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Duradryl Chewable Side Effects

Generic Name: chlorpheniramine / methscopolamine / phenylephrine

Note: This page contains information about the side effects of chlorpheniramine / methscopolamine / phenylephrine. Some of the dosage forms included on this document may not apply to the brand name Duradryl Chewable.

For the Consumer

Applies to chlorpheniramine / methscopolamine / phenylephrine: tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability; headache; increased sweating; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur while taking chlorpheniramine / methscopolamine / phenylephrine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; confusion; difficulty swallowing; difficulty urinating or inability to urinate; fast or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; mental or mood changes; seizures; severe dizziness, drowsiness, lightheadedness, or headache; shortness of breath; tremor; unusual tiredness or weakness.

For Healthcare Professionals

Applies to chlorpheniramine / methscopolamine / phenylephrine: oral capsule extended release, oral liquid, oral suspension extended release, oral syrup, oral tablet, oral tablet chewable, oral tablet chewable extended release, oral tablet extended release

Nervous system

Nervous system side effects of phenylephrine have included headache, dizziness, nervousness, restlessness, tremor, insomnia, convulsions, and central nervous system depression. Antihistamines such as chlorpheniramine and anticholinergics such as methscopolamine may cause drowsiness and dizziness.[Ref]


Cardiovascular side effects of phenylephrine have included palpitations, arrhythmias, and cardiovascular collapse with hypotension.[Ref]


Psychiatric side effects of phenylephrine have included hallucinations, fear, and anxiety.[Ref]


Gastrointestinal side effects of phenylephrine have included nausea. Antihistamines such as chlorpheniramine and anticholinergics such as methscopolamine may cause excessive dryness of the nose, throat, and mouth.[Ref]


Respiratory side effects of phenylephrine have included respiratory difficulty.[Ref]


Genitourinary side effects of phenylephrine have included dysuria.[Ref]


General side effects of phenylephrine have included pallor and weakness.[Ref]


Ocular side effects including blurred vision may be caused by antihistamines such as chlorpheniramine and anticholinergics such as methscopolamine.[Ref]


1. "Product Information. Drize (chlorpheniramine/methscopolamine/PE)." King Pharmaceuticals Inc, Bristol, TN.

2. "Product Information. Ah-Chew D (phenylephrine)." WE Pharmaceuticals Inc, Ramona, CA.

3. "PDR Generics. 4th ed." Montvale, NJ: Medical Economics (1998):

Not all side effects for Duradryl Chewable may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

More about Duradryl Chewable (chlorpheniramine / methscopolamine / phenylephrine)

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