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Detrol LA Side Effects

Generic Name: tolterodine

Note: This document contains side effect information about tolterodine. Some of the dosage forms listed on this page may not apply to the brand name Detrol LA.

For the Consumer

Applies to tolterodine: oral capsule extended release, oral tablet

Along with its needed effects, tolterodine (the active ingredient contained in Detrol LA) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tolterodine:

More common
  • Abnormal vision, including difficulty with adjusting to distances
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
Less common
  • Chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • shivering
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest or wheezing
  • trouble with sleeping
  • vomiting
Incidence not known
  • Being forgetful
  • bloating or swelling of the face, arms, hands, ankles, lower legs, or feet
  • confusion about identity, place, and time
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • mood or mental changes
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some side effects of tolterodine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • constipation
  • drowsiness
  • dry eyes
  • dry mouth
  • upset stomach
Less common
  • Acid or sour stomach
  • belching
  • blurred vision
  • difficulty with moving
  • dizziness or lightheadedness
  • dry skin
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • stomach discomfort
  • weight gain

For Healthcare Professionals

Applies to tolterodine: oral capsule extended release, oral tablet

Cardiovascular

Uncommon (0.1% to 1%): Palpitations, arrhythmia, abnormal ECG, hypertension
Very rare (less than 0.01%): Cardiac failure
Postmarketing reports: Tachycardia, peripheral edema, flushing[Ref]

Dermatologic

Common (1% to 10%): Dry skin, acne, rash/erythema
Postmarketing reports: Angioedema[Ref]

Gastrointestinal

Very common (10% or more): Dry mouth (35%)
Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, ulcerated stomatitis
Frequency not reported: Gastroesophageal reflux, vomiting[Ref]

General

The most common adverse events reported were dry mouth, headache, constipation, vertigo/dizziness, and abdominal pain. Dry mouth, constipation, abnormal vision (accommodation abnormalities), urinary retention, and xerophthalmia are expected side effects of antimuscarinic agents.[Ref]

Genitourinary

Common (1% to 10%): Dysuria, urinary tract infection, micturition frequent
Uncommon (0.1% to 1%): Urinary retention[Ref]

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity not otherwise specified
Postmarketing reports: Anaphylaxis[Ref]

Immunologic

Common (1% to 10%): Influenza-like symptoms, infection[Ref]

Metabolic

Common (1% to 10%): Weight gain, abnormal alkaline phosphatase, enzyme abnormality[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia, leg pain[Ref]

Nervous system

Common (1% to 10%): Headache, vertigo/dizziness, migraine
Uncommon (0.1% to 1%): Paresthesia, memory impairment
Rare (0.01% to 0.1%): Convulsions[Ref]

Ocular

Common (1% to 10%): Abnormal accommodation, xerophthalmia, vision abnormal[Ref]

Other

Common (1% to 10%): Fatigue, chest pain, malaise, pain, fall[Ref]

Psychiatric

Common (1% to 10%): Somnolence, anxiety
Uncommon (0.1% to 1%): Nervousness
Postmarketing reports: Confusion, disorientation, memory impairment, hallucinations, aggravation of symptoms of dementia (e.g., confusion, disorientation, delusion) after therapy was initiated in patients taking cholinesterase inhibitors for the treatment of dementia[Ref]

Renal

Postmarketing reports: Renal dysfunction[Ref]

Respiratory

Common (1% to 10%): Sinusitis, asthma, bronchitis, coughing, dyspnea[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Detrol (tolterodine)." Pharmacia and Upjohn, Kalamazoo, MI.

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Some side effects of Detrol LA may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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