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DynaCirc CR Side Effects

Generic Name: isradipine

Note: This page contains information about the side effects of isradipine. Some of the dosage forms included on this document may not apply to the brand name DynaCirc CR.

For the Consumer

Applies to isradipine: oral capsule, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by isradipine (the active ingredient contained in DynaCirc CR). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking isradipine:

More common:
  • Bloating or swelling of face, arms, hands, lower legs, or feet
  • tingling of hands or feet
  • unusual weight gain or loss
Less common:
  • Chest pain
  • difficult or labored breathing
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • full or bloated feeling
  • nausea
  • pressure in the stomach
  • redness of the face, neck, arms and occasionally, upper chest
  • shortness of breath
  • swelling of abdominal or stomach area
  • tightness in chest
  • unusual tiredness or weakness
  • vomiting
  • wheezing

If any of the following symptoms of overdose occur while taking isradipine, get emergency help immediately:

Symptoms of overdose:
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • flushing
  • sweating

Minor Side Effects

Some of the side effects that can occur with isradipine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Headache
Less common:
  • Diarrhea
  • difficulty having a bowel movement (stool)
  • rash
  • stomach soreness or discomfort

For Healthcare Professionals

Applies to isradipine: oral capsule, oral tablet extended release


Isradipine (the active ingredient contained in DynaCirc CR) is generally well-tolerated. Most side effects occurred as commonly as with placebo in placebo-controlled trials, except for flushing, headache, and palpitations.[Ref]


Cardiovascular side effects are among the most common, and are related to the vasodilatory properties of isradipine (the active ingredient contained in DynaCirc CR) Peripheral edema and flushing are reported in 3% to 14% of patients, being more common at higher doses. Dizziness occurs in 3% to 8% of patients.[Ref]

Palpitations or a greater awareness of heart beats is reported in 1% to 5% of patients. Flushing and palpitations are more likely with dosages greater than 5 mg daily; women have reported flushing more than men. Edema was reported in up to 22% of patients in one study (mean dose was 5.9 mg TID). In large studies, the incidence of edema is less than 3%, and appeared to be more likely in patients greater than 60 years of age.

Isradipine does not appear to adversely affect plasma lipids.[Ref]

Nervous system

Headache was reported in up to 16% of patients in one study, although the mean dose was 5.9 mg three times daily to treat angina pectoris. Headache is more likely with dosages greater than 5 mg daily. Visual disturbances are reported in less than 2% of patients. Sleep disturbances are reported in 0.1% of patients.[Ref]

Nervous system side effects are probably related to the vasodilatory effects of isradipine. Headache is reported in 9% to 30% of patients and fatigue is reported in 7% of patients.[Ref]


Anorexia, nausea, vomiting, and diarrhea are reported in less than 4% of patients.[Ref]

Gastrointestinal side effects are unusual, and include constipation in less than 2% of patients.[Ref]


Respiratory system complaints include dyspnea and cough in 2% of patients.[Ref]


Musculoskeletal pain is reported in 1% of patients.[Ref]


Dermatologic complaints of "disturbed skin sensation" are reported in less than 4% of patients.[Ref]


Hypersensitivity reactions to isradipine (the active ingredient contained in DynaCirc CR) are rare. Pruritus, urticaria, and angioedema have been reported.[Ref]


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Not all side effects for DynaCirc CR may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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