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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Elixir, Rynex DM, Robitussin Allergy & Cough, Dimetapp Children's Cold & Cough, Lodrane D, ENT, LoHist-12, Show all 283 »Dimetapp Children's Cold & Allergy, Cold & Cough Childrens, Trexbrom, Dimetane Extentab, Bromax, Dime Time Extended Release, J-Tan PD, Lodrane 12 Hour, Brovex, LoHist-12D, Tussi-Pres B, Dimetapp DM, J-Tan, Alahist DM, Brotapp, Endafed, Bromadine-DM, Brometane DX, Bromatane DX, Q-Tapp DM, Presgen B, BroveX ADT, Brofed, Rhinabid, Seradex, Brovex CT, Dimetapp Allergy, Siltane, Lohist-DM, M-END, Staflex, VaZol, Centussin DHC, Lodrane 24, BroveX PEB, Zotex-PE, Ru-Hist D, Vazotab, Dimaphen Elixir, J-Tan D, VaZol-D, Alacol, BroveX PB, VazoBid, Entre-B, Rynex PE, BroveX-D, LoHist PEB, Relhist BP, Dimetane Decongestant, Bromfenex PE, Canges-HC NR, BPM PE HC, FluTuss HC, VazoTuss HC, Drocon-CS, Canges-HC, VasoTuss HC, Tusnel-HC, Poly-Tussin DHC, Sildec DM, EndaCof-DH, J-Cof DHC, Ala-Hist D, Ala-Hist, Anaplex HD, Bromplex HD, Bromfed-PD Capsules, Bromfenex PE Pediatric, Rhinabid PD, BPM PE, Bromaphedrine D, B-Vex D, V-HIST, J-Tan D HC, Visvex, Bromph HD, Bromcomp HC, Endacof HC, SymTan A, Brovex HC, Alenaze-D NR, Altatapp, Iofed, Ultrabrom, Pseubrom, Lodrane Liquid, Touro Allergy, Nalfed, M-Hist TD, Histex SR, Iofed PD, Respahist, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Bromfenex, Andehist NR Syrup, Bromaline, Brovex SR, Bromhist-NR, Dimaphen, Lodrane 24D, J-TanD PD, LoHist-PD, Di-Bromm, Unit-Hist Drops, Sildec, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Nalfed PD, Lodrane LD, Seradex-LA, Tanabid SR, Vazobid-PD, Dibrom, Myphetapp, Carbodex DM Syrup, Brotapp PE, RespaHist II, J-Tan D SR, Phenyl 15/12mg, Brom Tann PE, Brohist D, Decon-A, Alenaze-D, Lodrane, LoHist PSB, Bromhist Pediatric, B-Vex PD, Touro A&H, Shellcap, Shellcap PD, Allent, BroveX PSB, BroveX PD, Bromfed SR, Bromfed PD, Bidhist-D, Lodrane 12D, BroveX PSE, Rynex PSE, Phenyl 7.5/6mg, Bromtapp-DM, Rydex, Mar-cof BP, Mesehist WC, AccuHist PDX Syrup, Allanhist PDX Syrup, Uni-Hist PDX Syrup, M-End WC, Polytine CS, Myphetane DC, Dimetane DC, Poly-Histine CS, Trihist-CS, Poly CS, Liquihistine CS, EndaCof-PD, Bromhist-PDX, Duravent DPB, BPM DM PHEN, Alacol DM, BP Allergy DM, TL-Hist DM, Y-COF DMX, BroveX PB DM, Niva-Hist DM, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup, M-End PE, Poly-Tussin AC, Cophene B, Codimal A, B-Vex, Nasahist B, Respa BR, ND-Stat, Histaject, Veltane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, Bromaphen, Prop-A-Tane, Tanacof-XR, Bidhist, Lodrane XR, BroveX CBX, BroveX CB, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, Nalex AC, SymPak II, V-COF, Trexbrom (old formulation), BetaTan, Vazotan, Dicel CD, Pulmari, Tusdec-DM, Bromtuss DM, Myphetane DX Cough, Bromanate DX Cough, Bromophed-DX, Liquiphed DM, Bromphenex DM, Anaplex DM, Myphetane DX, Dimetane DX, Anaplex DMX, BroveX PSB DM, BromTann/DM Tann/PSE Tann, Bromdex D, Dallergy DM, Neo DM Syrup, Brotapp-DM, Andehist DM NR Syrup, Uni-Hist PDX Drops, Bromph DM, Allanhist PDX Drops, Histacol BD Drops, ProHist DM, Brom Tann, Pediahist DM Drops, Bromhist-DM Drops, PSE Brom DM, Bromaxefed DM RF Syrup, Bromaline DM, Carbofed DM Syrup, Bromplex DM, Uni-Hist DM Pediatric Drops, PBM Allergy, BroveX PSE DM, EndaCof-DM, DuraTan DM, AP-Hist DM, Histinex DM, Poly DM, Prohistine DM, Bromatan-DM, Brotapp PE-DM, Dimaphen DM, Dur-Tann DM, BroveX PEB DM, BPM PE DM, Balacall DM, LoHist PEB DM, Highland DM, Delhistine DM, Durahistine DM, DM Cold and Cough, EndaCof PD Drops, AccuHist DM Pediatric Drops, BroveX PSE DM Tablets, PediaHist DM, Poly Histine DM, Trihist DM, Iohist DM, Polytine DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, P-Hist DM Drops

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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