Brompheniramine use while Breastfeeding
Drugs containing Brompheniramine: Bromfed DM, Bromfed, Dimetapp Children's Cold & Cough, Resperal-DM, Brotapp-DM, Dimetapp Elixir, Robitussin Allergy & Cough, M-END, Brotapp, Bromaline, Show all 283 »Rynex DM, Dimetane DX, Canges-HC, BromTann/DM Tann/PSE Tann, Bromhist-PDX, Dimaphen DM, Alahist DM, Ru-Hist D, Dimetapp Children's Cold & Allergy, Carbofed DM Syrup, BroveX PSE DM Tablets, Anaplex DM, Poly-Tussin AC, Bromophed-DX, Andehist DM NR Syrup, Bromphenex DM, Dimaphen Elixir, Bromfenex, Alacol DM, DM Cold and Cough, Pseubrom, Alacol, Bromfed-PD Capsules, M-End WC, VazoBid, Bromaphedrine D, Brometane DX, Bromax, VasoTuss HC, ND-Stat, Siltane, Rhinabid, Dristan Cold Maximum Strength, Anaplex HD, Seradex, BetaTan, BroveX ADT, Vazotab, Sildec DM, Alenaze-D NR, BPM PE, B-Vex D, BroveX PEB, Carbodex DM Syrup, VaZol-D, Relhist BP, LoHist PEB, BroveX-D, Rynex PE, Dimetane Decongestant, BroveX PB, Entre-B, Rhinabid PD, J-Tan D, EndaCof-DH, Visvex, Bromph HD, Bromplex HD, Drocon-CS, Bromcomp HC, Endacof HC, J-Tan D HC, SymTan A, Brovex HC, Zotex-PE, VazoTuss HC, FluTuss HC, Ala-Hist, J-Cof DHC, Poly-Tussin DHC, Centussin DHC, Ala-Hist D, Bromfenex PE, Canges-HC NR, BPM PE HC, Tusnel-HC, Bromfenex PE Pediatric, Brotapp PE, M-Hist TD, Histex SR, Bromfenex PD, Ultrabrom, Iofed, Nalfed, Lodrane Liquid, Pseubrom-PD, Ultrabrom PD, Shellcap PD, Allent, Lodrane LD, Nalfed PD, Iofed PD, Respahist, Touro Allergy, Andehist NR Syrup, Dimaphen, Brovex SR, Bromhist-NR, Lodrane 24D, LoHist-PD, J-TanD PD, LoHist-12D, Di-Bromm, Unit-Hist Drops, Sildec, Bromaxefed RF Syrup, Q-Tapp, Bromhist Pediatric Drops, Unit-Tex 10/120 ER, AccuHist Pediatric, Shellcap, Touro A&H, Seradex-LA, Tanabid SR, P-Hist DM Drops, Vazobid-PD, Dime Time Extended Release, ENT, Dibrom, RespaHist II, Decon-A, Phenyl 15/12mg, Phenyl 7.5/6mg, J-Tan D SR, Brom Tann PE, Alenaze-D, Brohist D, Altatapp, Myphetapp, BroveX PD, BroveX PSE, Lodrane D, BroveX PSB, B-Vex PD, Endafed, Bromhist Pediatric, Rynex PSE, Lodrane 12D, LoHist PSB, Lodrane, Brofed, Bromfed PD, Bidhist-D, Bromfed SR, V-HIST, Bromtapp-DM, Poly-Histine CS, Myphetane DC, Trihist-CS, Liquihistine CS, Polytine CS, Poly CS, Dimetane DC, M-End PE, BroveX CBX, BroveX CB, EndaCof-AC, BroveX PB C, TL-Hist CD, BroveX PB CX, Mar-cof BP, Rydex, Pediahist DM Syrup, Bromhist-DM, Histacol DM Pediatric Syrup, Niva-Hist DM, BPM DM PHEN, BroveX PB DM, AccuHist DM Pediatric Syrup, Uni-Hist DM Pediatric Syrup, AccuHist PDX Syrup, Mesehist WC, Uni-Hist PDX Syrup, Allanhist PDX Syrup, Acutuss DM Pediatric, EndaCof-PD, Nalex AC, SymPak II, Cophene B, Codimal A, B-Vex, LoHist-12, Lodrane 12 Hour, VaZol, Histaject, Veltane, P-Tex, Comtrex Acute Head Cold, Bromaphen, J-Tan PD, Prop-A-Tane, Tanacof-XR, Lodrane 24, Brovex, V-COF, Trexbrom (old formulation), Vazotan, Pulmari, Dicel CD, Trexbrom, Lodrane XR, Bidhist, Brovex CT, J-Tan, Nasahist B, Dimetapp Allergy, Respa BR, Dimetane Extentab, Duravent DPB, BP Allergy DM, Dallergy DM, Neo DM Syrup, Myphetane