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Desoxyn Side Effects

Generic name: methamphetamine

Medically reviewed by Last updated on Jan 23, 2023.

Note: This document contains side effect information about methamphetamine. Some dosage forms listed on this page may not apply to the brand name Desoxyn.

Applies to methamphetamine: oral tablet.


Oral route (Tablet)

Methamphetamine has a high potential for abuse. Particular attention should be paid to the possibility of subjects obtaining methamphetamine for non-therapeutic use or distribution to others, and the drug should be prescribed or dispensed sparingly. Misuse of methamphetamine may cause sudden death and serious cardiovascular adverse events.

Serious side effects of Desoxyn

Along with its needed effects, methamphetamine (the active ingredient contained in Desoxyn) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methamphetamine:


  • Agitation
  • false beliefs that cannot be changed by facts
  • seeing, hearing, or feeling things that are not there

Incidence not known

  • Blurred vision
  • chest discomfort or pain
  • dark-colored urine
  • difficulty breathing
  • dizziness
  • faintness
  • false or unusual sense of wellbeing
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • muscle cramps, spasms, pain, or stiffness
  • pounding in the ears
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • swelling of the feet or lower legs
  • trembling or shaking of the hands or feet
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • uncontrolled vocal outbursts and tics
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking methamphetamine:

Symptoms of overdose

  • Aggressive
  • angry
  • confusion
  • dark urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast breathing
  • fast, slow, or irregular heartbeat
  • muscle cramps, spasms, pain, or stiffness
  • nausea
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • seizures
  • stomach cramps
  • sweating
  • tremor
  • unusual tiredness or weakness
  • vomiting

Other side effects of Desoxyn

Some side effects of methamphetamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • constipation
  • decreased interest in sexual intercourse
  • dry mouth
  • hives or welts, itching, or skin rash
  • inability to have or keep an erection
  • indigestion
  • loss in sexual ability, desire, drive, or performance
  • passing of gas
  • redness of the skin
  • weight loss

For Healthcare Professionals

Applies to methamphetamine: oral tablet, oral tablet extended release.


Frequency not reported: Elevated blood pressure, tachycardia, palpitation, fatal cardiorespiratory arrest

Postmarketing reports: Peripheral vasculopathy[Ref]


Frequency not reported: Rhabdomyolysis, growth suppression[Ref]


Rare (less than 0.1%): Psychotic episodes

Frequency not reported: Dysphoria, euphoria, insomnia, restlessness[Ref]

Nervous system

Frequency not reported: Dizziness, overstimulation, tremor, headache, exacerbation of motor/phonic tics and Tourette's syndrome[Ref]


Frequency not reported: Diarrhea, constipation, dry mouth, unpleasant taste, other GI disturbances[Ref]


Frequency not reported: Impotence, libido changes, frequent or prolonged erections[Ref]


Frequency not reported: Urticaria[Ref]

Frequently asked questions


1. "Product Information. Desoxyn (methamphetamine)." Abbott Pharmaceutical (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.