Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Cough, Resperal-DM, Robitussin Allergy & Cough, Rynex DM, Dimetapp Elixir, Bromaline, Ru-Hist D, Seradex, Show all 283 »Dimetapp Allergy, Dimetane DX, Alacol, Dimaphen Elixir, Dimetapp DM, Rhinabid, Vazotab, Sildec, Lodrane, Cold & Cough Childrens, BPM PE DM, DM Cold and Cough, Shellcap, Bromfenex, Mesehist WC, Brotapp, Histex SR, Dimaphen, Bromophed-DX, Ala-Hist D, M-END, Bromax, Dristan Cold Maximum Strength, Brovex, Cophene B, VaZol, Alenaze-D NR, B-Vex D, Histacol BD Drops, Brom Tann, Bromfed-PD Capsules, Rhinabid PD, BPM PE, Bromaphedrine D, VaZol-D, J-Tan D, BroveX-D, Dimetane Decongestant, BroveX ADT, BroveX PEB, LoHist PEB, Relhist BP, VazoBid, ProHist DM, BroveX PB, Entre-B, Rynex PE, Allanhist PDX Drops, Carbodex DM Syrup, J-Tan D HC, SymTan A, Canges-HC, VazoTuss HC, Zotex-PE, Brovex HC, Endacof HC, Bromplex HD, Anaplex HD, Bromph HD, Visvex, Bromcomp HC, FluTuss HC, Canges-HC NR, Poly-Tussin DHC, EndaCof-DH, Centussin DHC, Sildec DM, Drocon-CS, Bromfenex PE Pediatric, Bromfenex PE, VasoTuss HC, BPM PE HC, Tusnel-HC, Ala-Hist, J-Cof DHC, P-Hist DM Drops, Brotapp PE, M-Hist TD, Bromfenex PD, Pseubrom-PD, Ultrabrom, Iofed, Lodrane Liquid, Pseubrom, Ultrabrom PD, Iofed PD, Allent, Touro A&H, Shellcap PD, Lodrane LD, Respahist, Nalfed PD, Nalfed, Touro Allergy, Brovex SR, Bromhist-NR, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Di-Bromm, Unit-Hist Drops, Bromaxefed RF Syrup, Andehist NR Syrup, Q-Tapp, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Endafed, Bromhist Pediatric, Uni-Hist PDX Drops, RespaHist II, Tanabid SR, Seradex-LA, Dime Time Extended Release, Vazobid-PD, Decon-A, Alenaze-D, Phenyl 7.5/6mg, Dimetapp Children's Cold & Allergy, Phenyl 15/12mg, J-Tan D SR, Brohist D, Brom Tann PE, Dibrom, ENT, Lodrane D, Rynex PSE, BroveX PSE, BroveX PD, B-Vex PD, BroveX PSB, Lodrane 12D, Bidhist-D, Myphetapp, Altatapp, LoHist PSB, Brofed, Bromfed SR, Bromfed PD, V-HIST, Bromaxefed DM RF Syrup, Liquihistine CS, Trihist-CS, Poly-Histine CS, Poly CS, Polytine CS, Mar-cof BP, M-End WC, Myphetane DC, Dimetane DC, BroveX PB C, EndaCof-AC, BroveX PB CX, TL-Hist CD, M-End PE, Poly-Tussin AC, Rydex, AccuHist PDX Syrup, Histacol DM Pediatric Syrup, Pediahist DM Syrup, Niva-Hist DM, BroveX PB DM, Duravent DPB, BPM DM PHEN, Bromhist-DM, AccuHist DM Pediatric Syrup, Allanhist PDX Syrup, Uni-Hist PDX Syrup, EndaCof-PD, Bromhist-PDX, Uni-Hist DM Pediatric Syrup, Acutuss DM Pediatric, BroveX CBX, BroveX CB, LoHist-12, B-Vex, Codimal A, Lodrane 12 Hour, Lodrane 24, Brovex CT, J-Tan, Histaject, Veltane, P-Tex, Comtrex Acute Head Cold, Bromaphen, J-Tan PD, Prop-A-Tane, Tanacof-XR, Nasahist B, ND-Stat, Pulmari, Vazotan, Trexbrom, Dicel CD, Nalex AC, SymPak II, BetaTan, V-COF, Siltane, Dimetane Extentab, Respa BR, Bidhist, Trexbrom (old formulation), Lodrane XR, Alacol DM, BP Allergy DM, Myphetane DX, Dallergy DM, Neo DM Syrup, Bromanate DX Cough, Bromatane DX, Liquiphed DM, Myphetane DX Cough, Bromdex D, BromTann/DM Tann/PSE Tann, BroveX PSE DM Tablets, PediaHist DM, BroveX PSE DM, PBM Allergy, Anaplex DMX, BroveX PSB DM, Brometane DX, Bromadine-DM, Uni-Hist DM Pediatric Drops, Carbofed DM Syrup, Bromplex DM, Bromhist-DM Drops, Q-Tapp DM, Pediahist DM Drops, Bromaline DM, PSE Brom DM, Bromphenex DM, Anaplex DM, Brotapp-DM, Andehist DM NR Syrup, Staflex, Bromtapp-DM, AccuHist DM Pediatric Drops, EndaCof PD Drops, Alahist DM, LoHist PEB DM, BroveX PEB DM, Balacall DM, Brotapp PE-DM, Bromatan-DM, Lohist-DM, Tussi-Pres B, Dimaphen DM, Y-COF DMX, Presgen B, TL-Hist DM, Tusdec-DM, Dur-Tann DM, Bromtuss DM, DuraTan DM, EndaCof-DM, Uni Multihist DM, KG Hist DM, Liquihistine DM, Trihist DM, Durahistine DM, Poly Histine DM, Iohist DM, Polytine DM, Histinex DM, AP-Hist DM, Prohistine DM, Poly DM, Delhistine DM, Highland DM, Bromph DM
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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