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Brompheniramine use while Breastfeeding

Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Robitussin Allergy & Cough, Dimetapp Children's Cold & Cough, Dimetapp Elixir, M-END, Bromfenex, Brotapp, Bromhist-PDX, Show all 283 »Alahist DM, Brovex, Ru-Hist D, BroveX PSE DM Tablets, Dimetane DX, Dimetapp DM, Poly-Tussin AC, Andehist DM NR Syrup, Brotapp-DM, Bromphenex DM, Anaplex DM, Bromophed-DX, Dimaphen, Rynex DM, Dimetapp Children's Cold & Allergy, Dimaphen DM, Bromatan-DM, Poly Histine DM, DM Cold and Cough, Entre-B, Ultrabrom, Alacol, VazoBid, Carbofed DM Syrup, Bromaline, Pseubrom, Alenaze-D NR, Brometane DX, BetaTan, Canges-HC, VasoTuss HC, Dristan Cold Maximum Strength, Bromfed-PD Capsules, Rhinabid, ND-Stat, Siltane, Carbodex DM Syrup, Centussin DHC, Rhinabid PD, BPM PE, B-Vex D, Bromaphedrine D, Sildec DM, P-Hist DM Drops, BroveX-D, J-Tan D, Dimetane Decongestant, Vazotab, LoHist PEB, Relhist BP, Bromfenex PE Pediatric, Dimaphen Elixir, BroveX PB, Rynex PE, VaZol-D, EndaCof-DH, Bromcomp HC, Visvex, Bromph HD, Bromplex HD, Endacof HC, BroveX ADT, J-Tan D HC, SymTan A, Brovex HC, Anaplex HD, Drocon-CS, Ala-Hist D, Ala-Hist, J-Cof DHC, Poly-Tussin DHC, Tusnel-HC, BPM PE HC, VazoTuss HC, FluTuss HC, Canges-HC NR, Bromfenex PE, Decon-A, Bromfenex PD, Pseubrom-PD, Ultrabrom PD, Histex SR, M-Hist TD, Lodrane Liquid, Iofed, Iofed PD, Respahist, Shellcap, Touro A&H, Allent, Shellcap PD, Nalfed PD, Lodrane LD, Nalfed, Touro Allergy, Brovex SR, Bromhist-NR, Di-Bromm, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Unit-Hist Drops, Unit-Tex 10/120 ER, Bromaxefed RF Syrup, Andehist NR Syrup, Sildec, Q-Tapp, AccuHist Pediatric, Bromhist Pediatric Drops, Endafed, Bromhist Pediatric, Brotapp PE, RespaHist II, ProHist DM, Tanabid SR, Seradex-LA, Dime Time Extended Release, Vazobid-PD, Alenaze-D, Brohist D, V-HIST, Zotex-PE, Phenyl 7.5/6mg, Phenyl 15/12mg, Brom Tann PE, J-Tan D SR, Dibrom, ENT, Lodrane D, Rynex PSE, Lodrane 12D, BroveX PSE, BroveX PD, B-Vex PD, BroveX PSB, Bidhist-D, Bromfed SR, Myphetapp, Altatapp, Lodrane, LoHist PSB, Bromfed PD, Brofed, BroveX PEB, Bromtapp-DM, Myphetane DC, Dimetane DC, Poly-Histine CS, Trihist-CS, Poly CS, Liquihistine CS, M-End PE, TL-Hist CD, BroveX CB, Nalex AC, BroveX CBX, EndaCof-AC, BroveX PB CX, BroveX PB C, Polytine CS, M-End WC, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Niva-Hist DM, Histacol DM Pediatric Syrup, Acutuss DM Pediatric, EndaCof-PD, Rydex, Mar-cof BP, Mesehist WC, AccuHist PDX Syrup, Allanhist PDX Syrup, Uni-Hist PDX Syrup, SymPak II, Dicel CD, Codimal A, Histaject, Cophene B, B-Vex, VaZol, LoHist-12, Veltane, Prop-A-Tane, P-Tex, Comtrex Acute Head Cold, Bromaphen, J-Tan PD, Tanacof-XR, Bromax, Lodrane 12 Hour, Lodrane 24, V-COF, Trexbrom (old formulation), Vazotan, Pulmari, Trexbrom, Seradex, Lodrane XR, Bidhist, Brovex CT, J-Tan, Nasahist B, Dimetapp Allergy, Respa BR, Dimetane Extentab, BroveX PB DM, BPM DM PHEN, Neo DM Syrup, Bromdex D, Dallergy DM, Myphetane DX, Bromatane DX, Bromanate DX Cough, BromTann/DM Tann/PSE Tann, Anaplex DMX, AccuHist DM Pediatric Drops, EndaCof PD Drops, PediaHist DM, BroveX PSE DM, BroveX PSB DM, PBM Allergy, Myphetane DX Cough, Liquiphed DM, Q-Tapp DM, Pediahist DM Drops, Bromph DM, Uni-Hist PDX Drops, Histacol BD Drops, Allanhist PDX Drops, Bromhist-DM Drops, Bromplex DM, Staflex, Bromadine-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Uni-Hist DM Pediatric Drops, Bromaline DM, Durahistine DM, Trihist DM, Tussi-Pres B, Dur-Tann DM, Cold & Cough Childrens, BroveX PEB DM, LoHist PEB DM, BPM PE DM, Bromtuss DM, Tusdec-DM, Alacol DM, Duravent DPB, BP Allergy DM, Presgen B, TL-Hist DM, Y-COF DMX, Balacall DM, Brotapp PE-DM, Polytine DM, Delhistine DM, Iohist DM, KG Hist DM, Liquihistine DM, Uni Multihist DM, Highland DM, Poly DM, DuraTan DM, Lohist-DM, EndaCof-DM, AP-Hist DM, Prohistine DM, Histinex DM, Brom Tann

Brompheniramine Levels and Effects while Breastfeeding

Summary of Use during Lactation

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.[1]

Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine).[2] These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.

Effects on Lactation and Breastmilk

Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women.[3][4] However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers.[3] Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Alternate Drugs to Consider

Desloratadine, Fexofenadine, Loratadine


1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418

2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668

3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731

4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996

Brompheniramine Identification

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Administrative Information

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