Dalfampridine Dosage

Medically reviewed by Drugs.com. Last updated on Sep 12, 2023.

Usual Adult Dose for Multiple Sclerosis

Maximum dose: 10 mg orally every 12 hours

Comments:

• This drug may be taken with or without food.
• Tablets should be swallowed whole, and not divided, crushed, chewed, or dissolved.
• Patients should not take double or extra doses if a dose is missed.

Use: To improve walking in adult patients with multiple sclerosis (MS) demonstrated by an increase in walking speed

Renal Dose Adjustments

• Mild renal impairment (CrCl 51 to 80 mL/min): Plasma levels of this drug may approach those seen at a dose of 15 mg 2 times a day, a dose that is 1.5 times the maximum recommended dose and may be associated with an increased risk of seizures; because renal impairment is common after age 50, estimating CrCl is particularly important in these patients
• Moderate to severe renal impairment (CrCl less than 51 mL/min): Contraindicated

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component, 4-aminopyridine, or any of the ingredients
• History of seizure
• Moderate or severe renal impairment (CrCl 50 mL/min or less)

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug may be taken with or without food.
• Tablets should be swallowed whole, and not divided, crushed, chewed, or dissolved.

Patient advice:

• Do not take double or extra doses if a dose is missed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer