Skip to main content

Dutoprol Side Effects

Generic name: hydrochlorothiazide / metoprolol

Medically reviewed by Drugs.com. Last updated on Mar 1, 2023.

Note: This document contains side effect information about hydrochlorothiazide / metoprolol. Some dosage forms listed on this page may not apply to the brand name Dutoprol.

Applies to hydrochlorothiazide / metoprolol: oral tablet.

Serious side effects of Dutoprol

Along with its needed effects, hydrochlorothiazide/metoprolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / metoprolol:

More common

Less common

Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydrochlorothiazide / metoprolol:

Symptoms of overdose

Other side effects of Dutoprol

Some side effects of hydrochlorothiazide / metoprolol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to hydrochlorothiazide / metoprolol: oral tablet, oral tablet extended release.

General

The most common side effects were fatigue, lethargy, flu syndrome, dizziness, vertigo, drowsiness, somnolence, and headache.[Ref]

Gastrointestinal

Common (1% to 10%): Diarrhea, digestive disorder, dry mouth, nausea, vomiting, constipation

Hydrochlorothiazide:

Frequency not reported: Sialadenitis, vomiting, diarrhea, cramping, nausea, gastric irritation, constipation

Metoprolol:

Common (1% to 10%): Diarrhea, nausea, gastric pain, constipation, flatulence, heartburn

Frequency not reported: Vomiting, retroperitoneal fibrosis

Postmarketing reports: Dry mouth[Ref]

Nervous system

Common (1% to 10%): Lethargy, dizziness, drowsiness, somnolence, headache, tinnitus

Hydrochlorothiazide:

Frequency not reported: Dizziness, headache, paresthesia

Metoprolol:

Common (1% to 10%): Tiredness, dizziness

Frequency not reported: Short-term memory loss, headache

Postmarketing reports: Somnolence, paresthesia, syncope, taste disturbance[Ref]

Other

Common (1% to 10%): Fatigue, vertigo, exercise tolerance decreased, edema, earache

Hydrochlorothiazide:

Frequency not reported: Vertigo, weakness

Postmarketing reports: Fever

Metoprolol:

Frequency not reported: Fatigue

Postmarketing reports: Lactic dehydrogenase elevation, alkaline phosphatase elevation, blood triglycerides increased, high-density lipoprotein decreased, tinnitus[Ref]

Metabolic

Common (1% to 10%): Hypokalemia, gout, anorexia

Hydrochlorothiazide:

Frequency not reported: Anorexia, hyperglycemia, hyperuricemia, hypokalemia

Metoprolol:

Frequency not reported: Weight gain[Ref]

Dermatologic

Common (1% to 10%): Sweating, purpura

Hydrochlorothiazide:

Frequency not reported: Stevens-Johnson syndrome, purpura, urticaria, rash, photosensitivity

Postmarketing reports: Erythema multiforme, exfoliative dermatitis, toxic epidermal necrolysis

Metoprolol:

Uncommon (0.1% to 1%): Pruritus

Frequency not reported: Gangrene, rash, photosensitivity, worsening of psoriasis, alopecia

Postmarketing reports: Sweating[Ref]

Gangrene has been reported very rarely in patients with preexisting severe peripheral circulatory disorders who were taking metoprolol.[Ref]

Respiratory

Common (1% to 10%): Dyspnea, nasopharyngitis

Hydrochlorothiazide:

Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema

Metoprolol:

Common (1% to 10%): Shortness of breath

Uncommon (0.1% to 1%): Wheezing

Frequency not reported: Rhinitis

Postmarketing reports: Dyspnea[Ref]

Cardiovascular

Common (1% to 10%): Bradycardia

Hydrochlorothiazide:

Frequency not reported: Orthostatic hypotension, necrotizing angiitis

Metoprolol:

Common (1% to 10%): Bradycardia

Frequency not reported: Cold extremities, arterial insufficiency, palpitations, congestive heart failure

Postmarketing reports: Peripheral edema, chest pain[Ref]

Ocular

Common (1% to 10%): Blurred vision

Hydrochlorothiazide:

Frequency not reported: Transient blurred vision, xanthopsia

Metoprolol:

Postmarketing reports: Blurred vision, dry eyes[Ref]

Psychiatric

Common (1% to 10%): Nightmare

Hydrochlorothiazide:

Frequency not reported: Restlessness

Metoprolol:

Common (1% to 10%): Depression

Frequency not reported: Mental confusion, nightmare, insomnia

Postmarketing reports: Confusional state, anxiety/nervousness, hallucination, libido decreased[Ref]

Genitourinary

Common (1% to 10%): Impotence

Hydrochlorothiazide:

Frequency not reported: Glycosuria

Metoprolol:

Very rare (less than 0.01%): Peyronie's disease

Postmarketing reports: Male impotence[Ref]

Musculoskeletal

Common (1% to 10%): Muscle pain

Hydrochlorothiazide:

Frequency not reported: Muscle spasm

Metoprolol:

Frequency not reported: Arthritis

Postmarketing reports: Musculoskeletal pain, arthralgia[Ref]

Immunologic

Common (1% to 10%): Flu syndrome

Hydrochlorothiazide:

Postmarketing reports: Anaphylactic reactions[Ref]

Hepatic

Frequency not reported: Liver enzymes increased, serum bilirubin increased

Hydrochlorothiazide:

Frequency not reported: Pancreatitis, intrahepatic cholestatic jaundice

Metoprolol:

Postmarketing reports: Hepatitis, jaundice, non-specific hepatic dysfunction, transaminase elevation[Ref]

Hematologic

Hydrochlorothiazide:

Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia[Ref]

Renal

Hydrochlorothiazide:

Postmarketing reports: Interstitial nephritis[Ref]

More about Dutoprol (hydrochlorothiazide / metoprolol)

Patient resources

Other brands

Lopressor HCT

Professional resources

Other brands

Lopressor HCT

Related treatment guides

References

1. Product Information. Lopressor HCT (hydrochlorothiazide-metoprolol). Novartis Pharmaceuticals. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.