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Dalfampridine Dosage

Medically reviewed on November 13, 2017.

Applies to the following strengths: 10 mg

Usual Adult Dose for Multiple Sclerosis

Maximum dose: 10 mg orally every 12 hours

Comments:
-This drug may be taken with or without food.
-Tablets should be swallowed whole, and not divided, crushed, chewed, or dissolved.
-Patients should not take double or extra doses if a dose is missed.

Use: To improve walking in adult patients with multiple sclerosis (MS) demonstrated by an increase in walking speed

Renal Dose Adjustments

-Mild renal impairment (CrCl 51 to 80 mL/min): Plasma levels of this drug may approach those seen at a dose of 15 mg 2 times a day, a dose that is 1.5 times the maximum recommended dose and may be associated with an increased risk of seizures; because renal impairment is common after age 50, estimating CrCl is particularly important in these patients
-Moderate to severe renal impairment (CrCl less than 51 mL/min): Contraindicated

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to the active component, 4-aminopyridine, or any of the ingredients
-History of seizure
-Moderate or severe renal impairment (CrCl 50 mL/min or less)

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-This drug may be taken with or without food.
-Tablets should be swallowed whole, and not divided, crushed, chewed, or dissolved.

Patient advice:
-Do not take double or extra doses if a dose is missed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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