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Brompheniramine use while Breastfeeding

Medically reviewed by Last updated on Dec 8, 2023.

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Allergy, Dimetapp Children's Cold & Cough, Resperal-DM, Robitussin Allergy & Cough, ENT, Rynex DM, Bromaline, AccuHist PDX Syrup, Show all 290 »Bromaphen, Dimetapp Allergy, BP Allergy DM, DM Cold and Cough, Dimetane DX, Rynex PE, Dime Time Extended Release, Pseubrom, Comtrex Acute Head Cold, Brovex, Seradex, Dimaphen DM, Cold & Cough Childrens, Poly DM, Myphetane DX, Brometane DX, M-END, Alacol, BroveX ADT, Alenaze-D, Brofed, Dimetapp Elixir, Bromhist Pediatric, Bromfenex, Sildec, Staflex, Dristan Cold Maximum Strength, P-Tex, J-Tan PD, Bromax, Tanacof-XR, Prop-A-Tane, Veltane, Histaject, Codimal A, Cophene B, B-Vex, LoHist-12, VaZol, Lodrane 12 Hour, Lodrane 24, J-Tan, Brovex CT, Nasahist B, ND-Stat, Dimetane Extentab, Siltane, Respa BR, Bidhist, Lodrane XR, Trexbrom (old formulation), V-COF, BetaTan, Vazotan, Pulmari, Trexbrom, Atuss DA, Y-Tuss, Dicel CD, SymPak II, Nalex AC, BroveX CB, BroveX CBX, EndaCof-AC, BroveX PB C, BroveX PB CX, TL-Hist CD, Poly-Tussin AC, M-End PE, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, Polytine CS, M-End WC, Mar-cof BP, Rydex, Mesehist WC, Uni-Hist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Bromhist-PDX, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Niva-Hist DM, Alahist DM (old formulation), BroveX PB DM, BPM DM PHEN, Duravent DPB, Alacol DM, Presgen B, Y-COF DMX, TL-Hist DM, Tusdec-DM, Bromtuss DM, Dur-Tann DM, Tussi-Pres B, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Dimetapp Children's Multi-Symptom Cold Relief Dye-Free, Balacall DM, Brotapp PE-DM, Lohist-DM, Glenmax PEB DM, Bromatan-DM, Glenmax PEB DM Forte, DuraTan DM, EndaCof-DM, AP-Hist DM, M-Hist DM, Relcof DM, Histinex DM, Prohistine DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Poly Histine DM, Durahistine DM, Dimetapp DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Bromadine-DM, Anaplex DM, Bromphenex DM, Brotapp-DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Centussin DHC, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist, Ala-Hist D, Tusnel-HC, VasoTuss HC, BPM PE HC, Canges-HC NR, FluTuss HC, VazoTuss HC, Canges-HC, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Rhinabid, Bromfenex PE, Bromfenex PE Pediatric, Bromfed-PD Capsules, Rhinabid PD, BPM PE, B-Vex D, Bromaphedrine D, Alenaze-D NR, VaZol-D, Dimaphen Elixir, VazoBid, BroveX PB, Entre-B, Relhist BP, LoHist PEB, BroveX-D, J-Tan D, Dimetane Decongestant, Vazotab, BroveX PEB, Ru-Hist D, Zotex-PE, V-HIST, Phenyl 7.5/6mg, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Brohist D, Decon-A, RespaHist II, Brotapp PE, Tanabid SR, Seradex-LA, Vazobid-PD, Dibrom, Altatapp, Myphetapp, Lodrane, LoHist PSB, Bromfed PD, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Endafed, Touro A&H, Shellcap, Allent, Shellcap PD, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Lodrane Liquid, Nalfed, Touro Allergy, Andehist NR Syrup, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brotapp, Brovex SR, Dimaphen, Lodrane 24D, LoHist-PD, LoHist-12D, J-TanD PD

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[1] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[2]

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3,4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


Mortimer EA, Jr. Drug toxicity from breast milk? Pediatrics 1977;60:780-1. Letter. PMID: 917668. [PubMed: 917668]
Ito S, Blajchman A, Stephenson M, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393–9. [PubMed: 8498418]
Messinis IE, Souvatzoglou A, Fais N, et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143–6. [PubMed: 3928731]
Pontiroli AE, De Castro e Silva E, Mazzoleni F, et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: Sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924–8. [PubMed: 7228996]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding



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Further information

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