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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Cough, Resperal-DM, Bromphenex DM, Lodrane, Dimetapp Children's Cold & Allergy, Dimetapp Elixir, Dimaphen, Rynex DM, Show all 287 »Robitussin Allergy & Cough, Dimetapp DM, Cophene B, Bromaline, Dimaphen DM, M-End PE, Decon-A, Bromadine-DM, Brovex, Brofed, ENT, Histacol DM Pediatric Syrup, Sildec, Nalex AC, Bromfed PD, Myphetane DX Cough, Dimetane DX, Poly-Tussin AC, AccuHist DM Pediatric Drops, Brotapp, Tanacof-XR, BPM DM PHEN, Cold & Cough Childrens, EndaCof-DM, Veltane, Dimetapp Allergy, Dimetane Extentab, Respa BR, Relhist BP, Dimetane Decongestant, J-Tan D, BroveX-D, LoHist PEB, Bromaphedrine D, Rynex PE, B-Vex D, Alacol, BroveX PB, VazoBid, Dimaphen Elixir, VaZol-D, Alenaze-D NR, Rhinabid PD, BPM PE, Entre-B, Staflex, Bromfed-PD Capsules, FluTuss HC, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Centussin DHC, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist, Ala-Hist D, Tusnel-HC, VasoTuss HC, BPM PE HC, Canges-HC NR, VazoTuss HC, Bromfenex PE Pediatric, Endacof HC, Bromfenex PE, Rhinabid, BroveX ADT, J-Tan D HC, SymTan A, Brovex HC, Bromcomp HC, Canges-HC, Visvex, Bromph HD, Bromplex HD, Anaplex HD, Drocon-CS, M-END, Vazotab, Seradex-LA, BroveX PEB, Lodrane Liquid, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Nalfed, Allent, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, Lodrane 24D, LoHist-PD, LoHist-12D, Shellcap PD, Shellcap, Ru-Hist D, Dime Time Extended Release, Zotex-PE, V-HIST, Phenyl 7.5/6mg, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Brohist D, Alenaze-D, RespaHist II, Brotapp PE, Tanabid SR, Histacol BD Drops, Vazobid-PD, Dibrom, Touro A&H, Altatapp, Myphetapp, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Brom Tann, Andehist DM NR Syrup, Allanhist PDX Drops, AccuHist PDX Syrup, BroveX PB CX, TL-Hist CD, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, Polytine CS, M-End WC, Mar-cof BP, Rydex, Mesehist WC, Uni-Hist PDX Syrup, EndaCof-AC, Allanhist PDX Syrup, EndaCof-PD, Bromhist-PDX, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Niva-Hist DM, Alahist DM (old formulation), BroveX PB DM, Duravent DPB, Alacol DM, BroveX PB C, BroveX CBX, Presgen B, J-Tan, Dristan Cold Maximum Strength, P-Tex, Bromaphen, J-Tan PD, Bromax, Prop-A-Tane, Histaject, Codimal A, B-Vex, LoHist-12, VaZol, Lodrane 12 Hour, Lodrane 24, Brovex CT, BroveX CB, Nasahist B, ND-Stat, Siltane, Bidhist, Lodrane XR, Trexbrom (old formulation), V-COF, BetaTan, Vazotan, Pulmari, Seradex, Trexbrom, Dicel CD, SymPak II, BP Allergy DM, Y-COF DMX, Uni-Hist PDX Drops, Liquiphed DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Bromophed-DX, Brometane DX, EndaCof PD Drops, Anaplex DM, Brotapp-DM, Comtrex Acute Head Cold, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, PediaHist DM, Durahistine DM, TL-Hist DM, DuraTan DM, Tusdec-DM, Bromtuss DM, Dur-Tann DM, Tussi-Pres B, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Balacall DM, Brotapp PE-DM, Lohist-DM, Glenmax PEB DM, Bromatan-DM, Glenmax PEB DM Forte, AP-Hist DM, DM Cold and Cough, M-Hist DM, Relcof DM, Histinex DM, Prohistine DM, Poly DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Poly Histine DM, J-TanD PD

Medically reviewed by Drugs.com. Last updated on Aug 19, 2018.

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Breast Feeding

Lactation

Antihistamines

Administrative Information

LactMed Record Number

34

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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