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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dime Time Extended Release, Seradex, Robitussin Allergy & Cough, Dimetane DX, VasoTuss HC, Ala-Hist, Cold & Cough Childrens, Show all 288 »Histinex DM, Seradex-LA, Comtrex Acute Head Cold, Dimetapp Allergy, Rhinabid, Bromfenex PE, J-Tan D HC, Bromfenex PE Pediatric, Bromfed-PD Capsules, Rhinabid PD, BPM PE, Staflex, Alenaze-D NR, B-Vex D, Relhist BP, BroveX ADT, Vazotab, Dimetane Decongestant, J-Tan D, BroveX-D, LoHist PEB, Rynex PE, Bromaphedrine D, Entre-B, Alacol, BroveX PB, VazoBid, Dimaphen Elixir, VaZol-D, Brovex HC, SymTan A, Anaplex HD, Endacof HC, Poly-Tussin DHC, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Bromph DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Sildec DM, Centussin DHC, EndaCof-DH, Bromcomp HC, J-Cof DHC, Ala-Hist D, Tusnel-HC, BPM PE HC, Canges-HC NR, FluTuss HC, VazoTuss HC, Canges-HC, M-END, Drocon-CS, Ru-Hist D, Bromplex HD, Bromph HD, Visvex, BroveX PEB, Dimetapp Children's Cold & Allergy, Zotex-PE, Histex SR, Nalfed, Lodrane Liquid, Pseubrom, Iofed, Ultrabrom, M-Hist TD, Bromfenex PD, Andehist NR Syrup, Bromfenex, Pseubrom-PD, Ultrabrom PD, Iofed PD, Respahist, Nalfed PD, Touro Allergy, Bromaline, Shellcap PD, Bromhist-NR, LoHist-12D, LoHist-PD, Lodrane 24D, Dimaphen, Brovex SR, Brotapp, Di-Bromm, Bromaxefed RF Syrup, Unit-Hist Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Bromhist Pediatric Drops, Q-Tapp, Sildec, Lodrane LD, Allent, V-HIST, Decon-A, ENT, Dibrom, Vazobid-PD, Tanabid SR, Brotapp PE, RespaHist II, Alenaze-D, Myphetapp, Brohist D, Brom Tann PE, J-Tan D SR, Phenyl 15/12mg, Phenyl 7.5/6mg, Carbofed DM Syrup, Altatapp, Lodrane, Shellcap, BroveX PSE, Touro A&H, Endafed, Bromhist Pediatric, B-Vex PD, BroveX PSB, BroveX PD, Lodrane D, LoHist PSB, Rynex PSE, Dimetapp Elixir, Lodrane 12D, Bidhist-D, Bromfed SR, Bromfed PD, Brofed, Uni-Hist DM Pediatric Drops, Andehist DM NR Syrup, Bromaline DM, Polytine CS, BroveX CB, BroveX CBX, EndaCof-AC, BroveX PB C, BroveX PB CX, TL-Hist CD, Poly-Tussin AC, M-End PE, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, M-End WC, SymPak II, Acutuss DM Pediatric, Niva-Hist DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Bromhist-DM, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Bromhist-PDX, Mar-cof BP, EndaCof-PD, Allanhist PDX Syrup, Uni-Hist PDX Syrup, AccuHist PDX Syrup, Mesehist WC, Rydex, Nalex AC, Dicel CD, Rynex DM, Lodrane 12 Hour, Dristan Cold Maximum Strength, P-Tex, Bromaphen, J-Tan PD, Bromax, Tanacof-XR, Prop-A-Tane, Veltane, Histaject, Codimal A, Cophene B, B-Vex, LoHist-12, VaZol, Lodrane 24, Trexbrom, Bidhist, Pulmari, Vazotan, BetaTan, V-COF, Trexbrom (old formulation), Lodrane XR, Respa BR, Brovex, Siltane, Dimetane Extentab, ND-Stat, Nasahist B, Brovex CT, J-Tan, Alahist DM (old formulation), BroveX PB DM, PSE Brom DM, BromTann/DM Tann/PSE Tann, Liquihistine DM, Trihist DM, Poly Histine DM, DM Cold and Cough, Durahistine DM, Dimetapp DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, Bromdex D, KG Hist DM, Brometane DX, Bromaxefed DM RF Syrup, Bromtapp-DM, Brotapp-DM, Bromphenex DM, Anaplex DM, Bromadine-DM, Liquiphed DM, Neo DM Syrup, Bromophed-DX, Myphetane DX Cough, Bromatane DX, Bromanate DX Cough, Myphetane DX, Dallergy DM, Uni Multihist DM, Iohist DM, BPM DM PHEN, LoHist PEB DM, Duravent DPB, Alacol DM, BP Allergy DM, Presgen B, Y-COF DMX, TL-Hist DM, Tusdec-DM, Bromtuss DM, Dur-Tann DM, Dimaphen DM, Tussi-Pres B, Dimetapp Children's Cold & Cough, BroveX PEB DM, BPM PE DM, Dimetapp Children's Multi-Symptom Cold Relief Dye-Free, Polytine DM, AP-Hist DM, Delhistine DM, Highland DM, Poly DM, Prohistine DM, Relcof DM, M-Hist DM, EndaCof-DM, Balacall DM, DuraTan DM, Glenmax PEB DM Forte, Bromatan-DM, Glenmax PEB DM, Lohist-DM, Brotapp PE-DM, J-TanD PD

Medically reviewed by Last updated on Jun 25, 2020.

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. [PubMed: 8498418]
Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. [PubMed: 917668]
Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. [PubMed: 3928731]
Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. [PubMed: 7228996]

Substance Identification

Substance Name


CAS Registry Number


Drug Class

  • Breast Feeding
  • Lactation
  • Antihistamines

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Further information

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