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Glucotrol XL Side Effects

Generic Name: glipizide

Note: This document contains side effect information about glipizide. Some of the dosage forms listed on this page may not apply to the brand name Glucotrol XL.

For the Consumer

Applies to glipizide: oral tablet, oral tablet extended release

Along with its needed effects, glipizide (the active ingredient contained in Glucotrol XL) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glipizide:

Less Common

  • Anxiety
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • difficulty with moving
  • dizziness
  • fainting
  • fast heartbeat
  • headache
  • increased hunger
  • joint pain
  • leg cramps
  • muscle aching or cramping
  • muscle pain or stiffness
  • nausea
  • nervousness
  • nightmares
  • pain in the joints
  • problems in urination or increase in the amount of urine
  • seizures
  • shakiness
  • slurred speech
  • sweating
  • swollen joints
  • unusual tiredness or weakness


  • Abdominal or stomach pain
  • bloating
  • bloody or black, tarry stools
  • body aches or pain
  • burning, dry, or itching eyes
  • clay-colored stools
  • congestion
  • constipation
  • cough
  • dark urine
  • decreased vision or other changes in vision
  • diarrhea
  • difficult or labored breathing
  • difficult or painful urination
  • dryness or soreness of the throat
  • excessive tearing
  • fainting
  • fast, slow, or irregular heartbeat
  • feeling of warmth
  • fever
  • heartburn
  • hoarseness
  • indigestion
  • itching
  • loss of appetite
  • pain in the eye
  • pounding in the ears
  • rash
  • redness of the face, neck, arms and occasionally, upper chest
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • severe stomach pain
  • shortness of breath
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble in swallowing
  • unpleasant breath odor
  • voice changes
  • vomiting of blood or material that looks like coffee grounds
  • wheezing
  • yellow eyes or skin

Incidence Not Known

  • Agitation
  • back or leg pains
  • bleeding gums
  • blood in the urine or stools
  • chest pain
  • convulsions
  • decreased urine output
  • fluid-filled skin blisters
  • general body swelling
  • general feeling of tiredness or weakness
  • high fever
  • hostility
  • increased thirst
  • irritability
  • lethargy
  • light-colored stools
  • lower back or side pain
  • muscle twitching
  • nosebleeds
  • pinpoint red pots on the skin
  • rapid weight gain
  • sensitivity to the sun
  • skin thinness
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of the face, ankles, or hands
  • unusual bleeding or bruising

Some side effects of glipizide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Indigestion
  • passing of gas

Less Common

  • Acid or sour stomach
  • belching
  • excess air or gas in the stomach or intestines
  • full feeling
  • pain
  • sleeplessness
  • sneezing
  • stuffy nose
  • trouble sleeping
  • unable to sleep


  • Decreased interest in sexual intercourse
  • dizziness or lightheadedness
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • flushing or redness of the skin
  • headache, severe and throbbing
  • hives or welts
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • mood or mental changes
  • muscle stiffness
  • muscle tension or tightness
  • sensation of spinning
  • skin rash, encrusted, scaly, and oozing
  • sleepiness or unusual drowsiness
  • unusually warm skin
  • walking in unusual manner
  • weight loss

Incidence Not Known

  • Increased sensitivity of the skin to sunlight
  • severe sunburn

For Healthcare Professionals

Applies to glipizide: compounding powder, oral tablet, oral tablet extended release


The majority of side effects have been dose related, transient, and have responded to dose reduction or withdrawal of the drug. As with other sulfonylureas, some side effects associated with hypersensitivity may be severe and deaths have been reported in some instances.[Ref]


Common (1% to 10%): Syncope

Uncommon (less than 1%): Arrhythmia, flushing, hypertension[Ref]


Common (1% to 10%): Sweating, pruritus

Uncommon (less than 1%): Rash, urticaria

Frequency not reported: Rash, erythema, morbilliform or maculopapular eruptions, urticaria, pruritus, eczema[Ref]

Dermatologic side effects frequently disappear with continued therapy. Photosensitivity has been reported with other sulfonylureas.[Ref]


Gastrointestinal side effects appear to be dose-related and may disappear on division or reduction of dosage.[Ref]

Common (1% to 10%): Nausea, diarrhea, constipation, gastralgia, vomiting, flatulence, dyspepsia

Uncommon (less than 1%): Anorexia, trace blood in stool

Frequency not reported: Gastrointestinal irritation, gastrointestinal bleeding

Postmarketing reports: Abdominal pain[Ref]


Common (1% to 10%): Polyuria

Uncommon (less than 1%): Dysuria[Ref]


Common (1% to 10%): Hypoglycemia

Uncommon (less than 1%): Thirst

Frequency not reported: Disulfiram like reactions, hepatic porphyria, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), elevation of LDH[Ref]


Common (1% to 10%): Arthralgia, leg cramps, myalgia[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, nervousness, tremors, paresthesia, hypesthesia

Uncommon (less than 1%): Migraine

Frequency not reported: Drowsiness[Ref]


Common (1% to 10%): Blurred vision

Uncommon (less than 1%): Pain in the eye, conjunctivitis, retinal hemorrhage

Frequency not reported: Diplopia, abnormal vision, visual impairment, decreased vision[Ref]


Common (1% to 10%): Asthenia, pain

Uncommon (less than 1%): Chills, edema

Frequency not reported: Vertigo, malaise[Ref]


Common (1% to 10%): Insomnia, anxiety, depression

Frequency not reported: Confusion[Ref]


Common (1% to 10%): Rhinitis

Uncommon (less than 1%): Pharyngitis, dyspnea[Ref]


Frequency not reported: Leucopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, pancytopenia, elevation of alkaline phosphatase, BUN, and creatinine[Ref]


Frequency not reported: Impaired hepatic function, hepatitis, jaundice, elevation of SGOT

Postmarketing reports: Cholestatic and hepatocellular forms of liver injury accompanied by jaundice[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Glucotrol (glipizide)." Pfizer US Pharmaceuticals, New York, NY.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

4. Prendergast BD "Glyburide and glipizide, second-generation oral sulfonylurea hypoglycemic agents." Clin Pharm 3 (1984): 473-85

5. Brogden RN, Heel RC, Pakes GE, Speight TM, Avery GS "Glipizide: a review of its pharmacological properties and therapeutic use." Drugs 18 (1979): 329-53

6. Lebovitz HE "Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacology, pharmacokinetics and clinical use." Pharmacotherapy 5 (1985): 63-77

7. Moder KG, Schwenk NM "A coproporphyria-like syndrome induced by glipizide." Mayo Clin Proc 66 (1991): 312-6

8. Feinglos MN, Lebovitz HE "Long-term safety and efficacy of glipizide." Am J Med 75 (1983): 60-6

9. Asplund K, Wiholm BE, Lundman B "Severe hypoglycaemia during treatment with glipizide." Diabet Med 8 (1991): 726-31

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.