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Four-Way Nasal Spray Side Effects

Generic Name: oxymetazoline nasal

Note: This document contains side effect information about oxymetazoline nasal. Some of the dosage forms listed on this page may not apply to the brand name Four-Way Nasal Spray.

For the Consumer

Applies to oxymetazoline nasal: nasal solution, nasal spray

Along with its needed effects, oxymetazoline nasal (the active ingredient contained in Four-Way Nasal Spray) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline nasal:

  • Blurred vision
  • fast, irregular, or pounding heartbeat
  • headache, dizziness, drowsiness, or lightheadedness
  • high blood pressure
  • increase in runny or stuffy nose
  • nervousness
  • trembling
  • trouble in sleeping
  • weakness

Some side effects of oxymetazoline nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Burning, dryness, or stinging inside of nose
  • sneezing

For Healthcare Professionals

Applies to oxymetazoline nasal: nasal solution, nasal spray

Cardiovascular

Very rare (less than 0.01%): Tachycardia, palpitations, increased blood pressure[Ref]

Gastrointestinal

Very rare (less than 0.01%): Nausea[Ref]

General

The most commonly reported side effects were discomfort or irritation in the nose, mouth or throat, and sneezing.[Ref]

Nervous system

Very rare (less than 0.01%): Insomnia, nervousness, tremor, anxiety, restlessness, irritability, headache[Ref]

Ocular

Rare (less than 0.1%): Eye irritation, dryness, discomfort/redness[Ref]

Respiratory

Rare (less than 0.1%): Discomfort or irritation in the nose, mouth or throat, sneezing
Frequency not reported: Rhinitis medicamentosa (after prolonged or heavy use)[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Afrin (oxymetazoline nasal)" Schering-Plough, Liberty Corner, NJ.

Some side effects of Four-Way Nasal Spray may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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