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Dyrenium Side Effects

Generic name: triamterene

Medically reviewed by Last updated on Apr 19, 2022.

Note: This document contains side effect information about triamterene. Some dosage forms listed on this page may not apply to the brand name Dyrenium.

Applies to triamterene: oral capsules, oral fixed-dose combination formulations.


  • Hyperkalemia (i.e., serum potassium concentrations ≥5.5 mEq/L) may occur with all potassium-sparing agents, including triamterene.b c d More likely to occur in patients with renal impairment and diabetes (even without evidence of renal impairment), and in geriatric or severely ill patients or those receiving prolonged therapy with large doses.a b c d

  • Uncorrected hyperkalemia may be fatal; monitor serum potassium concentrations at frequent intervals especially during initial therapy, after dosage adjustment, or in patients with concurrent illness that may affect renal function.b c d

Side effects include:

Hyperkalemia, azotemia, increased BUN and creatinine, renal calculi, jaundice and/or liver enzyme abnormalities, nausea and vomiting, diarrhea, thrombocytopenia, megaloblastic anemia, weakness, fatigue, dizziness, headache, dry mouth.

For Healthcare Professionals

Applies to triamterene: compounding powder, oral capsule.


Uncommon (0.1% to 1%): Rash

Rare (less than 0.1%): Photosensitivity reactions, pseudoporphyria[Ref]


Uncommon (0.1% to 1%): Hypovolemia[Ref]


Frequency not reported: Blue fluorescence of the urine under certain light conditions[Ref]


Rare (less than 0.1%): Thrombocytopenia, megaloblastic anemia, pancytopenia[Ref]


Rare (less than 0.1%): Jaundice and/or liver enzyme abnormalities[Ref]


Rare (less than 0.1%): Anaphylaxis, photosensitivity[Ref]


Very common (10% or more): Hyperkalemia

Uncommon (0.1% to 1%): Hyperuricemia

Rare (less than 0.1%): Hypokalemia, metabolic acidosis[Ref]

Nervous system

Uncommon (0.1% to 1%): Headache

Rare (less than 0.1%): Dizziness[Ref]


Rare (less than 0.1%): Weakness, fatigue, serum sickness[Ref]


Uncommon (0.1% to 1%): Elevation of serum creatinine, transient renal insufficiency

Rare (0.01% to 0.1%): Interstitial nephritis, urinary stones, azotemia, elevated BUN and creatinine, renal stones, acute interstitial nephritis

Very rare (less than 0.01%): Renal failure[Ref]


1. "Product Information. Dyrenium (triamterene)." SmithKline Beecham (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.