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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Rynex DM, Dimetapp Elixir, Brovex, Dimetapp Children's Cold & Cough, LoHist-12, Lodrane D, Bromax, Show all 283 »Robitussin Allergy & Cough, Dime Time Extended Release, Alahist DM, Dimetane Extentab, J-Tan PD, Lodrane, Dimetapp DM, Trexbrom, Brofed, Cold & Cough Childrens, Seradex, LoHist-12D, Lodrane 12 Hour, Siltane, J-Tan, Brotapp, Lodrane 24, Duravent DPB, Endafed, Tussi-Pres B, Bromhist Pediatric, Presgen B, Bromaline, Bromaline DM, Q-Tapp DM, Dimetapp Children's Cold & Allergy, Bromadine-DM, Bromatane DX, Q-Tapp, AccuHist PDX Syrup, Sildec, Staflex, VaZol, Brovex CT, BroveX ADT, Dimetapp Allergy, DM Cold and Cough, M-END, Rhinabid, Lohist-DM, Dimetane DX, Bromhist-DM, Vazotab, BroveX PEB, Ru-Hist D, Dimetane Decongestant, Relhist BP, Alacol, BroveX PB, Entre-B, Rynex PE, BroveX-D, LoHist PEB, J-Tan D, B-Vex D, VazoTuss HC, FluTuss HC, Canges-HC NR, Canges-HC, Drocon-CS, Bromplex HD, Anaplex HD, BPM PE HC, VasoTuss HC, EndaCof-DH, Poly-Tussin DHC, J-Cof DHC, Ala-Hist, Tusnel-HC, Ala-Hist D, Bromph HD, Visvex, Zotex-PE, BPM PE, Rhinabid PD, Bromaphedrine D, Alenaze-D NR, Dimaphen Elixir, VaZol-D, Bromfed-PD Capsules, Bromfenex PE Pediatric, Endacof HC, Bromcomp HC, Brovex HC, SymTan A, Bromfenex PE, J-Tan D HC, VazoBid, Myphetapp, M-Hist TD, Histex SR, Ultrabrom, Iofed, Lodrane Liquid, Pseubrom, Bromfenex PD, Bromfenex, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Pseubrom-PD, Ultrabrom PD, Nalfed, Touro Allergy, Brovex SR, Bromhist-NR, Dimaphen, Lodrane 24D, J-TanD PD, LoHist-PD, Di-Bromm, Unit-Hist Drops, Bromaxefed RF Syrup, Andehist NR Syrup, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Shellcap PD, Allent, Brotapp PE, RespaHist II, Tanabid SR, Seradex-LA, Dibrom, Vazobid-PD, Decon-A, Alenaze-D, Phenyl 15/12mg, Phenyl 7.5/6mg, J-Tan D SR, Brom Tann PE, Brohist D, ENT, Altatapp, BroveX PD, BroveX PSE, BroveX PSB, B-Vex PD, Shellcap, Touro A&H, Rynex PSE, Lodrane 12D, LoHist PSB, Centussin DHC, Bromfed PD, Bromfed SR, Bidhist-D, V-HIST, Andehist DM NR Syrup, Mar-cof BP, M-End WC, Rydex, Mesehist WC, Allanhist PDX Syrup, Uni-Hist PDX Syrup, Polytine CS, Poly CS, Dimetane DC, M-End PE, Myphetane DC, Poly-Histine CS, Liquihistine CS, Trihist-CS, EndaCof-PD, Bromhist-PDX, Alacol DM, BPM DM PHEN, BP Allergy DM, Y-COF DMX, Tusdec-DM, TL-Hist DM, BroveX PB DM, Niva-Hist DM, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Poly-Tussin AC, TL-Hist CD, Cophene B, Codimal A, B-Vex, Nasahist B, Respa BR, ND-Stat, Histaject, Veltane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, Bromaphen, Prop-A-Tane, Tanacof-XR, Bidhist, Lodrane XR, BroveX CB, Nalex AC, BroveX CBX, EndaCof-AC, BroveX PB CX, BroveX PB C, SymPak II, Dicel CD, V-COF, Trexbrom (old formulation), BetaTan, Vazotan, Pulmari, Bromtuss DM, Dur-Tann DM, Brometane DX, Liquiphed DM, Anaplex DM, Bromphenex DM, Bromtapp-DM, Brotapp-DM, Bromophed-DX, Myphetane DX Cough, Bromdex D, BromTann/DM Tann/PSE Tann, Neo DM Syrup, Dallergy DM, Bromanate DX Cough, Myphetane DX, Bromaxefed DM RF Syrup, PSE Brom DM, Histacol BD Drops, Allanhist PDX Drops, Brom Tann, ProHist DM, Carbodex DM Syrup, P-Hist DM Drops, Uni-Hist PDX Drops, Bromph DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Anaplex DMX, BroveX PSB DM, AP-Hist DM, EndaCof-DM, Histinex DM, Prohistine DM, Highland DM, Poly DM, DuraTan DM, Bromatan-DM, BroveX PEB DM, Dimaphen DM, BPM PE DM, LoHist PEB DM, Brotapp PE-DM, Balacall DM, Delhistine DM, Polytine DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, PediaHist DM, BroveX PSE DM Tablets, PBM Allergy, BroveX PSE DM, Durahistine DM, Poly Histine DM, KG Hist DM, Iohist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Sildec DM

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine

References

1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

Substance Name

Brompheniramine

CAS Registry Number

86-22-6

Drug Class

Antihistamines

Administrative Information

LactMed Record Number

34

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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