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Estramustine Side Effects

For the Consumer

Applies to estramustine: oral capsule

Along with its needed effects, estramustine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking estramustine:

  • Black, tarry stools
  • blood in urine or stools
  • cough or hoarseness
  • fever or chills
  • headaches (severe or sudden)
  • loss of coordination (sudden)
  • lower back or side pain
  • painful or difficult urination
  • pains in chest, groin, or leg (especially calf of leg)
  • pinpoint red spots on skin
  • shortness of breath (sudden, for no apparent reason)
  • slurred speech (sudden)
  • unusual bleeding or bruising
  • vision changes (sudden)
  • weakness or numbness in arm or leg

Check with your doctor as soon as possible if any of the following side effects occur while taking estramustine:

More common
  • Swelling of feet or lower legs
  • Skin rash or fever
  • unusual tiredness or weakness

Some side effects of estramustine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Breast tenderness or enlargement
  • decreased interest in sex
  • diarrhea
  • nausea
Less common

For Healthcare Professionals

Applies to estramustine: oral capsule


Very common (10% or more): Breast tenderness (66%), breast enlargement (60%), gynecomastia
Frequency not reported: Erectile dysfunction[Ref]


Very common (10% or more): Abnormal LDH and/or AST (31%), abnormal hepatic function
Common (1% to 10%): Abnormal bilirubin[Ref]


Very common (10% or more): Edema (19%)
Common (1% to 10%): Chest pain
Frequency not reported: Injection site thrombosis[Ref]


Very common (10% or more): Nausea (15%), diarrhea (12%), minor gastrointestinal upset (11%), vomiting
Common (1% to 10%): Flatulence, gastrointestinal bleeding[Ref]


Very common (10% or more): Dyspnea (11%)
Common (1% to 10%): Pulmonary emboli, upper respiratory discharge, hoarseness, burning throat
Frequency not reported: Larynx edema[Ref]


Very common (10% or more): Congestive heart failure
Common (1% to 10%): Myocardial infarction, thrombophlebitis
Frequency not reported: Myocardial ischemia, hypertension[Ref]


Very common (10% or more): Anemia, leukopenia
Common (1% to 10%): Thrombocytopenia[Ref]


Very common (10% or more): Fluid retention
Common (1% to 10%): Anorexia, thirst[Ref]


Common (1% to 10%): Pruritus, dry skin, rash, easy bruising, flushing, peeling skin on fingertip, thinning hair[Ref]


Common (1% to 10%): Leg cramps
Frequency not reported: Muscular weakness[Ref]

Nervous system

Common (1% to 10%): Lethargy, cerebrovascular accident, headache[Ref]


Common (1% to 10%): Tearing of eyes[Ref]


Common (1% to 10%): Insomnia, emotional lability, anxiety
Frequency not reported: Confusional state, depression[Ref]


Frequency not reported: Hypersensitivity reactions, allergic reactions, angioedema, allergic dermatitis[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Emcyt (estramustine)." Pharmacia and Upjohn, Kalamazoo, MI.

Some side effects of estramustine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.