Cyclizine Side Effects

Applies to cyclizine: oral tablet, oral tablet chewable.

Get emergency medical help if you have any of these signs of an allergic reaction while taking cyclizine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using cyclizine and call your doctor at once if you have:

• painful or difficult urination;

• little or no urinating;

• pounding heartbeats or fluttering in your chest; or

• a light-headed feeling, like you might pass out.

Common side effects may include:

• drowsiness, weakness, loss of coordination;

• nausea, dry mouth, constipation; or

• blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:

For healthcare professionals

Applies to cyclizine: oral tablet, oral tablet chewable.

Nervous system adverse events

• Rare (0.01% to 0.1%): Depressed levels of consciousness, loss of consciousness
• Frequency not reported: Convulsions, coordination abnormal, decreased consciousness, dizziness, drowsiness, dyskinesia, dystonia, extrapyramidal motor disturbances, generalized chorea, headaches, incoordination, paralysis, paresthesia, somnolence, transient speech disorders, tremor^[Ref]

Paralysis was reported with IV formulations and typically affected the limbs within minutes of administration. This side effect usually resolved within hours following discontinuation of treatment.^[Ref]

Other

• Rare (0.01% to 0.1%): Chills, sensation of heaviness
• Frequency not reported: Asthenia, pain, tinnitus^[Ref]

Dermatologic

• Rare (0.01% to 0.1%): Pruritus
• Frequency not reported: Allergic skin reaction, blisters, drug rash, erythema, fixed drug eruption, photosensitivity reaction, urticaria^[Ref]

Gastrointestinal

• Frequency not reported: Abdominal pain upper, constipation, diarrhea, dry mouth, duodenogastric reflux, increased gastric reflux, nausea, stomach pain, vomiting^[Ref]

Psychiatric

• Frequency not reported: Agitation, auditory and visual hallucinations, disorientation, euphoria, insomnia, nervousness, Restlessness^[Ref]

Auditory and visual hallucinations were reported, especially at doses exceeding recommendations.^[Ref]

Cardiovascular

• Frequency not reported: Arrhythmias, hypertension, hypotension, palpitations, tachycardia, thrombophlebitis, vein tracking^[Ref]

Respiratory

• Frequency not reported: Apnea, bronchospasm, dry nose, dry throat^[Ref]

Hepatic

• Frequency not reported: Cholestatic hepatitis, cholestatic jaundice, hypersensitivity hepatitis, liver dysfunction^[Ref]

Hematologic

• Frequency not reported: Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia^[Ref]

Local

• Frequency not reported: Injection site erythema, injection site pain, injection site reactions^[Ref]

Injection site reactions included blisters, erythema, pain, thrombophlebitis, and vein tracking.^[Ref]

Hypersensitivity

• Frequency not reported: Anaphylaxis, angioedema, hypersensitivity reactions^[Ref]

Anaphylaxis occurred with concomitant propanidid given via IV administration in the same syringe.^[Ref]

Metabolic

• Frequency not reported: Decreased appetite, loss of appetite^[Ref]

Musculoskeletal

• Frequency not reported: Muscle spasms, twitching^[Ref]

Ocular

• Frequency not reported: Blurred vision, oculogyric crisis^[Ref]

Genitourinary

• Frequency not reported: Urinary retention^[Ref]

Further information

Cyclizine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer