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Daridorexant Side Effects

Medically reviewed by Last updated on Aug 8, 2023.

Applies to daridorexant: oral tablet.

Serious side effects of Daridorexant

Along with its needed effects, daridorexant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking daridorexant:

More common

  • Relaxed and calm
  • sleepiness
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  • unusually deep sleep
  • unusually long duration of sleep

Incidence not known

  • Changes in behavior
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • seeing, hearing, or feeling things that are not there
  • thoughts of killing oneself
  • trouble concentrating

Other side effects of Daridorexant

Some side effects of daridorexant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dizziness
  • feeling of constant movement of self or surroundings
  • headache
  • nausea
  • sensation of spinning

For Healthcare Professionals

Applies to daridorexant: oral tablet.


The most common adverse reactions were headache, somnolence, and fatigue.[Ref]


Nausea includes nausea, vomiting and procedural nausea.[Ref]

Common (1% to 10%): Nausea (up to 3%)[Ref]


Somnolence or fatigue includes somnolence, sedation, fatigue, hypersomnia and lethargy.[Ref]

Common (1% to 10%): Somnolence or fatigue (up to 6%)

Uncommon (0.1% to 1%): Sleep paralysis (up to 0.5%), hypnagogic and hypnopompic hallucinations (0.6%)[Ref]

Nervous system

Common (1% to 10%): Headache (up to 7%), dizziness (up to 3%)[Ref]

Headache includes headache, tension headache, migraine with and without aura and head discomfort.

Dizziness includes, dizziness, vertigo and labyrinthitis.[Ref]

Frequently asked questions


1. Product Information. Quviviq (daridorexant). Idorsia Pharmaceuticals US Inc. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.