Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, DM Cold and Cough, Robitussin Allergy & Cough, Bromphenex DM, Dimetapp Elixir, Dimetapp Children's Cold & Allergy, Dimetapp Children's Cold & Cough, Rynex DM, Show all 287 »Bromfed PD, Bromaline, Cophene B, M-End PE, Bromaphen, Nalex AC, Alenaze-D NR, Rynex PE, Vazotab, Phenyl 15/12mg, Sildec, Brofed, Bromplex DM, Brotapp-DM, BPM DM PHEN, AccuHist DM Pediatric Drops, Lodrane D, Allanhist PDX Syrup, Bromhist-PDX, Lodrane 24D, Dimaphen, Brotapp, BromTann/DM Tann/PSE Tann, EndaCof-DM, Dimaphen DM, Dimetapp Allergy, Cold & Cough Childrens, Lodrane XR, Respa BR, Dimetane Extentab, J-Tan, Brovex, Bromax, V-COF, Seradex, Bromfenex, Ala-Hist, LoHist PEB, Dimetane Decongestant, J-Tan D, BroveX-D, Entre-B, Relhist BP, Alacol, BroveX PB, VazoBid, Dimaphen Elixir, VaZol-D, Bromaphedrine D, B-Vex D, BPM PE, Rhinabid PD, Bromfed-PD Capsules, Staflex, Rhinabid, Bromfenex PE Pediatric, VazoTuss HC, Carbodex DM Syrup, Sildec DM, Centussin DHC, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist D, Tusnel-HC, VasoTuss HC, BPM PE HC, Canges-HC NR, FluTuss HC, Canges-HC, Bromfenex PE, M-END, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, BroveX PEB, BroveX ADT, Dibrom, Ru-Hist D, Lodrane Liquid, Shellcap PD, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Nalfed, Shellcap, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, LoHist-PD, LoHist-12D, Allent, Touro A&H, Zotex-PE, ProHist DM, V-HIST, Phenyl 7.5/6mg, J-Tan D SR, Brom Tann PE, Brohist D, Alenaze-D, Decon-A, RespaHist II, Brotapp PE, Tanabid SR, Seradex-LA, Vazobid-PD, Dime Time Extended Release, ENT, Endafed, Altatapp, Myphetapp, Lodrane, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, P-Hist DM Drops, Anaplex DM, Brom Tann, EndaCof-PD, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, Polytine CS, M-End WC, Mar-cof BP, Rydex, Mesehist WC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, Acutuss DM Pediatric, TL-Hist CD, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Niva-Hist DM, Alahist DM (old formulation), BroveX PB DM, Duravent DPB, Alacol DM, BP Allergy DM, Presgen B, Y-COF DMX, Poly-Tussin AC, BroveX PB CX, Tusdec-DM, Brovex CT, Dristan Cold Maximum Strength, P-Tex, J-Tan PD, Tanacof-XR, Prop-A-Tane, Veltane, Histaject, Codimal A, B-Vex, LoHist-12, VaZol, Lodrane 12 Hour, Lodrane 24, Nasahist B, BroveX PB C, ND-Stat, Siltane, Bidhist, Trexbrom (old formulation), BetaTan, Vazotan, Pulmari, Trexbrom, Dicel CD, SymPak II, BroveX CB, BroveX CBX, EndaCof-AC, TL-Hist DM, Bromtuss DM, Histacol BD Drops, Bromadine-DM, BroveX PSB DM, Anaplex DMX, Bromdex D, Neo DM Syrup, Dallergy DM, Dimetane DX, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Brometane DX, Comtrex Acute Head Cold, BroveX PSE DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, PBM Allergy, BroveX PSE DM Tablets, Dur-Tann DM, Relcof DM, Tussi-Pres B, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Balacall DM, Brotapp PE-DM, Lohist-DM, Glenmax PEB DM, Bromatan-DM, Glenmax PEB DM Forte, DuraTan DM, AP-Hist DM, M-Hist DM, Histinex DM, PediaHist DM, Prohistine DM, Poly DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Poly Histine DM, Durahistine DM, Dimetapp DM, EndaCof PD Drops, J-TanD PD
Medically reviewed on Jul 22, 2018
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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- Drug class: antihistamines