Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Resperal-DM, Bromaline, Dimetapp DM, Robitussin Allergy & Cough, Bromadine-DM, Bromfenex, Dimetapp Children's Cold & Cough, Rynex PE, Show all 287 »Bromphenex DM, Dime Time Extended Release, ENT, Siltane, Bromhist-PDX, Bromophed-DX, Lodrane 24D, Brotapp-DM, Carbofed DM Syrup, Vazotab, Ru-Hist D, Phenyl 7.5/6mg, Lodrane 12D, Brotapp, Histex SR, Dimetapp Elixir, Alacol, Brofed, Lodrane, Alenaze-D, Niva-Hist DM, Rynex DM, BroveX PB DM, Presgen B, Tussi-Pres B, Alahist DM, Brotapp PE-DM, Bromatan-DM, Bromph DM, Staflex, Alenaze-D NR, Nalex AC, Dimetane Extentab, Lodrane 24, VaZol, Cophene B, Vazotan, Veltane, Centussin DHC, Sildec DM, Carbodex DM Syrup, P-Hist DM Drops, Bromfenex PE Pediatric, Rhinabid PD, Bromfed-PD Capsules, BPM PE, B-Vex D, Bromaphedrine D, VaZol-D, Dimaphen Elixir, VazoBid, BroveX PB, Entre-B, Relhist BP, LoHist PEB, Poly-Tussin DHC, Bromfenex PE, EndaCof-DH, Drocon-CS, J-Tan D HC, SymTan A, Brovex HC, Endacof HC, J-Tan D, Bromcomp HC, Visvex, Bromph HD, Bromplex HD, Anaplex HD, M-END, Rhinabid, Canges-HC, VazoTuss HC, FluTuss HC, Canges-HC NR, BPM PE HC, VasoTuss HC, Tusnel-HC, Ala-Hist D, Ala-Hist, J-Cof DHC, BroveX-D, Vazobid-PD, Dimetane Decongestant, Touro Allergy, Lodrane LD, Nalfed PD, Respahist, Iofed PD, Ultrabrom PD, Pseubrom-PD, Bromfenex PD, M-Hist TD, Ultrabrom, Iofed, Pseubrom, Lodrane Liquid, Nalfed, Andehist NR Syrup, Allent, Bromaxefed RF Syrup, Sildec, Q-Tapp, Bromhist Pediatric Drops, AccuHist Pediatric, Unit-Tex 10/120 ER, Unit-Hist Drops, Di-Bromm, Bromhist-NR, Brovex SR, Dimaphen, LoHist-PD, LoHist-12D, Shellcap PD, Shellcap, BroveX ADT, Brom Tann, BroveX PEB, Zotex-PE, V-HIST, Dimetapp Children's Cold & Allergy, Phenyl 15/12mg, J-Tan D SR, Brom Tann PE, Brohist D, Decon-A, RespaHist II, Brotapp PE, Tanabid SR, Seradex-LA, Dibrom, Touro A&H, Altatapp, Myphetapp, LoHist PSB, Bromfed PD, Bromfed SR, Bidhist-D, Rynex PSE, Lodrane D, BroveX PSE, BroveX PD, BroveX PSB, B-Vex PD, Bromhist Pediatric, Endafed, ProHist DM, Brometane DX, Histacol BD Drops, Rydex, BroveX PB CX, TL-Hist CD, Poly-Tussin AC, M-End PE, Dimetane DC, Myphetane DC, Poly-Histine CS, Trihist-CS, Liquihistine CS, Poly CS, Polytine CS, M-End WC, Mar-cof BP, Mesehist WC, EndaCof-AC, AccuHist PDX Syrup, Uni-Hist PDX Syrup, Allanhist PDX Syrup, EndaCof-PD, Acutuss DM Pediatric, Uni-Hist DM Pediatric Syrup, AccuHist DM Pediatric Syrup, Bromhist-DM, Pediahist DM Syrup, Histacol DM Pediatric Syrup, BPM DM PHEN, Duravent DPB, Alacol DM, BroveX PB C, BroveX CBX, Y-COF DMX, J-Tan, Dristan Cold Maximum Strength, P-Tex, Bromaphen, J-Tan PD, Bromax, Tanacof-XR, Prop-A-Tane, Histaject, Codimal A, B-Vex, LoHist-12, Lodrane 12 Hour, Brovex, Brovex CT, BroveX CB, Nasahist B, ND-Stat, Dimetapp Allergy, Respa BR, Bidhist, Lodrane XR, Trexbrom (old formulation), V-COF, BetaTan, Pulmari, Seradex, Trexbrom, Dicel CD, SymPak II, BP Allergy DM, TL-Hist DM, Allanhist PDX Drops, Myphetane DX Cough, BroveX PSE DM Tablets, BroveX PSE DM, PBM Allergy, BroveX PSB DM, Anaplex DMX, BromTann/DM Tann/PSE Tann, Bromdex D, Neo DM Syrup, Dallergy DM, Dimetane DX, Myphetane DX, Bromanate DX Cough, Bromatane DX, Liquiphed DM, AccuHist DM Pediatric Drops, Comtrex Acute Head Cold, Anaplex DM, Andehist DM NR Syrup, Bromtapp-DM, Bromaxefed DM RF Syrup, PSE Brom DM, Bromaline DM, Uni-Hist DM Pediatric Drops, Bromplex DM, Bromhist-DM Drops, Pediahist DM Drops, Q-Tapp DM, Uni-Hist PDX Drops, PediaHist DM, EndaCof PD Drops, Tusdec-DM, AP-Hist DM, Bromtuss DM, Dur-Tann DM, Dimaphen DM, Cold & Cough Childrens, BroveX PEB DM, BPM PE DM, LoHist PEB DM, Balacall DM, Lohist-DM, Glenmax PEB DM, Glenmax PEB DM Forte, DuraTan DM, EndaCof-DM, M-Hist DM, Durahistine DM, Relcof DM, Histinex DM, Prohistine DM, Poly DM, Highland DM, Delhistine DM, Polytine DM, Iohist DM, KG Hist DM, Uni Multihist DM, Liquihistine DM, Trihist DM, Poly Histine DM, DM Cold and Cough, J-TanD PD
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Drug class: antihistamines