Cophene B Side Effects
Generic name: brompheniramine
Note: This document contains side effect information about brompheniramine. Some of the dosage forms listed on this page may not apply to the brand name Cophene B.
For the Consumer
Applies to brompheniramine: oral liquid
Ask a doctor or pharmacist before using this medicine if you have health problems or use other medications, or if you are pregnant or breastfeeding.
Do not use cold or allergy medicine to make a child sleepy.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using brompheniramine (the active ingredient contained in Cophene B) and call your doctor at once if you have:
feeling nervous, restless, or dizzy;
a seizure; or
little or no urination.
Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.
Common side effects may include:
flushing (warmth, redness, or tingly feeling);
dry mouth, nose, or throat; or
feeling restless or excited (especially in a child).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to brompheniramine: compounding powder, injectable solution, oral capsule, oral capsule extended release, oral liquid, oral suspension extended release, oral tablet, oral tablet chewable extended release, oral tablet extended release
Nervous system side effects have included central nervous system (CNS) depression, resulting in drowsiness and sedation in nearly 50% of patients treated. This effect has often been transient and ceased with continued use. Motor skills have be impaired and patients should be advised to avoid tasks which require attention. Patients should also avoid concomitant use with alcohol and other sedative-hypnotic drugs. Dyskinesias have rarely been reported following chronic use of brompheniramine (the active ingredient contained in Cophene B) [Ref]
A few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of brompheniramine extended over a period of up to 10 years. Some of these cases were only partially relieved by discontinuation of the drug. Haloperidol was successful in relieving symptoms in these patients. Spasmodic torticollis has been reported in a child given brompheniramine over an eight month period.[Ref]
Ocular side effects have included blurred vision, diplopia, and dry eyes due to anticholinergic effects.[Ref]
More about Cophene B (brompheniramine)
- Other brands
Related treatment guides
1. Blamoutier J "Comparative trial of two antihistamines, mequitazine and brompheniramine." Curr Med Res Opin 5 (1978): 366-70
2. Schuller DE, Turkewitz D "Adverse effects of antihistamines." Postgrad Med 79 (1986): 75-86
3. Thach BT, Chase TN, Bosma JF "Oral facial dyskinesia associated with prolonged use of antihistaminic decongestants." N Engl J Med 293 (1975): 486-7
4. Lewith GT, Davidson F "Dystonic reactions to Dimotapp elixir." J R Coll Gen Pract 31 (1981): 241
5. Simons FE, Frith EM, Simons KJ "The pharmacokinetics and antihistaminic effects of brompheniramine." J Allergy Clin Immunol 70 (1982): 458-64
Some side effects may not be reported. You may report them to the FDA.