Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Bromaline, Resperal-DM, Dimetapp Children's Cold & Cough, Dimetapp Elixir, Robitussin Allergy & Cough, Rynex DM, Dimaphen, Bromphenex DM, Show all 287 »Brotapp, Ala-Hist, Decon-A, Brovex, Ru-Hist D, Rynex PE, Brotapp-DM, Lodrane, Dime Time Extended Release, Dimetane DX, BroveX PB CX, Poly-Tussin AC, Carbofed DM Syrup, Bromadine-DM, Brometane DX, BroveX PB C, Bromhist-DM Drops, Staflex, Dimetapp DM, Alenaze-D NR, BroveX PB, Alenaze-D, Bromfenex PD, BroveX PD, BroveX PB DM, Dimaphen DM, Alahist DM, DM Cold and Cough, Dimetapp Children's Cold & Allergy, M-End PE, Bromph DM, Comtrex Acute Head Cold, Dimetapp Allergy, Veltane, Bromax, J-Tan PD, Bromaphen, M-END, Seradex, Bidhist, Sildec DM, VaZol-D, Bromaphedrine D, Bromfenex PE, B-Vex D, VazoBid, BPM PE, Dimaphen Elixir, Alacol, Bromfed-PD Capsules, Bromfenex PE Pediatric, Entre-B, Relhist BP, LoHist PEB, BroveX-D, Rhinabid PD, Poly-Tussin DHC, Rhinabid, Drocon-CS, SymTan A, Brovex HC, Endacof HC, Dimetane Decongestant, Bromcomp HC, Visvex, Bromph HD, Bromplex HD, Anaplex HD, Canges-HC, Centussin DHC, VazoTuss HC, FluTuss HC, Canges-HC NR, BPM PE HC, VasoTuss HC, Tusnel-HC, Ala-Hist D, J-Cof DHC, EndaCof-DH, J-Tan D HC, J-Tan D, Tanabid SR, Vazotab, Nalfed, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Touro Allergy, Allent, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, Lodrane 24D, LoHist-PD, LoHist-12D, Shellcap PD, Shellcap, BroveX ADT, ENT, BroveX PEB, Zotex-PE, V-HIST, Phenyl 7.5/6mg, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Brohist D, RespaHist II, Brotapp PE, P-Hist DM Drops, Seradex-LA, Vazobid-PD, Dibrom, Altatapp, Touro A&H, Myphetapp, LoHist PSB, Brofed, Bromfed PD, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, Carbodex DM Syrup, Bromophed-DX, ProHist DM, Uni-Hist PDX Syrup, TL-Hist CD, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, Polytine CS, M-End WC, Mar-cof BP, Rydex, Mesehist WC, AccuHist PDX Syrup, Allanhist PDX Syrup, BroveX CBX, EndaCof-PD, Bromhist-PDX, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Niva-Hist DM, BPM DM PHEN, Duravent DPB, Alacol DM, BP Allergy DM, EndaCof-AC, BroveX CB, Y-COF DMX, Brovex CT, Dristan Cold Maximum Strength, P-Tex, Tanacof-XR, Prop-A-Tane, Histaject, Codimal A, Cophene B, B-Vex, LoHist-12, VaZol, Lodrane 12 Hour, Lodrane 24, J-Tan, Nasahist B, Nalex AC, ND-Stat, Dimetane Extentab, Siltane, Respa BR, Lodrane XR, Trexbrom (old formulation), V-COF, BetaTan, Vazotan, Pulmari, Trexbrom, Dicel CD, SymPak II, Presgen B, TL-Hist DM, Brom Tann, Myphetane DX Cough, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Myphetane DX, Bromanate DX Cough, Bromatane DX, Liquiphed DM, EndaCof PD Drops, Anaplex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Pediahist DM Drops, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Histacol BD Drops, AccuHist DM Pediatric Drops, Durahistine DM, Tusdec-DM, DuraTan DM, Bromtuss DM, Dur-Tann DM, Tussi-Pres B, Cold & Cough Childrens, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Balacall DM, Brotapp PE-DM, Lohist-DM, Glenmax PEB DM, Bromatan-DM, Glenmax PEB DM Forte, EndaCof-DM, Poly Histine DM, AP-Hist DM, M-Hist DM, Relcof DM, Histinex DM, Prohistine DM, Poly DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, J-TanD PD
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Drug class: antihistamines