Dalbavancin Side Effects

For the Consumer

Applies to dalbavancin: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by dalbavancin. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dalbavancin:

• Abdominal or stomach pain or tenderness
• back pain
• black, tarry stools
• bleeding gums
• blood in the urine or stools
• chest pain or tightness
• chills
• clay colored stools
• cough
• dark urine
• decreased appetite
• difficulty swallowing
• dizziness
• fast heartbeat
• feeling of warmth
• fever
• headache
• hives, welts, itching, or rash
• loss of appetite
• painful or difficult urination
• pale skin
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• redness of the face, neck, arms, and occasionally, upper chest
• redness of the skin
• severe abdominal or stomach cramps and pain
• sore mouth or tongue
• sore throat
• sores, ulcers, or white spots on the lips or in the mouth
• swelling of the feet or lower legs
• swollen glands
• tightness in the chest
• troubled breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting of blood or material that looks like coffee grounds
• watery and severe diarrhea, which may also be bloody
• yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with dalbavancin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

• Diarrhea

• Anxiety
• blurred vision
• cold sweats
• coma
• confusion
• cool, pale skin
• depression
• increased hunger
• nightmares
• seizures
• shakiness
• slurred speech

For Healthcare Professionals

Applies to dalbavancin: intravenous powder for injection

General

The most common adverse reactions were nausea, headache, and diarrhea.^[Ref]

Cardiovascular

Frequency not reported: Anemia, hemorrhagic anemia, leucopenia, neutropenia, thrombocytopenia, petechiae, eosinophilia, thrombocytosis, international normalized ratio increased, phlebitis, wound hemorrhage, spontaneous hematoma^[Ref]

Dermatologic

Common (1% to 10%): Rash, pruritus
Frequency not reported: Urticaria, flushing^[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, vomiting
Frequency not reported: Gastrointestinal hemorrhage, melena, hematochezia, abdominal pain^[Ref]

Hepatic

Frequency not reported: Hepatotoxicity, hepatic transaminases increased, blood alkaline phosphatase increased^[Ref]

Hypersensitivity

Frequency not reported: Anaphylactoid reaction^[Ref]

Immunologic

Frequency not reported: Clostridium difficile colitis, oral candidiasis, vulvovaginal mycotic infection^[Ref]

Local

Frequency not reported: Infusion-related reactions^[Ref]

Metabolic

Frequency not reported: Hypoglycemia^[Ref]

Nervous system

Common (1% to 10%): Headache
Frequency not reported: Dizziness^[Ref]

Respiratory

Frequency not reported: Bronchospasm^[Ref]

Not all side effects for dalbavancin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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