Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Children's Cold & Cough, ENT, Dimetapp Elixir, Bromaline, Bromphenex DM, Alenaze-D, Bromhist-PDX, Show all 283 »Lodrane, Brotapp-DM, Robitussin Allergy & Cough, Siltane, V-COF, Carbofed DM Syrup, Bromph DM, Bromfenex, Alenaze-D NR, Lodrane 12D, Brofed, Alacol, Entre-B, Ru-Hist D, Phenyl 7.5/6mg, Dimetapp DM, Histex SR, AccuHist Pediatric, Cophene B, VaZol, Dimetapp Allergy, Rynex DM, BroveX PB DM, Presgen B, TL-Hist DM, Tussi-Pres B, Bromfenex PE Pediatric, Rynex PE, J-Tan D, BroveX-D, LoHist PEB, Relhist BP, VaZol-D, BroveX PB, VazoBid, Dimaphen Elixir, Bromfenex PE, Bromaphedrine D, B-Vex D, BPM PE, Rhinabid PD, Bromfed-PD Capsules, Staflex, Rhinabid, BPM PE HC, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Centussin DHC, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist, Ala-Hist D, Tusnel-HC, VasoTuss HC, Canges-HC NR, Vazotab, FluTuss HC, VazoTuss HC, Canges-HC, M-END, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Bromcomp HC, Endacof HC, Brovex HC, SymTan A, J-Tan D HC, Dimetane Decongestant, Brotapp PE, BroveX ADT, Touro Allergy, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Andehist NR Syrup, Allent, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brotapp, Brovex SR, Dimaphen, Lodrane 24D, LoHist-PD, LoHist-12D, Shellcap PD, Shellcap, BroveX PEB, Dime Time Extended Release, Zotex-PE, V-HIST, Dimetapp Children's Cold & Allergy, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Brohist D, Decon-A, RespaHist II, Allanhist PDX Drops, Tanabid SR, Seradex-LA, Vazobid-PD, Dibrom, Touro A&H, Altatapp, Myphetapp, LoHist PSB, Bromfed PD, Bromfed SR, Bidhist-D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Histacol BD Drops, Andehist DM NR Syrup, Uni-Hist PDX Drops, Polytine CS, BroveX CBX, EndaCof-AC, BroveX PB C, BroveX PB CX, TL-Hist CD, Poly-Tussin AC, M-End PE, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, M-End WC, Nalex AC, Mar-cof BP, Rydex, Mesehist WC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Niva-Hist DM, BroveX CB, SymPak II, Duravent DPB, Lodrane 24, Dristan Cold Maximum Strength, P-Tex, Bromaphen, J-Tan PD, Bromax, Tanacof-XR, Prop-A-Tane, Veltane, Histaject, Codimal A, B-Vex, LoHist-12, Lodrane 12 Hour, Brovex, Dicel CD, J-Tan, Brovex CT, Nasahist B, ND-Stat, Dimetane Extentab, Respa BR, Bidhist, Lodrane XR, Trexbrom (old formulation), BetaTan, Vazotan, Pulmari, Seradex, Trexbrom, BPM DM PHEN, Alacol DM, Q-Tapp DM, Bromatane DX, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Dimetane DX, Myphetane DX, Bromanate DX Cough, Myphetane DX Cough, EndaCof PD Drops, Bromophed-DX, Liquiphed DM, Brometane DX, Bromadine-DM, Anaplex DM, Comtrex Acute Head Cold, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, AccuHist DM Pediatric Drops, Durahistine DM, BP Allergy DM, Bromatan-DM, Y-COF DMX, Tusdec-DM, Bromtuss DM, Dur-Tann DM, Dimaphen DM, Cold & Cough Childrens, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Alahist DM, Balacall DM, Brotapp PE-DM, Lohist-DM, DuraTan DM, DM Cold and Cough, EndaCof-DM, AP-Hist DM, Histinex DM, Prohistine DM, Poly DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Poly Histine DM, J-TanD PD
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Drug class: antihistamines