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Detrol Side Effects

Generic Name: tolterodine

Note: This page contains information about the side effects of tolterodine. Some of the dosage forms included on this document may not apply to the brand name Detrol.

In Summary

Common side effects of Detrol include: xerostomia. Other side effects include: constipation, dyspepsia, and dizziness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to tolterodine: oral capsule extended release, oral tablet

In addition to its needed effects, some unwanted effects may be caused by tolterodine (the active ingredient contained in Detrol). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking tolterodine:

More common:
  • Abnormal vision, including difficulty with adjusting to distances
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
Less common:
  • Chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • shivering
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest or wheezing
  • trouble with sleeping
  • vomiting
Incidence not known:
  • Being forgetful
  • bloating or swelling of the face, arms, hands, ankles, lower legs, or feet
  • confusion about identity, place, and time
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • mood or mental changes
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Minor Side Effects

Some of the side effects that can occur with tolterodine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Abdominal or stomach pain
  • constipation
  • drowsiness
  • dry eyes
  • dry mouth
  • upset stomach
Less common:
  • Acid or sour stomach
  • belching
  • blurred vision
  • difficulty with moving
  • dizziness or lightheadedness
  • dry skin
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • stomach discomfort
  • weight gain

For Healthcare Professionals

Applies to tolterodine: oral capsule extended release, oral tablet


Uncommon (0.1% to 1%): Palpitations, arrhythmia, abnormal ECG, hypertension
Very rare (less than 0.01%): Cardiac failure
Postmarketing reports: Tachycardia, peripheral edema, flushing[Ref]


Common (1% to 10%): Dry skin, acne, rash/erythema
Postmarketing reports: Angioedema[Ref]


Very common (10% or more): Dry mouth (35%)
Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, ulcerated stomatitis
Frequency not reported: Gastroesophageal reflux, vomiting[Ref]


The most common adverse events reported were dry mouth, headache, constipation, vertigo/dizziness, and abdominal pain. Dry mouth, constipation, abnormal vision (accommodation abnormalities), urinary retention, and xerophthalmia are expected side effects of antimuscarinic agents.[Ref]


Common (1% to 10%): Dysuria, urinary tract infection, micturition frequent
Uncommon (0.1% to 1%): Urinary retention[Ref]


Uncommon (0.1% to 1%): Hypersensitivity not otherwise specified
Postmarketing reports: Anaphylaxis[Ref]


Common (1% to 10%): Influenza-like symptoms, infection[Ref]


Common (1% to 10%): Weight gain, abnormal alkaline phosphatase, enzyme abnormality[Ref]


Common (1% to 10%): Arthralgia, leg pain[Ref]

Nervous system

Common (1% to 10%): Headache, vertigo/dizziness, migraine
Uncommon (0.1% to 1%): Paresthesia, memory impairment
Rare (0.01% to 0.1%): Convulsions[Ref]


Common (1% to 10%): Abnormal accommodation, xerophthalmia, vision abnormal[Ref]


Common (1% to 10%): Fatigue, chest pain, malaise, pain, fall[Ref]


Common (1% to 10%): Somnolence, anxiety
Uncommon (0.1% to 1%): Nervousness
Postmarketing reports: Confusion, disorientation, memory impairment, hallucinations, aggravation of symptoms of dementia (e.g., confusion, disorientation, delusion) after therapy was initiated in patients taking cholinesterase inhibitors for the treatment of dementia[Ref]


Postmarketing reports: Renal dysfunction[Ref]


Common (1% to 10%): Sinusitis, asthma, bronchitis, coughing, dyspnea[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn, Kalamazoo, MI.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Detrol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.