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Eslicarbazepine Side Effects

In Summary

Commonly reported side effects of eslicarbazepine include: ataxia, blurred vision, diplopia, dizziness, drowsiness, equilibrium disturbance, headache, nausea, tremor, vertigo, abnormal gait, asthenia, fatigue, hypersomnia, nystagmus, sedation, visual disturbance, and malaise. Other side effects include: psychomotor retardation, hyponatremia, amnesia, aphasia, cognitive dysfunction, confusion, disorientation, memory impairment, mental disorders, and speech disturbance. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to eslicarbazepine: oral tablet

In addition to its needed effects, some unwanted effects may be caused by eslicarbazepine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking eslicarbazepine:

Less common:
  • Confusion
  • decreased urine output
  • dizziness
  • fast or irregular heartbeat
  • fever or chills
  • increased in seizure frequency or severity
  • muscle pain or cramps
  • nausea or vomiting
  • severe thirst
  • shortness of breath
  • swelling of the face, ankles, or hands
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unusual tiredness or weakness
Incidence not known:
  • Abdominal or stomach pain
  • blistering, peeling, or loosening of the skin
  • bloating of the abdomen or stomach
  • changes in behavior
  • discouragement
  • difficulty breathing
  • difficulty swallowing
  • feeling sad or empty
  • hives, rash, or itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid, shallow breathing
  • red skin lesions, often with a purple center
  • sores, ulcers, or white spots in the mouth or on the lips
  • thoughts or attempts at killing oneself
  • upper right abdominal or stomach pain
  • yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with eslicarbazepine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Blurred vision
  • double vision
  • sensation of spinning or constant movement
  • sleepiness
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
Less common:
  • Changes in patterns and rhythms of speech
  • heartburn or indigestion
  • irritability
  • loss of interest or pleasure
  • lower back or side pain
  • shakiness and unsteady walk
  • shakiness in the legs, arms, hands, or feet
  • tingling of the hands or feet
  • trembling or shaking of the hands or feet
  • trouble concentrating
  • unusual weight gain or loss

For Healthcare Professionals

Applies to eslicarbazepine: oral tablet


Common (1% to 10%): Hypertension
Frequency not reported: Palpitations, bradycardia, tachycardia, hypotension, peripheral edema, PR interval prolongation[Ref]


Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Alopecia, dry skin, hyperhidrosis, erythema, skin disorder, pruritus
Frequency not reported: Drug reaction with eosinophilia and systemic symptoms (DRESS), nail disorder[Ref]


Very common (10% or more): Nausea (up to 16%), vomiting (up to 10%)
Common (1% to 10%): Diarrhea, constipation, abdominal pain
Uncommon (0.1% to 1%): Gastritis, dyspepsia, dry mouth, abdominal discomfort, abdominal distension, gingivitis, melena, toothache
Frequency not reported: Duodenitis, epigastric discomfort, irritable bowel syndrome, odynophagia, stomatitis, increased appetite, decreased appetite, and ageusia[Ref]


Uncommon (0.1% to 1%): Urinary tract infection[Ref]


Uncommon (0.1% to 1%): Anemia
Rare (less than 0.1%): Thrombocytopenia, leukopenia
Frequency not reported: Decreased hematocrit, decreased hemoglobin[Ref]


Common (1% to 10%): Hyponatremia, decreased appetite
Uncommon (0.1% to 1%): Electrolyte imbalance, dehydration, hypochloremia[Ref]


Common (1% to 10%): Falls, asthenia
Uncommon (0.1% to 1%): Myalgia, bone metabolism disorder, muscular weakness, pain in extremity, back pain, neck pain[Ref]

Nervous system

Very common (10% or more): Dizziness (up to 28%), somnolence (up to 18%), headache (up to 15%)
Common (1% to 10%): Vertigo, ataxia, balance disorder, tremor, dysarthria, memory impairment
Uncommon (0.1% to 1%): Coordination abnormal, memory impairment, amnesia, hypersomnia, sedation, aphasia, dysesthesia, dystonia, lethargy, parosmia, cerebellar syndrome, convulsion, peripheral neuropathy, nystagmus, speech disorder, dysarthria, burning sensation, paresthesia, migraine[Ref]


Very common (10% or more): Diplopia (up to 11%)
Common (1% to 10%): Blurred vision, visual impairment
Frequency not reported: Oscillopsia, binocular eye movement disorder, ocular hyperemia, saccadic eye movement, eye pain[Ref]


Common (1% to 10%): Depression, insomnia
Uncommon (0.1% to 1%): Apathy, depression, nervousness, agitation, irritability, attention deficit/hyperactivity disorder, confusional state, mood swings, crying, psychomotor retardation, psychotic disorder[Ref]


Common (1% to 10%): Cough
Uncommon (0.1% to 1%): Epistaxis, chest pain
Frequency not reported: Dysphonia[Ref]


Uncommon (0.1% to 1%): Hypothyroidism[Ref]


Uncommon (0.1% to 1%): Liver disorder
Frequency not reported: Increased transaminases[Ref]


Common (1% to 10%): Fatigue, asthenia, gait disturbance, peripheral edema
Uncommon (0.1% to 1%): Malaise, chills[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Aptiom (eslicarbazepine)." Sunovion Pharmaceuticals Inc, Marlborough, MA.

Not all side effects for eslicarbazepine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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