Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Cough, Resperal-DM, Dimetapp Elixir, Rynex DM, Alahist DM, Bromaline, Bromph DM, Brotapp-DM, Show all 283 »M-End PE, Dimaphen Elixir, BromTann/DM Tann/PSE Tann, Shellcap, Cold & Cough Childrens, Dimaphen DM, Dimetapp DM, Brotapp, Ru-Hist D, Rhinabid, Dimetane DX, Bromaline DM, Poly-Tussin AC, Histacol BD Drops, Alacol, Q-Tapp, Dimetapp Children's Cold & Allergy, ENT, Presgen B, Bromatan-DM, Lodrane, Bromfenex, BroveX ADT, Dimaphen, Sildec, Rynex PE, Bromtapp-DM, Bromax, Ala-Hist D, Visvex, Bromph HD, Comtrex Acute Head Cold, Ala-Hist, Cophene B, Seradex, VaZol, B-Vex, Bromfed-PD Capsules, ProHist DM, P-Hist DM Drops, BPM PE, Rhinabid PD, Alenaze-D NR, LoHist PEB, Relhist BP, BroveX-D, J-Tan D, Dimetane Decongestant, Entre-B, BroveX PB, Bromaphedrine D, Carbodex DM Syrup, VaZol-D, VazoBid, B-Vex D, Centussin DHC, Anaplex HD, Drocon-CS, M-END, Canges-HC, Vazotab, Bromplex HD, SymTan A, Brovex HC, Endacof HC, Bromcomp HC, VazoTuss HC, FluTuss HC, Poly-Tussin DHC, J-Tan D HC, Sildec DM, Bromfenex PE, EndaCof-DH, J-Cof DHC, Canges-HC NR, BPM PE HC, VasoTuss HC, Tusnel-HC, Bromfenex PE Pediatric, Seradex-LA, Histex SR, Bromfenex PD, Pseubrom-PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Ultrabrom PD, Iofed PD, Allent, Touro A&H, Shellcap PD, Lodrane LD, Respahist, Nalfed PD, Lodrane Liquid, Nalfed, Brovex SR, Bromhist-NR, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Di-Bromm, Unit-Hist Drops, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Endafed, Bromhist Pediatric, RespaHist II, Decon-A, Brotapp PE, Tanabid SR, Vazobid-PD, Brom Tann, Alenaze-D, Brohist D, V-HIST, Zotex-PE, Phenyl 7.5/6mg, Phenyl 15/12mg, Brom Tann PE, J-Tan D SR, Dime Time Extended Release, Dibrom, Lodrane D, Rynex PSE, BroveX PSE, BroveX PD, B-Vex PD, BroveX PSB, Lodrane 12D, Bidhist-D, Myphetapp, Altatapp, LoHist PSB, Brofed, Bromfed SR, Bromfed PD, BroveX PEB, Bromphenex DM, Liquihistine CS, Trihist-CS, Poly-Histine CS, Poly CS, Polytine CS, Mar-cof BP, M-End WC, Myphetane DC, Dimetane DC, BroveX CBX, BroveX CB, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, Rydex, Mesehist WC, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Niva-Hist DM, BPM DM PHEN, BroveX PB DM, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Bromhist-PDX, Nalex AC, SymPak II, LoHist-12, Codimal A, Lodrane 12 Hour, Lodrane 24, J-Tan, Brovex, Histaject, Veltane, P-Tex, Dristan Cold Maximum Strength, Bromaphen, J-Tan PD, Prop-A-Tane, Tanacof-XR, Brovex CT, Nasahist B, BetaTan, V-COF, Vazotan, Pulmari, Dicel CD, Trexbrom, Trexbrom (old formulation), Lodrane XR, Dimetapp Allergy, ND-Stat, Dimetane Extentab, Siltane, Bidhist, Respa BR, Duravent DPB, Alacol DM, Myphetane DX, Dallergy DM, Bromanate DX Cough, Bromatane DX, Bromophed-DX, Myphetane DX Cough, Neo DM Syrup, Bromdex D, BroveX PSE DM Tablets, PediaHist DM, BroveX PSE DM, PBM Allergy, Anaplex DMX, BroveX PSB DM, Liquiphed DM, Brometane DX, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Q-Tapp DM, Robitussin Allergy & Cough, Uni-Hist PDX Drops, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Anaplex DM, Bromadine-DM, Staflex, Andehist DM NR Syrup, PSE Brom DM, Bromaxefed DM RF Syrup, AccuHist DM Pediatric Drops, EndaCof PD Drops, LoHist PEB DM, BPM PE DM, Balacall DM, Brotapp PE-DM, DuraTan DM, Lohist-DM, BroveX PEB DM, Tussi-Pres B, Y-COF DMX, BP Allergy DM, TL-Hist DM, Tusdec-DM, Dur-Tann DM, Bromtuss DM, EndaCof-DM, AP-Hist DM, Liquihistine DM, Uni Multihist DM, Trihist DM, Poly Histine DM, Durahistine DM, DM Cold and Cough, KG Hist DM, Iohist DM, Prohistine DM, Histinex DM, Poly DM, Highland DM, Polytine DM, Delhistine DM, Allanhist PDX Drops
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Drug class: antihistamines
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