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Dorzolamide ophthalmic Side Effects

In Summary

Commonly reported side effects of dorzolamide ophthalmic include: burning sensation of eyes, eye discomfort, eye pruritus, local ocular hypersensitivity reaction, stinging of eyes, superficial punctate keratitis, swelling of eye, bitter taste, eye irritation, and eye redness. Other side effects include: blurred vision, lacrimation, photophobia, and xerophthalmia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dorzolamide ophthalmic: ophthalmic solution

Along with its needed effects, dorzolamide ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dorzolamide ophthalmic:

More common
  • Burning, stinging, or discomfort when medicine is applied
  • itching, redness, swelling, or other sign of the eye or eyelid irritation
Less common
  • Burning, dry, or itching eyes
  • discharge from the eye
  • excessive tearing
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
Rare
  • Blood in the urine
  • blurred vision
  • nausea or vomiting
  • pain in the side, back, or abdomen
  • skin rash
  • tearing
Incidence not known
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • change in vision
  • chills
  • cough
  • diarrhea
  • difficult or labored breathing
  • flashes of light
  • floaters in vision
  • hives or welts
  • itching skin
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • redness of the skin
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • tightness in the chest
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking dorzolamide ophthalmic:

Symptoms of overdose
  • Confusion
  • irregular heartbeat
  • muscle cramps or pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • seizures
  • trembling
  • weakness and heaviness of the legs

Some side effects of dorzolamide ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bitter taste
  • feeling of something in the eye
Less common
  • Changes in color vision
  • difficulty seeing at night
  • dryness of the eyes
  • eyelid reactions
  • headache
  • increased sensitivity of the eyes to sunlight
Incidence not known
  • Bloody nose
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in distance vision
  • difficulty in focusing the eyes
  • dizziness
  • dry mouth
  • eyelid crusting
  • lack or loss of strength
  • scaling of the skin
  • severe redness, soreness, or swelling of the skin

For Healthcare Professionals

Applies to dorzolamide ophthalmic: ophthalmic solution

General

The most commonly reported side effects were ocular burning, stinging, or discomfort, and bitter taste.[Ref]

Ocular

Very common (10% or more): Superficial punctate keratitis (up to 15%), burning/stinging
Common (1% to 10%): Tearing, conjunctivitis, eyelid inflammation, eye itching, eyelid irritation, blurred vision
Uncommon (0.1% to 1%): Iridocyclitis
Rare (less than 0.1%): Irritation, pain, eyelid crusting, transient myopia, corneal edema, ocular hypotony, choroidal detachment following filtration surgery[Ref]

Hypersensitivity

Very common (10% or more): Ocular allergic reaction (10%)
Rare (less than 0.1%): Signs and symptoms of local reactions (palpebral reactions) and systemic allergic reactions including angioedema, urticaria, pruritus, rash, shortness of breath, bronchospasm[Ref]

Renal

Rare (less than 0.1%): Urolithiasis[Ref]

Respiratory

Rare (less than 0.1%): Epistaxis
Frequency not reported: Dyspnea[Ref]

Dermatologic

Uncommon (0.1% to 1%): Contact dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis
Rare (less than 0.1%): Skin rash[Ref]

Nervous system

Very common (10% or more): Biter taste (up to 25%)
Frequency not reported: Headache[Ref]

Gastrointestinal

Common (1% to 10%): Nausea
Rare (less than 0.1%): Throat irritation, dry mouth[Ref]

Other

Common (1% to 10%): Asthenia/fatigue[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Trusopt (dorzolamide ophthalmic)." Merck & Co, Inc, West Point, PA.

Some side effects of dorzolamide ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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