Daridorexant Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 27, 2023.

Applies to daridorexant: oral tablet.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.

If your condition does not improve or if they get worse within 7 to 10 days. Tell your doctor right away. Insomnia that lasts longer than this may be a sign of another medical problem.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using this medicine.

This medicine may cause some people, especially older persons, to become drowsy, dizzy, or less alert than they are normally, which may lead to falls, fractures, or other injuries. Even though daridorexant is taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Tell your doctor right away if you start to feel depressed or any unusual thoughts or behaviors that trouble you (including suicidal thoughts), especially if they are new or get worse quickly.

This medicine may cause you to do things while you are still asleep that you may not remember the next morning. You could drive a car, sleepwalk, have sex, make phone calls, or prepare and eat food while you are asleep or not fully awake. Tell your doctor right away if any of these things occur.

This medicine may cause sleep paralysis (temporary inability to move or talk for up to several minutes while you are going to sleep or wake up) or have cataplexy-like symptoms (temporary weakness in your legs). Tell your doctor right away if you have these symptoms while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of daridorexant

Along with its needed effects, daridorexant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking daridorexant:

Other side effects of daridorexant

Some side effects of daridorexant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to daridorexant: oral tablet.

General adverse events

The most common adverse reactions were headache, somnolence, and fatigue.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea^[Ref]

Nausea includes nausea, vomiting and procedural nausea.^[Ref]

Hypersensitivity

Postmarketing: Hypersensitivity, angioedema, rash, urticaria^[Ref]

Nervous system

• Common (1% to 10%): Headache, dizziness^[Ref]

Headache includes headache, tension headache, migraine with and without aura and head discomfort.

Dizziness includes, dizziness, vertigo and labyrinthitis.^[Ref]

Psychiatric

• Common (1% to 10%): Somnolence or fatigue
• Uncommon (0.1% to 1%): Sleep paralysis, hypnagogic and hypnopompic hallucinations

Postmarketing: Nightmares, abnormal dreams^[Ref]

Somnolence or fatigue includes somnolence, sedation, fatigue, hypersomnia and lethargy.^[Ref]

See also:

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Further information

Daridorexant side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer