DynaCirc CR Side Effects
Generic name: isradipine
Medically reviewed by Drugs.com. Last updated on Oct 8, 2022.
Note: This document contains side effect information about isradipine. Some dosage forms listed on this page may not apply to the brand name DynaCirc CR.
Applies to isradipine: oral capsule.
Serious side effects of DynaCirc CR
Along with its needed effects, isradipine (the active ingredient contained in DynaCirc CR) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking isradipine:
- Bloating or swelling of face, arms, hands, lower legs, or feet
- tingling of hands or feet
- unusual weight gain or loss
- Chest pain
- difficult or labored breathing
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of warmth
- full or bloated feeling
- pressure in the stomach
- redness of the face, neck, arms and occasionally, upper chest
- shortness of breath
- swelling of abdominal or stomach area
- tightness in chest
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur while taking isradipine:
Symptoms of Overdose
- Blurred vision
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
Other side effects of DynaCirc CR
Some side effects of isradipine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- difficulty having a bowel movement (stool)
- stomach soreness or discomfort
For Healthcare Professionals
Applies to isradipine: oral capsule, oral tablet extended release.
Isradipine (the active ingredient contained in DynaCirc CR) is generally well-tolerated. Most side effects occurred as commonly as with placebo in placebo-controlled trials, except for flushing, headache, and palpitations.[Ref]
Palpitations or a greater awareness of heart beats is reported in 1% to 5% of patients. Flushing and palpitations are more likely with dosages greater than 5 mg daily; women have reported flushing more than men. Edema was reported in up to 22% of patients in one study (mean dose was 5.9 mg TID). In large studies, the incidence of edema is less than 3%, and appeared to be more likely in patients greater than 60 years of age.
Isradipine (the active ingredient contained in DynaCirc CR) does not appear to adversely affect plasma lipids.[Ref]
Cardiovascular side effects are among the most common, and are related to the vasodilatory properties of isradipine. Peripheral edema and flushing are reported in 3% to 14% of patients, being more common at higher doses. Dizziness occurs in 3% to 8% of patients.[Ref]
Nervous system side effects are probably related to the vasodilatory effects of isradipine (the active ingredient contained in DynaCirc CR) Headache is reported in 9% to 30% of patients and fatigue is reported in 7% of patients.[Ref]
Headache was reported in up to 16% of patients in one study, although the mean dose was 5.9 mg three times daily to treat angina pectoris. Headache is more likely with dosages greater than 5 mg daily. Visual disturbances are reported in less than 2% of patients. Sleep disturbances are reported in 0.1% of patients.[Ref]
Musculoskeletal pain is reported in 1% of patients.[Ref]
Dermatologic complaints of "disturbed skin sensation" are reported in less than 4% of patients.[Ref]
More about DynaCirc CR (isradipine)
- Check interactions
- Reviews (1)
- Drug images
- Dosage information
- During pregnancy
- Drug class: calcium channel blocking agents
Related treatment guides
1. "Multum Information Services, Inc. Expert Review Panel"
2. Lind L, Berne C, Pollare T, Lithell H "Metabolic effects of isradipine as monotherapy or in combination with pindolol during long-term antihypertensive treatment." J Intern Med 236 (1994): 37-42
3. Chrysant SG, Cohen M "Sustained blood pressure control with controlled-release isradipine (isradipine-CR)." J Clin Pharmacol 35 (1995): 239-43
4. Batlouni M, Armaganijan D, Ghorayeb N, Magliano MF "Clinical efficacy and tolerability of isradipine in the treatment of mild-to-moderate hypertension in young and elderly patients." J Cardiovasc Pharmacol 19 (1992): s53-7