DX, Bromanate DX Cough, Myphetane DX Cough, Bromatane DX, Bromdex D, Anaplex DMX, AccuHist DM Pediatric Drops, EndaCof PD Drops, PediaHist DM, BroveX PSE DM, BroveX PSB DM, PBM Allergy, Liquiphed DM, Bromadine-DM, Bromph DM, Q-Tapp DM, Uni-Hist PDX Drops, Allanhist PDX Drops, Brom Tann, Histacol BD Drops, Pediahist DM Drops, Bromhist-DM Drops, Bromaxefed DM RF Syrup, Staflex, PSE Brom DM, Bromaline DM, Bromplex DM, Uni-Hist DM Pediatric Drops, Dimetapp DM, Durahistine DM, BPM PE DM, BroveX PEB DM, LoHist PEB DM, Balacall DM, Lohist-DM, Brotapp PE-DM, Cold & Cough Childrens, Tussi-Pres B, Y-COF DMX, Presgen B, TL-Hist DM, Tusdec-DM, Dur-Tann DM, Bromtuss DM, Bromatan-DM, DuraTan DM, KG Hist DM, Iohist DM, Uni Multihist DM, Liquihistine DM, Poly Histine DM, Trihist DM, Polytine DM, Delhistine DM, AP-Hist DM, EndaCof-DM, Histinex DM, Prohistine DM, Highland DM, Poly DM, ProHist DM
Brompheniramine Levels and Effects while Breastfeeding
Summary of Use during Lactation
Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
In one telephone follow-up study, mothers reported irritability and colicky symptoms in 10% of infants exposed to various antihistamines and drowsiness was reported in 1.6% of infants. None of the reactions required medical attention and none of the infants were exposed to brompheniramine or dexbrompheniramine.
Irritability and disturbed sleep were reported in an 11-week-old breastfed infant whose mother was taking a product containing dexbrompheniramine and etafedrine (d-isoephedrine). These side effects were possibly caused by dexbrompheniramine in breastmilk, but could have been caused by the etafedrine or both drugs.
Effects on Lactation and Breastmilk
Antihistamines in relatively high doses given by injection can decrease basal serum prolactin in nonlactating women and in early postpartum women. However, suckling-induced prolactin secretion is not affected by antihistamine pretreatment of postpartum mothers. Whether lower oral doses of brompheniramine have the same effect on serum prolactin or whether the effects on prolactin have any consequences on breastfeeding success have not been studied. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Alternate Drugs to Consider
1. Ito S, Blajchman A, Stephenson M et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993;168:1393-9. PMID: 8498418
2. Mortimer EA Jr. Drug toxicity from breast milk? Pediatrics. 1977;60:780-1. Letter. PMID: 917668
3. Messinis IE, Souvatzoglou A, Fais N et al. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985;8:143-6. PMID: 3928731
4. Pontiroli AE, De Castro e Silva E, Mazzoleni F et al. The effect of histamine and H1 and H2 receptors on prolactin and luteinizing hormone release in humans: sex differences and the role of stress. J Clin Endocrinol Metab. 1981;52:924-8. PMID: 7228996
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Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Drug class: antihistamines
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