Skip to main content

Neo-Synephrine 12 Hour

Generic name: oxymetazoline nasalox-ee-me-TAZ-oh-leen-NAY-sal ]
Brand names: 12 Hour Nasal, 12 Hour Nasal Decongestant, Afrin, Afrin All Night NoDrip, Afrin Allergy Sinus, ... show all 34 brands
Drug class: Nasal antihistamines and decongestants

Medically reviewed by Drugs.com on Dec 21, 2023. Written by Cerner Multum.

What is Neo-Synephrine 12 Hour?

Oxymetazoline is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Neo-Synephrine 12 Hour (for the nose) is for temporary relief of nasal congestion (stuffy nose) caused by allergies or the common cold.

Neo-Synephrine 12 Hour may also be used for purposes not listed in this medication guide.

Neo-Synephrine 12 Hour side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Neo-Synephrine 12 Hour may cause serious side effects. Stop using Neo-Synephrine 12 Hour and call your doctor at once if you have:

Common side effects of Neo-Synephrine 12 Hour may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

Neo-Synephrine 12 Hour (for the nose) is used for temporary relief of nasal congestion caused by allergies or the common cold.

Stop using Neo-Synephrine 12 Hour and call your doctor at once if you have ongoing or worsening symptoms, or if you have severe burning or stinging in your nose after using the nasal spray

Before taking this medicine

You should not use Neo-Synephrine 12 Hour if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

FDA pregnancy category C. It is not known whether Neo-Synephrine 12 Hour will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether oxymetazoline nasal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Neo-Synephrine 12 Hour?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Using the medication too long or too often may worsen your symptoms or cause nasal congestion to clear up and come back.

Call your doctor if your symptoms do not improve after 3 days of treatment.

Do not share this medication with another person, even if they have the same symptoms you have. Sharing a nasal spray bottle can spread infection.

To use the nose drops (nasal solution):

To use the nasal spray:

Do not use the nasal spray more than 2 times in 24 hours.

Wipe the tip of the spray bottle with a clean tissue but do not wash with water or soap.

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

epinephrine topical, pseudoephedrine, sodium chloride nasal, phenylephrine nasal, Afrin

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Keep Neo-Synephrine 12 Hour out of the reach of children. Certain nasal medications can cause serious medical problems in a young child who accidentally sucks on or swallows medicine from the nasal spray bottle.

What should I avoid while using Neo-Synephrine 12 Hour?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect Neo-Synephrine 12 Hour?

Ask a doctor or pharmacist if it is safe for you to use Neo-Synephrine 12 Hour if you are also using any of the following drugs:

This list is not complete and other drugs may interact with Neo-Synephrine 12 Hour. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Does Neo-Synephrine 12 Hour interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Popular FAQ

Does Mucinex help with Covid?

Mucinex products do not help to prevent or treat the COVID-19 virus itself, but might help relieve some of the symptoms of COVID, like chest congestion, cough, or headache. Select a product that targets only the symptoms you have. Continue reading

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.