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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Dimetapp Children's Cold & Cough, Brovex, Robitussin Allergy & Cough, Dimetapp Elixir, LoHist-12, Dime Time Extended Release, Alahist DM, Show all 283 »Bromaline, Lodrane, Bromax, Lodrane D, Seradex, J-Tan PD, Brotapp, Rynex DM, J-Tan, Lodrane 24, Lodrane 12 Hour, Dimetane Extentab, Siltane, Dimetane DX, Cold & Cough Childrens, Duravent DPB, Q-Tapp, Bromaline DM, DM Cold and Cough, Brovex CT, VaZol, Mesehist WC, AccuHist PDX Syrup, Sildec, Bromhist-DM, Brofed, Bromhist Pediatric, Histex SR, Staflex, Alacol, Vazotab, Dimetane Decongestant, BroveX ADT, BroveX PEB, Zotex-PE, Ru-Hist D, J-Tan D, BroveX-D, BroveX PB, VazoBid, Entre-B, Rynex PE, LoHist PEB, Relhist BP, Dimaphen Elixir, Rhinabid PD, BPM PE HC, VasoTuss HC, Tusnel-HC, Canges-HC NR, FluTuss HC, M-END, Canges-HC, VazoTuss HC, Ala-Hist D, Ala-Hist, Sildec DM, Carbodex DM Syrup, P-Hist DM Drops, Centussin DHC, Poly-Tussin DHC, J-Cof DHC, EndaCof-DH, Drocon-CS, Anaplex HD, Bromfed-PD Capsules, Bromfenex PE Pediatric, Bromfenex PE, V-HIST, BPM PE, Alenaze-D NR, Bromaphedrine D, B-Vex D, Rhinabid, J-Tan D HC, Visvex, Bromph HD, Bromplex HD, Bromcomp HC, Endacof HC, SymTan A, Brovex HC, VaZol-D, ENT, Ultrabrom, M-Hist TD, Iofed, Pseubrom, Nalfed, Lodrane Liquid, Bromfenex PD, Bromfenex, Nalfed PD, Lodrane LD, Respahist, Iofed PD, Pseubrom-PD, Ultrabrom PD, Touro Allergy, Andehist NR Syrup, Dimaphen, Brovex SR, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Bromhist-NR, Di-Bromm, Bromhist Pediatric Drops, Bromaxefed RF Syrup, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Shellcap PD, Allent, Tanabid SR, Brotapp PE, Seradex-LA, Vazobid-PD, ProHist DM, Dibrom, RespaHist II, Decon-A, Phenyl 15/12mg, Phenyl 7.5/6mg, J-Tan D SR, Brom Tann PE, Alenaze-D, Brohist D, Altatapp, Myphetapp, BroveX PSB, BroveX PD, B-Vex PD, Endafed, Shellcap, Touro A&H, BroveX PSE, Rynex PSE, Bromfed PD, LoHist PSB, Bromfed SR, Bidhist-D, Lodrane 12D, Dimetapp Children's Cold & Allergy, Bromtapp-DM, M-End WC, Polytine CS, Mar-cof BP, Rydex, Allanhist PDX Syrup, Uni-Hist PDX Syrup, Poly CS, Liquihistine CS, M-End PE, Poly-Tussin AC, Dimetane DC, Myphetane DC, Trihist-CS, Poly-Histine CS, EndaCof-PD, Bromhist-PDX, BP Allergy DM, Alacol DM, Presgen B, Y-COF DMX, Tusdec-DM, TL-Hist DM, BPM DM PHEN, BroveX PB DM, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, AccuHist DM Pediatric Syrup, Pediahist DM Syrup, Niva-Hist DM, Histacol DM Pediatric Syrup, TL-Hist CD, BroveX PB CX, Cophene B, Codimal A, B-Vex, Nasahist B, Dimetapp Allergy, ND-Stat, Histaject, Veltane, Dristan Cold Maximum Strength, Comtrex Acute Head Cold, P-Tex, Bromaphen, Prop-A-Tane, Tanacof-XR, Respa BR, Bidhist, Nalex AC, SymPak II, BroveX CB, BroveX CBX, BroveX PB C, EndaCof-AC, Dicel CD, Trexbrom, Trexbrom (old formulation), Lodrane XR, V-COF, BetaTan, Pulmari, Vazotan, Bromtuss DM, Dur-Tann DM, Myphetane DX Cough, Bromatane DX, Bromophed-DX, Liquiphed DM, Bromadine-DM, Brometane DX, Bromanate DX Cough, Myphetane DX, Anaplex DMX, BroveX PSB DM, BromTann/DM Tann/PSE Tann, Bromdex D, Dallergy DM, Neo DM Syrup, Anaplex DM, Bromphenex DM, Q-Tapp DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, Andehist DM NR Syrup, Brotapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, PBM Allergy, BroveX PSE DM, DuraTan DM, Bromatan-DM, EndaCof-DM, AP-Hist DM, Prohistine DM, Histinex DM, Lohist-DM, Brotapp PE-DM, Tussi-Pres B, Dimaphen DM, BroveX PEB DM, BPM PE DM, Balacall DM, LoHist PEB DM, Poly DM, Highland DM, Dimetapp DM, Durahistine DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, BroveX PSE DM Tablets, PediaHist DM, Poly Histine DM, Trihist DM, Polytine DM, Delhistine DM, Iohist DM, KG Hist DM, Liquihistine DM, Uni Multihist DM, Brom Tann

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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