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Cyclizine Side Effects

For the Consumer

Applies to cyclizine: oral tablet, oral tablet chewable

Get emergency medical help if you have any of these signs of an allergic reaction while taking cyclizine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using cyclizine and call your doctor at once if you have:

  • painful or difficult urination;

  • little or no urinating;

  • pounding heartbeats or fluttering in your chest; or

  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • drowsiness, weakness, loss of coordination;

  • nausea, dry mouth, constipation; or

  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to cyclizine: oral tablet, oral tablet chewable

Nervous system

Paralysis was reported with IV formulations and typically affected the limbs within minutes of administration. This side effect usually resolved within hours following discontinuation of treatment.[Ref]

Rare (0.01% to 0.1%): Depressed levels of consciousness, loss of consciousness

Frequency not reported: Convulsions, coordination abnormal, decreased consciousness, dizziness, drowsiness, dyskinesia, dystonia, extrapyramidal motor disturbances, generalized chorea, headaches, incoordination, paralysis, paresthesia, somnolence, transient speech disorders, tremor[Ref]


Rare (0.01% to 0.1%): Chills, sensation of heaviness

Frequency not reported: Asthenia, pain, tinnitus[Ref]


Rare (0.01% to 0.1%): Pruritus

Frequency not reported: Allergic skin reaction, blisters, drug rash, erythema, fixed drug eruption, photosensitivity reaction, urticaria[Ref]


Frequency not reported: Abdominal pain upper, constipation, diarrhea, dry mouth, duodenogastric reflux, increased gastric reflux, nausea, stomach pain, vomiting[Ref]


Frequency not reported: Agitation, auditory and visual hallucinations, disorientation, euphoria, insomnia, nervousness, Restlessness[Ref]

Auditory and visual hallucinations were reported, especially at doses exceeding recommendations.[Ref]


Frequency not reported: Arrhythmias, hypertension, hypotension, palpitations, tachycardia, thrombophlebitis, vein tracking[Ref]


Frequency not reported: Apnea, bronchospasm, dry nose, dry throat[Ref]


Frequency not reported: Cholestatic hepatitis, cholestatic jaundice, hypersensitivity hepatitis, liver dysfunction[Ref]


Frequency not reported: Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia[Ref]


Injection site reactions included blisters, erythema, pain, thrombophlebitis, and vein tracking.[Ref]

Frequency not reported: Injection site erythema, injection site pain, injection site reactions[Ref]


Anaphylaxis occurred with concomitant propanidid given via IV administration in the same syringe.[Ref]

Frequency not reported: Anaphylaxis, angioedema, hypersensitivity reactions[Ref]


Frequency not reported: Decreased appetite, loss of appetite[Ref]


Frequency not reported: Muscle spasms, twitching[Ref]


Frequency not reported: Blurred vision, oculogyric crisis[Ref]


Frequency not reported: Urinary retention[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Bonine For Kids (cyclizine)." Heritage/Insight Consumer Products, Plymouth, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.