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Fosaprepitant Side Effects

For the Consumer

Applies to fosaprepitant: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by fosaprepitant. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking fosaprepitant, check with your doctor or nurse immediately:

More common:
  • Black, tarry stools
  • blurred vision
  • chills
  • confusion
  • cough
  • decreased urination
  • difficult or labored breathing
  • dizziness
  • dry mouth
  • fainting
  • fever
  • increase in heart rate
  • lightheadedness
  • lower back or side pain
  • nervousness
  • pain, swelling, or redness at the injection site
  • painful or difficult urination
  • pale skin
  • pounding in the ears
  • rapid breathing
  • slow or fast heartbeat
  • sore throat
  • sunken eyes
  • tenderness, swelling, warmth, or skin discoloration at the injection site
  • thirst
  • tightness in the chest
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wrinkled skin
Less common:
  • Hard lump at the injection site
Rare
  • Blood in the urine
  • changes in patterns and rhythms of speech
  • changes in skin color
  • chest pain or discomfort
  • coma
  • convulsions
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • general feeling of discomfort or illness
  • headache
  • increased sweating
  • increased thirst
  • lightheadedness, dizziness, or fainting
  • muscle pain or cramps
  • nausea or vomiting
  • pain, tenderness, or swelling of the foot or leg
  • slurred speech
  • swelling
  • swelling of the face, ankles, or hands
  • trouble with speaking
  • troubled breathing with exertion
Incidence not known:
  • Difficulty with swallowing
  • hives or welts, itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin

Minor Side Effects

Some of the side effects that can occur with fosaprepitant may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • continuing ringing or buzzing or other unexplained noise in ears
  • diarrhea
  • difficulty having a bowel movement (stool)
  • dizziness
  • feeling of indigestion
  • hair loss or thinning of the hair
  • hearing loss
  • hiccups
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • pain in the chest below the breastbone
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • weight loss
Less common:
  • Feeling of warmth
  • pain or discomfort in chest, upper stomach, or throat
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • unusually warm skin
Rare
  • Abdominal or stomach distension or pain
  • abnormal dreams
  • blemishes on the skin
  • bumps on the skin
  • burning, dry, or itching eyes
  • change in taste
  • change in walking and balance
  • clumsiness or unsteadiness
  • confusion about identity, place, and time
  • difficulty with moving
  • discharge, excessive tearing
  • excess air or gas in the stomach
  • extreme thirst
  • false or unusual sense of well-being
  • flushed, dry skin
  • frequent urination
  • fruit-like breath odor
  • full feeling
  • heartburn
  • increased hunger
  • increased sensitivity of the skin to sunlight
  • increased urination
  • increased volume of pale, dilute urine
  • joint pain
  • muscle aching or cramping
  • muscle stiffness or weakness
  • oily skin
  • passing gas
  • pimples
  • redness or other discoloration of the skin
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • severe constipation
  • severe sunburn
  • sleepiness
  • sweating
  • swollen joints
  • trouble performing routine tasks
  • trouble sleeping
  • unexplained weight loss
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • weight gain
  • white patches in the mouth or throat or on the tongue
  • white patches with diaper rash

For Healthcare Professionals

Applies to fosaprepitant: intravenous powder for injection

General

The most common side effects include fatigue and diarrhea.[Ref]

Other

Very common (10% or more): Fatigue (up to 15%)
Common (1% to 10%): Asthenia, pyrexia
Uncommon (0.1% to 1%): Malaise
Rare (0.01% to 0.1%): Candidiasis, staphylococcal infection, tinnitus
Frequency not reported: Postoperative infection, wound dehiscence, hypothermia, pain[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 13%)
Common (1% to 10%): Dyspepsia, constipation
Uncommon (0.1% to 1%): Abdominal pain, gastroesophageal reflux disease, nausea, eructation, vomiting, dry mouth, flatulence
Rare (0.01% to 0.1%): Duodenal ulcer perforation, stomatitis, hard feces, neutropenic colitis, abdominal distension
Frequency not reported: Abdominal pain upper, bowel sounds abnormal, stomach discomfort, subileus[Ref]

