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Dyrenium Side Effects

Generic name: triamterene

Medically reviewed by Last updated on Apr 19, 2024.

Note: This document contains side effect information about triamterene. Some dosage forms listed on this page may not apply to the brand name Dyrenium.

Applies to triamterene: oral capsule.


Oral route (Capsule)

May cause hyperkalemia, which if uncorrected, is potentially fatal. Hyperkalemia is more likely to occur in patients with renal impairment, diabetes mellitus (with or without recognized renal insufficiency), and in the elderly or severely ill. Monitor serum potassium levels carefully in any patient receiving triamterene.

Serious side effects of Dyrenium

Along with its needed effects, triamterene (the active ingredient contained in Dyrenium) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking triamterene:

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking triamterene:

Symptoms of overdose

Other side effects of Dyrenium

Some side effects of triamterene may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to triamterene: compounding powder, oral capsule.


Uncommon (0.1% to 1%): Rash

Rare (less than 0.1%): Photosensitivity reactions, pseudoporphyria[Ref]


Uncommon (0.1% to 1%): Hypovolemia[Ref]


Frequency not reported: Blue fluorescence of the urine under certain light conditions[Ref]


Rare (less than 0.1%): Thrombocytopenia, megaloblastic anemia, pancytopenia[Ref]


Rare (less than 0.1%): Jaundice and/or liver enzyme abnormalities[Ref]


Rare (less than 0.1%): Anaphylaxis, photosensitivity[Ref]


Very common (10% or more): Hyperkalemia

Uncommon (0.1% to 1%): Hyperuricemia

Rare (less than 0.1%): Hypokalemia, metabolic acidosis[Ref]

Nervous system

Uncommon (0.1% to 1%): Headache

Rare (less than 0.1%): Dizziness[Ref]


Rare (less than 0.1%): Weakness, fatigue, serum sickness[Ref]


Uncommon (0.1% to 1%): Elevation of serum creatinine, transient renal insufficiency

Rare (0.01% to 0.1%): Interstitial nephritis, urinary stones, azotemia, elevated BUN and creatinine, renal stones, acute interstitial nephritis

Very rare (less than 0.01%): Renal failure[Ref]


1. (2001) "Product Information. Dyrenium (triamterene)." SmithKline Beecham

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.