Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp DM, Bromaline, Robitussin Allergy & Cough, Resperal-DM, Dimetapp Children's Cold & Cough, Lodrane, Rynex DM, Brotapp-DM, Show all 287 »Dimaphen DM, Dimetapp Children's Cold & Allergy, M-END, Dimetapp Elixir, Dimetapp Allergy, Bromfenex, Dimetane DC, ENT, Bromhist-PDX, Brofed, Lodrane D, Rydex, Endafed, Unit-Hist Drops, Brotapp, Andehist DM NR Syrup, Bromaphen, Dimaphen Elixir, Bromax, VazoBid, Dimetane DX, Bromophed-DX, Brometane DX, Bromphenex DM, Bromadine-DM, Bromplex DM, Dime Time Extended Release, Decon-A, Cold & Cough Childrens, Presgen B, Bromcomp HC, Q-Tapp DM, Alacol, Ru-Hist D, Altatapp, Seradex, Sildec DM, Entre-B, BroveX PB, VaZol-D, Bromaphedrine D, B-Vex D, Rynex PE, Alenaze-D NR, BPM PE, Rhinabid PD, Bromfenex PE Pediatric, Rhinabid, Bromfenex PE, Bromfed-PD Capsules, Staflex, J-Tan D HC, VasoTuss HC, Brom Tann, ProHist DM, P-Hist DM Drops, Carbodex DM Syrup, Centussin DHC, Poly-Tussin DHC, EndaCof-DH, J-Cof DHC, Ala-Hist, Ala-Hist D, Tusnel-HC, BPM PE HC, SymTan A, Canges-HC NR, FluTuss HC, VazoTuss HC, Canges-HC, Drocon-CS, Anaplex HD, Bromplex HD, Bromph HD, Visvex, Endacof HC, Brovex HC, LoHist PEB, Relhist BP, Brohist D, BroveX-D, Nalfed, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, Histex SR, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Touro Allergy, Allent, Andehist NR Syrup, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Di-Bromm, Bromhist-NR, Brovex SR, Dimaphen, Lodrane 24D, LoHist-PD, LoHist-12D, Shellcap PD, Shellcap, J-Tan D, Tanabid SR, Dimetane Decongestant, Vazotab, BroveX ADT, BroveX PEB, Zotex-PE, V-HIST, Phenyl 7.5/6mg, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Allanhist PDX Drops, Alenaze-D, RespaHist II, Brotapp PE, Seradex-LA, Touro A&H, Vazobid-PD, Dibrom, Myphetapp, LoHist PSB, Bromfed PD, Bromfed SR, Bidhist-D, Lodrane 12D, Rynex PSE, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Histacol BD Drops, Bromatane DX, Uni-Hist PDX Drops, Polytine CS, BroveX CB, BroveX CBX, EndaCof-AC, BroveX PB C, BroveX PB CX, TL-Hist CD, Poly-Tussin AC, M-End PE, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, M-End WC, SymPak II, Mar-cof BP, Mesehist WC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, Niva-Hist DM, Nalex AC, Dicel CD, BPM DM PHEN, Lodrane 24, Dristan Cold Maximum Strength, P-Tex, J-Tan PD, Tanacof-XR, Prop-A-Tane, Veltane, Histaject, Codimal A, Cophene B, B-Vex, LoHist-12, VaZol, Lodrane 12 Hour, Brovex, Trexbrom, J-Tan, Brovex CT, Nasahist B, ND-Stat, Dimetane Extentab, Siltane, Respa BR, Bidhist, Lodrane XR, Trexbrom (old formulation), V-COF, BetaTan, Vazotan, Pulmari, BroveX PB DM, Duravent DPB, Bromph DM, Neo DM Syrup, Poly Histine DM, DM Cold and Cough, Durahistine DM, EndaCof PD Drops, AccuHist DM Pediatric Drops, PediaHist DM, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Dallergy DM, Liquihistine DM, Myphetane DX, Bromanate DX Cough, Comtrex Acute Head Cold, Myphetane DX Cough, Liquiphed DM, Anaplex DM, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Carbofed DM Syrup, Uni-Hist DM Pediatric Drops, Bromhist-DM Drops, Pediahist DM Drops, Trihist DM, Uni Multihist DM, Alacol DM, Lohist-DM, BP Allergy DM, Y-COF DMX, TL-Hist DM, Tusdec-DM, Bromtuss DM, Dur-Tann DM, Tussi-Pres B, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Alahist DM, Balacall DM, Brotapp PE-DM, Glenmax PEB DM, KG Hist DM, Bromatan-DM, Glenmax PEB DM Forte, DuraTan DM, EndaCof-DM, AP-Hist DM, M-Hist DM, Relcof DM, Histinex DM, Prohistine DM, Poly DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, J-TanD PD
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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- Drug class: antihistamines