Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Cough, Robitussin Allergy & Cough, Resperal-DM, Tusdec-DM, BroveX ADT, Dimetapp Children's Cold & Allergy, Bromaline, Comtrex Acute Head Cold, Show all 290 »Rynex DM, Dimetane DX, Brovex, Seradex, Histacol BD Drops, Brometane DX, M-End PE, Y-Tuss, Siltane, Lodrane D, Cold & Cough Childrens, Decon-A, Alacol, Dimetapp Elixir, Rhinabid, Bromfenex PE, Bromfenex PE Pediatric, Staflex, Bromfed-PD Capsules, Entre-B, Dimetane Decongestant, J-Tan D, BroveX-D, LoHist PEB, Relhist BP, Rynex PE, BroveX PB, Rhinabid PD, VazoBid, Dimaphen Elixir, VaZol-D, Alenaze-D NR, Bromaphedrine D, B-Vex D, J-Tan D HC, BPM PE, Bromph HD, SymTan A, Ala-Hist, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Centussin DHC, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist D, Brovex HC, Drocon-CS, Endacof HC, Bromcomp HC, Visvex, BroveX PEB, Bromplex HD, Anaplex HD, M-END, Tusnel-HC, Canges-HC, VazoTuss HC, FluTuss HC, Canges-HC NR, BPM PE HC, VasoTuss HC, Vazotab, Brom Tann PE, Ru-Hist D, Touro Allergy, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Andehist NR Syrup, Shellcap PD, Bromhist-NR, LoHist-12D, LoHist-PD, Lodrane 24D, Dimaphen, Brovex SR, Brotapp, Di-Bromm, Bromaxefed RF Syrup, Unit-Hist Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Bromhist Pediatric Drops, Q-Tapp, Sildec, Lodrane LD, Allent, Zotex-PE, RespaHist II, Dibrom, Dime Time Extended Release, Vazobid-PD, Seradex-LA, Tanabid SR, Brotapp PE, Alenaze-D, Altatapp, Brohist D, Bromplex DM, J-Tan D SR, Phenyl 15/12mg, Phenyl 7.5/6mg, V-HIST, ENT, Myphetapp, Shellcap, BroveX PSE, Touro A&H, Endafed, Bromhist Pediatric, B-Vex PD, BroveX PSB, BroveX PD, Rynex PSE, Lodrane, Lodrane 12D, Bidhist-D, Bromfed SR, Bromfed PD, Brofed, LoHist PSB, Bromhist-DM Drops, Bromphenex DM, Uni-Hist DM Pediatric Drops, M-End WC, BroveX CB, BroveX CBX, EndaCof-AC, BroveX PB C, BroveX PB CX, TL-Hist CD, Poly-Tussin AC, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, Polytine CS, Mar-cof BP, SymPak II, Rydex, Mesehist WC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Bromhist-PDX, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Niva-Hist DM, Nalex AC, Dicel CD, BroveX PB DM, Lodrane 12 Hour, Dristan Cold Maximum Strength, P-Tex, Bromaphen, J-Tan PD, Bromax, Tanacof-XR, Prop-A-Tane, Veltane, Histaject, Codimal A, Cophene B, B-Vex, LoHist-12, VaZol, Lodrane 24, Atuss DA, Lodrane XR, Trexbrom, Pulmari, Vazotan, BetaTan, V-COF, Trexbrom (old formulation), Bidhist, J-Tan, Respa BR, Dimetane Extentab, Dimetapp Allergy, ND-Stat, Nasahist B, Brovex CT, Alahist DM (old formulation), BPM DM PHEN, Carbofed DM Syrup, Neo DM Syrup, Poly Histine DM, DM Cold and Cough, Durahistine DM, Dimetapp DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Dallergy DM, Liquihistine DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Myphetane DX Cough, Bromophed-DX, Liquiphed DM, Bromadine-DM, Anaplex DM, Brotapp-DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Trihist DM, Uni Multihist DM, Duravent DPB, Brotapp PE-DM, Alacol DM, BP Allergy DM, Presgen B, Y-COF DMX, TL-Hist DM, Bromtuss DM, Dur-Tann DM, Dimaphen DM, Tussi-Pres B, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Dimetapp Children's Multi-Symptom Cold Relief Dye-Free, Balacall DM, Lohist-DM, KG Hist DM, Histinex DM, Iohist DM, Polytine DM, Delhistine DM, Highland DM, Poly DM, Prohistine DM, Relcof DM, Glenmax PEB DM, M-Hist DM, AP-Hist DM, EndaCof-DM, DuraTan DM, Glenmax PEB DM Forte, Bromatan-DM, J-TanD PD
Medically reviewed by Drugs.com. Last updated on Jan 28, 2021.
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. [PubMed: 8498418]
Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. [PubMed: 917668]
Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. [PubMed: 3928731]
Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. [PubMed: 7228996]
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