5. Walton T, Symes LR "Felodipine and isradipine: new calcium-channel-blocking agents for the treatment of hypertension." Clin Pharm 12 (1993): 261-75
6. Sundstedt CD, Ruegg PC, Keller A, Waite R "A multicenter evaluation of the safety, tolerability, and efficacy of isradipine in the treatment of essential hypertension." Am J Med 86 (1989): 98-102
7. Ruegg PC, Nelson DJ "Safety and efficacy of isradipine, alone and in combination, in the treatment of angina pectoris." Am J Med 86 (1989): 70-4
8. De Keyser P, Bouve J, Clement D, Degraef R, Meurant JP, Rorive G, Van Thillo J "Isradipine in essential hypertension: the Belgian General Practitioners' Study." Am J Med 86 (1989): 103-9
9. Yodfat Y, Cristal N "A multicenter, double-blind, randomized, placebo-controlled study of isradipine and methyldopa as monotherapy or in combination with captopril in the treatment of hypertension. The LOMIR-MCT-IH ResearchGroup." Am J Hypertens 6 (1993): s57-61
10. Samad A, Khan AH, Hashmi MS "Efficacy, safety, and tolerability of isradipine in hypertension as used in general practice in a developing country (Pakistan)." Am J Hypertens 6 (1993): s54-6
11. Luomanmaki K, Inkovaara J, Hartikainen M, Helin M, Viikari J, Kataja M, Ekman K, Harjula K "Efficacy and tolerability of isradipine and metoprolol in treatment of hypertension: the Finnish Isradipine Study in Hypertension (FISH)." J Cardiovasc Pharmacol 20 (1992): 296-303
12. Hermans L, Bogaert M, Degaute JP, Rorive G, Six R, Bara L, Lanssiers P, De Keyser P, Westelinck KJ "Tolerability of isradipine in the treatment of mild-to-moderate hypertension in general practice: a large-scale surveillance study." J Cardiovasc Pharmacol 19 (1992): s38-45
13. Marcus AO "Antihypertensive therapy with the calcium channel blocker isradipine - an appropriate choice for the diabetic patient with hypertension - a review." Curr Ther Res Clin Exp 54 (1993): 763-778
14. Farsang C, Kapocsi J, Kiss I, Torok E, Kerkovits G, Hollo J, Javor T "Hungarian isradipine study (HIS): long-term (3-year) effects on blood pressure and plasma lipids." Am J Hypertens 7 Suppl 7 (1994): s56-60
15. Rochagoncalves F, Moura B, Pereiramiguel JM, Correanunes A, Marianopego G "Isradipine in the treatment of mild-to-moderate hypertension in geriatric patients." Am J Hypertens 7 Suppl 7 (1994): s64-6
16. Weiss RJ "A large, prospective, open-label study of isradipine in patients with essential hypertension." Clin Ther 16 (1994): 647-52
17. Hermans L, Deblander A, Dekeyser P, Scheys I, Lesaffre E, Westelinck KJ "At equipotent doses, isradipine is better tolerated than amlodipine in patients with mild-to-moderate hypertension: a double-blind, randomized, parallel-group study." Br J Clin Pharmacol 38 (1994): 335-40
18. Blecker D "Antihypertensive therapy with isradipine in patients with special safety concerns." Angiology 45 (1994): 997-1008
19. Chrysant SG, Cohen M "Sustained blood pressure control with controlled-release isradipine." Am J Hypertens 8 (1995): 87-9
20. Brogden RN, Sorkin EM "Isradipine: an update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of mild to moderate hypertension." Drugs 49 (1995): 618-49
21. Kubota K, Pearce GL, Inman WHW "Vasodilation-related adverse events in diltiazem and dihydropyridine calcium antagonists studied by prescription-event monitoring." Eur J Clin Pharmacol 48 (1995): 1-7
22. Johnson BF, Eisner GM, Mcmahon FG, Jain AK, Rudd P, Sowers JR "A multicenter comparison of adverse reaction profiles of isradipine and enalapril at equipotent doses in patients with essential hypertension." J Clin Pharmacol 35 (1995): 484-92
23. Tomlinson B, Woo J, Critchley JAJH, Or KKH, Chan TYK, Sanderson JE "Sustained-release isradipine compared with spirapril in the treatment of elderly patients with isolated systolic hypertension." Am J Hypertens 7 Suppl 7 (1994): s35-9
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.