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Fluocinolone ophthalmic Side Effects

Medically reviewed by Last updated on Jan 10, 2024.

Applies to fluocinolone ophthalmic: intraocular implant.

Serious side effects

Along with its needed effects, fluocinolone ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fluocinolone ophthalmic:

More common

Other side effects

Some side effects of fluocinolone ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to fluocinolone ophthalmic: intravitreal implant.


The most frequently reported side effects were cataract operation, cataract, and increased intraocular pressure.[Ref]


Very common (10% or more): Cataract (82%), cataract operation (up to 80%), increased intraocular pressure (up to 34%), myodesopsia (21%), eye pain (15%), conjunctival hemorrhage (13%)

Common (1% to 10%): Glaucoma, vitreous hemorrhage, conjunctival hemorrhage, blurred vision, reduced visual acuity, vitreous floaters, trabeculectomy, vitrectomy, trabeculoplasty, eye irritation, conjunctivitis, corneal edema, foreign body sensation in eyes, ocular hyperemia, ocular discomfort, photophobia, anterior chamber cell, blepharitis, choroidal detachment, diplopia, hyphema

Uncommon (0.1% to 1%): Endophthalmitis, retinal vascular occlusion, optic nerve disorder, maculopathy, optic atrophy, conjunctival ulcer, iris neovascularization, retinal exudates, vitreous degeneration, vitreous detachment, posterior capsule opacification, iris adhesion, sclera thinning, eye discharge, eye pruritus, removal of extruded implant from sclera[Ref]


Uncommon (0.1% to 1%): Extrusion of implant, implant in line of sight, procedural complication, procedural pain, device dislocation[Ref]


Common (1% to 10%): Pneumonia, nasopharyngitis, sinusitis, upper respiratory tract infection, influenza, cough[Ref]


Common (1% to 10%): Arthralgia, back pain, limb pain[Ref]

Nervous system

Very common (10% or more): Headache (33%)

Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Vomiting, nausea[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Anemia (11%)[Ref]


Common (1% to 10%): Renal failure[Ref]

Frequently asked questions


1. (2005) "Product Information. Retisert (fluocinolone ophthalmic)." Bausch and Lomb Americas, Inc.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.