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Enzalutamide Side Effects

Medically reviewed by Last updated on May 3, 2024.

Applies to enzalutamide: oral capsule liquid filled, oral tablet.

Serious side effects of Enzalutamide

Along with its needed effects, enzalutamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enzalutamide:

More common

Less common


Incidence not known

Other side effects of Enzalutamide

Some side effects of enzalutamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to enzalutamide: oral capsule, oral tablet.

Nervous system

Very common (10% or more): Headache (12%), dizziness/vertigo (11%)

Common (1% to 10%): Spinal cord compression and cauda equina syndrome, paresthesia, hypoesthesia, dysgeusia, restless legs syndrome

Uncommon (0.1% to 1%): Seizures

Postmarketing reports: Posterior reversible encephalopathy syndrome (PRES) (e.g., seizure, headache, lethargy, confusion, blindness, and other visual and neurological disturbances, with or without associated hypertension)[Ref]


Very common (10% or more): Hot flush (20%), peripheral edema (15%), hypertension (14%)[Ref]


Common (1% to 10%): Pruritus, dry skin

Postmarketing reports: Rash[Ref]


Common (1% to 10%): Gynecomastia[Ref]


Very common (10% or more): Constipation (23%), diarrhea (22%)

Common (1% to 10%): Hematuria, pollakiuria

Postmarketing reports: Vomiting[Ref]


Common (1% to 10%): Hematuria, pollakiuria[Ref]


Very common (10% or more): Neutropenia (15%)

Common (1% to 10%): Thrombocytopenia

Frequency not reported: Leukopenia[Ref]


Very common (10% or more): ALT elevations (10%)

Common (1% to 10%): Bilirubin elevations[Ref]


Very common (10% or more): Decreased appetite (19%), decreased weight (12%)[Ref]


Very common (10% or more): Back pain (29%), arthralgia (21%), musculoskeletal pain (15%)

Common (1% to 10%): Muscular weakness, musculoskeletal stiffness[Ref]


Very common (10% or more): Asthenia/fatigue (51%), falls (13%)

Common (1% to 10%): Fall-related injuries[Ref]


Common (1% to 10%): Insomnia, anxiety, hallucinations, mental impairment disorders[Ref]


Very common (10% or more): Upper respiratory tract infection (16%), dyspnea (11%)

Common (1% to 10%): Lower respiratory tract and lung infection, epistaxis[Ref]


Postmarketing reports: Face edema, tongue edema, lip edema, pharynx edema[Ref]


Postmarketing reports: Blindness and other visual disturbances due to posterior reversible encephalopathy syndrome (PRES)[Ref]

Frequently asked questions


1. (2012) "Product Information. Xtandi (enzalutamide)." Astellas Pharma US, Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.