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Dalfampridine Side Effects

In Summary

Commonly reported side effects of dalfampridine include: urinary tract infection. Other side effects include: equilibrium disturbance, insomnia, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dalfampridine: oral tablet extended release

Along with its needed effects, dalfampridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
Less common
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficulty controlling your bladder or bowels
  • difficulty walking
  • feeling sad or depressed
  • forgetful
  • muscle cramps
  • problems with swallowing
  • slurred speech
  • unusual tiredness or weakness
Incidence not known

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose
  • Confusion
  • epileptic seizure that will not stop
  • increased sweating
  • memory loss
  • reduced awareness
  • seizures
  • weakness

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Less common

For Healthcare Professionals

Applies to dalfampridine: oral tablet extended release

Nervous system

Common (1% to 10%): Dizziness, headache, balance disorder, multiple sclerosis relapse, paresthesia, tremor
Uncommon (0.1% to 1%): Seizure, exacerbation of trigeminal neuralgia[Ref]


Common (1% to 10%): Nausea, constipation, dyspepsia
Postmarketing reports: Vomiting[Ref]


Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Nasopharyngitis, pharyngolaryngeal pain, dyspnea[Ref]


Very common (10% or more): Urinary tract infection (12%)[Ref]


Uncommon (0.1% to 1%): Anaphylaxis, angioedema, hypersensitivity[Ref]


Common (1% to 10%): Insomnia, anxiety[Ref]


Common (1% to 10%): Asthenia
Uncommon (0.1% to 1%): Chest discomfort[Ref]


Common (1% to 10%): Palpitations[Ref]


Uncommon (0.1% to 1%): Rash, urticaria[Ref]


1. "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics, Hawthorne, NY.

Some side effects of dalfampridine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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