Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Cough, Resperal-DM, Rynex DM, Dimetapp Elixir, M-End PE, Bromaline, Dimetapp Allergy, Ru-Hist D, Show all 283 »Dimaphen Elixir, Robitussin Allergy & Cough, Bromph DM, Brotapp-DM, BromTann/DM Tann/PSE Tann, Dimetapp DM, Dimetane DX, Alacol, Rynex PE, Bromtapp-DM, Rhinabid, Bromophed-DX, Histacol BD Drops, BroveX ADT, Cold & Cough Childrens, Dimaphen DM, BPM PE DM, Bromatan-DM, DM Cold and Cough, Presgen B, Shellcap, Dimaphen, Brotapp, Sildec, Bromfenex, Vazotab, Poly-Tussin AC, Visvex, Dristan Cold Maximum Strength, M-END, Brovex, Cophene B, VaZol, Ala-Hist D, Ala-Hist, Seradex, Bromaphedrine D, BPM PE, B-Vex D, Centussin DHC, Sildec DM, Carbodex DM Syrup, P-Hist DM Drops, VazoBid, BroveX-D, J-Tan D, Dimetane Decongestant, BroveX PEB, LoHist PEB, Relhist BP, VaZol-D, Rhinabid PD, BroveX PB, Entre-B, Alenaze-D NR, Poly-Tussin DHC, Bromplex HD, Anaplex HD, Drocon-CS, Canges-HC, Bromph HD, Zotex-PE, SymTan A, Brovex HC, Endacof HC, Bromcomp HC, VazoTuss HC, FluTuss HC, J-Cof DHC, EndaCof-DH, J-Tan D HC, Bromfenex PE Pediatric, Tusnel-HC, VasoTuss HC, Canges-HC NR, BPM PE HC, Bromfenex PE, Bromfed-PD Capsules, Tanabid SR, Histex SR, Bromfenex PD, Pseubrom-PD, M-Hist TD, Ultrabrom, Pseubrom, Iofed, Ultrabrom PD, Iofed PD, Allent, Touro A&H, Shellcap PD, Lodrane LD, Respahist, Nalfed PD, Lodrane Liquid, Nalfed, Brovex SR, Bromhist-NR, Di-Bromm, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Unit-Hist Drops, Unit-Tex 10/120 ER, Andehist NR Syrup, Touro Allergy, Bromaxefed RF Syrup, Q-Tapp, AccuHist Pediatric, Bromhist Pediatric Drops, Endafed, Bromhist Pediatric, ProHist DM, Brotapp PE, RespaHist II, Seradex-LA, Vazobid-PD, Dibrom, Dime Time Extended Release, Decon-A, Alenaze-D, Phenyl 7.5/6mg, Dimetapp Children's Cold & Allergy, Phenyl 15/12mg, J-Tan D SR, Brohist D, Brom Tann PE, ENT, Altatapp, Lodrane D, Rynex PSE, BroveX PSE, BroveX PD, B-Vex PD, BroveX PSB, Lodrane 12D, Bidhist-D, Lodrane, Myphetapp, LoHist PSB, Brofed, Bromfed SR, Bromfed PD, V-HIST, Bromphenex DM, Trihist-CS, Poly-Histine CS, Liquihistine CS, Poly CS, M-End WC, Polytine CS, Myphetane DC, Dimetane DC, BroveX CBX, BroveX CB, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, Mar-cof BP, Rydex, Bromhist-DM, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Histacol DM Pediatric Syrup, BroveX PB DM, Niva-Hist DM, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, AccuHist PDX Syrup, Mesehist WC, Uni-Hist PDX Syrup, Allanhist PDX Syrup, Bromhist-PDX, EndaCof-PD, Nalex AC, SymPak II, Codimal A, Histaject, B-Vex, LoHist-12, Lodrane 24, Lodrane 12 Hour, Veltane, Prop-A-Tane, P-Tex, Comtrex Acute Head Cold, Bromaphen, J-Tan PD, Tanacof-XR, Bromax, J-Tan, Brovex CT, BetaTan, V-COF, Vazotan, Pulmari, Dicel CD, Trexbrom, Trexbrom (old formulation), Lodrane XR, ND-Stat, Nasahist B, Dimetane Extentab, Siltane, Bidhist, Respa BR, BPM DM PHEN, Duravent DPB, Myphetane DX, Dallergy DM, Bromanate DX Cough, Bromatane DX, Liquiphed DM, Myphetane DX Cough, Neo DM Syrup, Bromdex D, BroveX PSE DM Tablets, PediaHist DM, BroveX PSE DM, PBM Allergy, Anaplex DMX, BroveX PSB DM, Brometane DX, Bromadine-DM, Bromhist-DM Drops, Bromplex DM, Pediahist DM Drops, Q-Tapp DM, Allanhist PDX Drops, Uni-Hist PDX Drops, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Staflex, Anaplex DM, Andehist DM NR Syrup, Bromaxefed DM RF Syrup, Bromaline DM, PSE Brom DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, LoHist PEB DM, BroveX PEB DM, Alahist DM, Balacall DM, Lohist-DM, Brotapp PE-DM, Tussi-Pres B, Dur-Tann DM, BP Allergy DM, Alacol DM, Y-COF DMX, TL-Hist DM, Bromtuss DM, Tusdec-DM, DuraTan DM, EndaCof-DM, Uni Multihist DM, KG Hist DM, Liquihistine DM, Trihist DM, Durahistine DM, Poly Histine DM, Iohist DM, Polytine DM, Histinex DM, AP-Hist DM, Prohistine DM, Poly DM, Delhistine DM, Highland DM, Brom Tann
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
CAS Registry Number
LactMed Record Number
Last Revision Date
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
More about brompheniramine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- En Español
- 7 Reviews – Add your own review/rating
- Brompheniramine 12-hour sustained-release tablets
- Brompheniramine 24-hour sustained-release capsules
- Brompheniramine chewable tablets
- Brompheniramine liquid
- Brompheniramine suspension