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Dalfampridine Side Effects

For the Consumer

Applies to dalfampridine: oral tablet extended release

Along with its needed effects, dalfampridine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalfampridine:

More common
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
Less common
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficulty controlling your bladder or bowels
  • difficulty walking
  • feeling sad or depressed
  • forgetful
  • muscle cramps
  • numbness or tingling in your arms, legs, or face
  • slurred speech or problems with swallowing
  • unusual tiredness or weakness
Incidence not known
  • Cough
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest

Get emergency help immediately if any of the following symptoms of overdose occur while taking dalfampridine:

Symptoms of overdose
  • Confusion
  • epileptic seizure that will not stop
  • increased sweating
  • memory loss
  • problems with memory
  • reduced awareness
  • seizures
  • weakness

Some side effects of dalfampridine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Headache
  • lack or loss of strength
  • nausea
  • trouble sleeping
Less common
  • Back pain
  • constipation
  • fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose

For Healthcare Professionals

Applies to dalfampridine: oral tablet extended release


Renal side effects including urinary tract infection (12%) have been reported.[Ref]


General side effects including insomnia (9%) and asthenia (7%) have been reported.[Ref]

Nervous system

Nervous system side effects including dizziness (7%), headache (7%), balance disorder (5%), multiple sclerosis relapse (4%), and paresthesia (4%) have been reported.[Ref]


Gastrointestinal side effects including nausea (7%), constipation (3%), dyspepsia (2%), and pharyngolaryngeal pain (2%) have been reported.[Ref]


Musculoskeletal side effects including back pain (5%) have been reported.[Ref]


Respiratory side effects including nasopharyngitis (4%) have been reported.[Ref]


Genitourinary side effects have been have reported in animal studies which noted a significant increase in uterine polyps at the highest dose tested.[Ref]


1. "Product Information. Ampyra (dalfampridine)." Acorda Therapeutics, Hawthorne, NY.

Some side effects of dalfampridine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.