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Detrol Side Effects

Generic name: tolterodine

Medically reviewed by Last updated on Oct 12, 2023.

Note: This document contains side effect information about tolterodine. Some dosage forms listed on this page may not apply to the brand name Detrol.

Applies to tolterodine: oral capsule extended release, oral tablet.

Serious side effects of Detrol

Along with its needed effects, tolterodine (the active ingredient contained in Detrol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tolterodine:

More common

Less common

Incidence not known

Other side effects of Detrol

Some side effects of tolterodine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to tolterodine: oral capsule extended release, oral tablet.


Uncommon (0.1% to 1%): Palpitations, arrhythmia, abnormal ECG, hypertension

Very rare (less than 0.01%): Cardiac failure

Postmarketing reports: Tachycardia, peripheral edema, flushing[Ref]


Common (1% to 10%): Dry skin, acne, rash/erythema

Postmarketing reports: Angioedema[Ref]


Very common (10% or more): Dry mouth (35%)

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, ulcerated stomatitis

Frequency not reported: Gastroesophageal reflux, vomiting[Ref]


The most common adverse events reported were dry mouth, headache, constipation, vertigo/dizziness, and abdominal pain. Dry mouth, constipation, abnormal vision (accommodation abnormalities), urinary retention, and xerophthalmia are expected side effects of antimuscarinic agents.[Ref]


Common (1% to 10%): Dysuria, urinary tract infection, micturition frequent

Uncommon (0.1% to 1%): Urinary retention[Ref]


Uncommon (0.1% to 1%): Hypersensitivity not otherwise specified

Postmarketing reports: Anaphylaxis[Ref]


Common (1% to 10%): Influenza-like symptoms, infection[Ref]


Common (1% to 10%): Weight gain, abnormal alkaline phosphatase, enzyme abnormality[Ref]


Common (1% to 10%): Arthralgia, leg pain[Ref]

Nervous system

Common (1% to 10%): Headache, vertigo/dizziness, migraine

Uncommon (0.1% to 1%): Paresthesia, memory impairment

Rare (0.01% to 0.1%): Convulsions[Ref]


Common (1% to 10%): Abnormal accommodation, xerophthalmia, vision abnormal[Ref]


Common (1% to 10%): Fatigue, chest pain, malaise, pain, fall[Ref]


Common (1% to 10%): Somnolence, anxiety

Uncommon (0.1% to 1%): Nervousness

Postmarketing reports: Confusion, disorientation, memory impairment, hallucinations, aggravation of symptoms of dementia (e.g., confusion, disorientation, delusion) after therapy was initiated in patients taking cholinesterase inhibitors for the treatment of dementia[Ref]


Postmarketing reports: Renal dysfunction[Ref]


Common (1% to 10%): Sinusitis, asthma, bronchitis, coughing, dyspnea[Ref]


1. (2001) "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.