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Dorzolamide ophthalmic Side Effects

Medically reviewed by Last updated on Nov 30, 2023.

Applies to dorzolamide ophthalmic: ophthalmic solution.

Serious side effects

Along with its needed effects, dorzolamide ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dorzolamide ophthalmic:

More common

Less common


Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking dorzolamide ophthalmic:

Symptoms of overdose

Other side effects

Some side effects of dorzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to dorzolamide ophthalmic: ophthalmic solution.


The most commonly reported side effects were ocular burning, stinging, or discomfort, and bitter taste.[Ref]


Very common (10% or more): Superficial punctate keratitis (up to 15%), burning/stinging

Common (1% to 10%): Tearing, conjunctivitis, eyelid inflammation, eye itching, eyelid irritation, blurred vision

Uncommon (0.1% to 1%): Iridocyclitis

Rare (less than 0.1%): Irritation, pain, eyelid crusting, transient myopia, corneal edema, ocular hypotony, choroidal detachment following filtration surgery[Ref]


Very common (10% or more): Ocular allergic reaction (10%)

Rare (less than 0.1%): Signs and symptoms of local reactions (palpebral reactions) and systemic allergic reactions including angioedema, urticaria, pruritus, rash, shortness of breath, bronchospasm[Ref]


Rare (less than 0.1%): Urolithiasis[Ref]


Rare (less than 0.1%): Epistaxis

Frequency not reported: Dyspnea[Ref]


Uncommon (0.1% to 1%): Contact dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis

Rare (less than 0.1%): Skin rash[Ref]

Nervous system

Very common (10% or more): Biter taste (up to 25%)

Frequency not reported: Headache[Ref]


Common (1% to 10%): Nausea

Rare (less than 0.1%): Throat irritation, dry mouth[Ref]


Common (1% to 10%): Asthenia/fatigue[Ref]


1. Product Information. Trusopt (dorzolamide ophthalmic). Merck & Co., Inc. 2001.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.