Dalfampridine Side Effects
Medically reviewed by Drugs.com. Last updated on Feb 27, 2025.
Applies to dalfampridine: oral tablet extended release.
Precautions
It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
Check with your doctor right away if you have seizures while taking this medicine.
Do not take dalfampridine together with other aminopyridine medicines (eg, compounded 4-AP, fampridine). Taking these medicines together will increase the chance for more serious side effects.
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.
This medicine may make you dizzy, lightheaded, or feel a constant movement of self or surroundings. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of dalfampridine
Along with its needed effects, dalfampridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:
More common side effects
- bladder pain
- bloody or cloudy urine
- difficult, burning, or painful urination
- frequent urge to urinate
- lower back or side pain
Less common side effects
- blurred vision
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- difficulty controlling your bladder or bowels
- feeling sad or depressed
- forgetful
- muscle cramps
- problems with swallowing
- slurred speech
- unusual tiredness or weakness
Incidence not known
- chest tightness
- cough
- dizziness or lightheadedness
- fast heartbeat
- feeling of constant movement of self or surroundings
- hives, itching, skin rash
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- sensation of spinning
- vomiting
Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:
Symptoms of overdose
- confusion
- increased sweating
- memory loss
- reduced awareness
- seizures
- weakness
Other side effects of dalfampridine
Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
Less common side effects
- back pain
- constipation
- fever
- muscle aches
- sore throat
- stomach discomfort, upset, or pain
- stuffy or runny nose
For healthcare professionals
Applies to dalfampridine: oral tablet extended release.
Nervous system adverse events
- Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor
- Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia[Ref]
Gastrointestinal
Musculoskeletal
- Common (1% to 10%): Back pain[Ref]
Respiratory
Genitourinary
- Very common (10% or more): Urinary tract infection (12%)[Ref]
Hypersensitivity
- Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity[Ref]
Psychiatric
Other
- Common (1% to 10%): Asthenia
- Uncommon (0.1% to 1%): Chest discomfort[Ref]
Cardiovascular
- Common (1% to 10%): Palpitations[Ref]
Dermatologic
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References
1. (2010) "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics
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Further information
Dalfampridine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.