site

For Healthcare Professionals

Applies to insulin lispro: injectable solution, subcutaneous solution


Adverse reactions observed have included hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, and pruritus.[Ref]


Weight gain has been reported with insulin therapy and has been attributed to the anabolic effects of insulin and the decrease in glucosuria.[Ref]

Very common (10% or more): Hypoglycemia
Frequency not reported: Weight gain[Ref]


Frequency not reported: Allergic reactions including anaphylaxis[Ref]

Hypersensitivity side effects have included both local and systemic reactions. Anaphylaxis has been reported. Local reactions have presented as erythema, local edema, and pruritus at the injection site. Most minor reactions to insulin at the injection site resolve in a few days to a few weeks.

Generalized allergy to insulin may present as a whole body rash, dyspnea, wheezing, hypotension, tachycardia, or diaphoresis. In clinical trials, pruritus (with or without rash) was seen in 17 patients receiving human insulin (n=2969) and 30 patients receiving insulin lispro (n=2944).[Ref]


Common (1% to 10%): Infusion site reactions
Rare (less than 0.1%): Catheter occlusions/month[Ref]


Rapid improvement in glucose control has been associated with a transitory, reversible ophthalmologic refraction disorder and worsening of diabetic retinopathy. However, long-term glycemic control decreases the risk of diabetic retinopathy.[Ref]

Uncommon (0.1% to 1%): Refraction disorder, worsening of diabetic retinopathy[Ref]

Nervous system

Very common (10% or more): Headache (up to 29.6%)
Rare (less than 0.1%): Painful peripheral neuropathy[Ref]

Rapid improvement in glucose control has been associated with a transitory, reversible acute painful peripheral neuropathy. However, long-term glycemic control decreases the risk.[Ref]


The clinical significance of the development of these antibody titers is unknown.[Ref]

Very common (10% or more): Flu syndrome (up to 34.6%), infection (up to 13.6%)
Frequency not reported: Anti-insulin antibody titers[Ref]


Frequency not reported: Peripheral edema[Ref]

Insulin may cause sodium retention and edema, especially as metabolic control is improving.[Ref]


Long-term use of insulin may cause lipodystrophy at the site of repeated injection. Lipodystrophy includes lipohypertrophy, a thickening of adipose tissue, and lipoatrophy, thinning of adipose tissue.[Ref]

Uncommon (0.1% to 1%): Urticaria, rash
Frequency not reported: Lipodystrophy including lipohypertrophy and lipoatrophy[Ref]


Common (1% to 10%): Nausea, diarrhea, abdominal pain[Ref]


Common (1% to 10%): Urinary tract infection, dysmenorrhea[Ref]


Common (1% to 10%): Myalgia[Ref]


Very common (10% or more): Pain (up to 19.8%)
Common (1% to 10%): Fever[Ref]


Very common (10% or more): Pharyngitis (up to 33.3%), rhinitis (up to 24.7%), increased cough (up to 17.3%)
Common (1% to 10%): Sinusitis, bronchitis[Ref]


1. "Product Information. Humalog (insulin lispro)." Lilly, Eli and Company, Indianapolis, IN.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Humalog Junior KwikPen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

More about Humalog Junior KwikPen (insulin lispro)

Consumer resources

Other brands: Humalog, Humalog KwikPen

Professional resources

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