Constipation and subileus occurred at higher doses.[Ref]

Hematologic

Common (1% to 10%): Neutropenia, anemia, leukopenia
Uncommon (0.1% to 1%): Febrile neutropenia
Rare (0.01% to 0.1%): Neutrophil count decreased
Frequency not reported: hemoglobin decreased, blood albumin decreased[Ref]

Local

Common (1% to 10%): Infusion-site reactions, infusion site pain
Uncommon (0.1% to 1%): Injection site irritation, vessel puncture-site pain, infusion site thrombophlebitis, infusion site erythema, infusion site pruritus, infusion site induration[Ref]

Infusion site reactions occurred in 2.2% of patients, compared to 0.6% given ondansetron and dexamethasone (standard therapy). These reactions included infusion site pain, injection site irritation, vessel-puncture site pain, and infusion site thrombophlebitis.[Ref]

Hepatic

Common (1% to 10%): ALT increased, AST increased
Frequency not reported: Blood bilirubin increased[Ref]

Nervous system

Common (1% to 10%): Peripheral neuropathy, headache
Uncommon (0.1% to 1%): Dizziness, somnolence
Rare (0.01% to 0.1%): Cognitive disorder, lethargy, gait disturbance, dysgeusia
Frequency not reported: Hypoesthesia, syncope, sensory disturbance, dysarthria
Postmarketing reports: Ifosfamide-induced neurotoxicity[Ref]

Ifosfamide-induced neurotoxicity occurred after coadministration with ifosfamide.[Ref]

Cardiovascular

Common (1% to 10%): Bradycardia
Uncommon (0.1% to 1%): Blood pressure increased/hypertension, blood pressure decreased/hypotension, thrombophlebitis, palpitations, hot flush
Rare (0.01% to 0.1%): Cardiovascular disorder, chest discomfort, edema
Frequency not reported: Operative hemorrhage, hematoma[Ref]

Metabolic

Common (1% to 10%): Decreased appetite
Uncommon (0.1% to 1%): Blood alkaline phosphatase increased
Rare (0.01% to 0.1%): Polydipsia, blood sodium decreased, weight decrease
Frequency not reported: blood glucose increased, blood potassium decreased/hypokalemia, hypovolemia[Ref]

Respiratory

Common (1% to 10%): Hiccups
Rare (0.01% to 0.1%): Cough, oropharyngeal pain, postnasal drip, sneezing, throat irritation
Frequency not reported: Dyspnea, respiratory depression, hypoxia, wheezing[Ref]

Psychiatric

Common (1% to 10%): Insomnia
Uncommon (0.1% to 1%): Anxiety
Rare (0.01% to 0.1%): Disorientation, euphoric mood[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Dysuria
Rare (0.01% to 0.1%): Pollakiuria, red blood cells urine positive, glucose urine present, urine output increased[Ref]

Musculoskeletal

Common (1% to 10%): Pain in extremity
Rare (0.01% to 0.1%) Muscular weakness, muscle spasms[Ref]

Dermatologic

Uncommon (0.1% to 1%): Erythema, flushing, acne, rash
Rare (0.01% to 0.1%): Hyperhidrosis, seborrhea, photosensitivity reaction, rash pruritic, skin lesion, Stevens-Johnson syndrome, toxic epidermal necrolysis
Postmarketing reports: Pruritus, urticaria[Ref]

Ocular

Rare (0.01% to 0.1%): Conjunctivitis
Frequency not reported: Visual acuity reduced, miosis[Ref]

Hypersensitivity

Frequency not reported: Angioedema
Postmarketing reports: Hypersensitivity reactions, anaphylactic reactions[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Emend for Injection (fosaprepitant)." Merck & Company Inc, West Point, PA.

Not all side effects for fosaprepitant may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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