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Generic name: triamterenetry-AM-teh-reen ]
Drug class: Potassium-sparing diuretics

Medically reviewed by on Mar 22, 2024. Written by Cerner Multum.

What is Dyrenium?

Dyrenium is a potassium-sparing diuretic (water pill) that is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney condition called nephrotic syndrome.

Dyrenium is also used to treat edema caused by using steroid medicine or having too much aldosterone in your body. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in your body.

Dyrenium may also be used for purposes not listed in this medication guide.

Dyrenium side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dyrenium may cause serious side effects. Stop using Dyrenium and call your doctor at once if you have:

Common side effects of Dyrenium may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use Dyrenium if you have severe kidney or liver disease, urination problems, or high levels of potassium in your blood. You should not take Dyrenium if you also take potassium supplements, or other diuretics such as amiloride or spironolactone.

Call your doctor right away if you have signs of hyperkalemia (high potassium), such as nausea, irregular heartbeats, weakness, or loss of movement. High potassium may be more likely in older adults, or in people with kidney disease, diabetes, or severe illness.

Before taking this medicine

You should not use Dyrenium if you are allergic to it, or if you have:

Tell your doctor if you have ever had:

Using Dyrenium may increase your risk of developing hyperkalemia (high levels of potassium in your blood). High potassium may be more likely in older adults, or in people with kidney disease, diabetes, or severe illness.

Tell your doctor if you are pregnant or if you become pregnant. Dyrenium may harm an unborn baby. However, the benefit of treating edema during pregnancy may outweigh the risk to the baby.

You should not breastfeed while using Dyrenium.

Dyrenium is not approved for use by anyone younger than 18 years old.

How should I take Dyrenium?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take Dyrenium after eating a meal to avoid stomach upset.

Taking a diuretic can make you urinate more often, which could disrupt your sleep. If you take Dyrenium only once per day, take it in the morning to reduce the chance of night-time urination.

You may need frequent medical tests. Your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Dyrenium.

If you need surgery, tell the surgeon ahead of time that you are using Dyrenium.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include increased nausea, vomiting, unusual heart rate, muscle weakness, or loss of movement.

What should I avoid while taking Dyrenium?

Avoid driving or hazardous activity until you know how Dyrenium will affect you. Your reactions could be impaired.

Drinking alcohol with this medicine can cause side effects.

Dyrenium could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

What other drugs will affect Dyrenium?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect Dyrenium, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.