Skip to Content

Brompheniramine Pregnancy and Breastfeeding Warnings

Brompheniramine is also known as: B-Vex, Bidhist, Bromaphen, Bromax, Brovex, Brovex CT, Codimal A, Cophene B, Dimetane Extentab, Dimetapp Allergy, Histaject, J-Tan, J-Tan PD, LoHist-12, Lodrane 12 Hour, Lodrane 24, ND-Stat, Nasahist B, P-Tex, Prop-A-Tane, Respa BR, Siltane, Tanacof-XR, VaZol, Veltane

Medically reviewed on April 2, 2018

Brompheniramine Pregnancy Warnings

Brompheniramine has been assigned to pregnancy category C by the FDA. Animal studies failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. The Collaborative Perinatal Project monitored 65 first trimester exposures to brompheniramine. Malformations were reported in 10 infants, a statistically significant association. In another 6509 live births, 172 mothers were exposed to Dimetapp (brompheniramine, phenylephrine and phenylpropanolamine). Five infants were born with congenital abnormalities resulting in a somewhat higher frequency than normal. Brompheniramine is only recommended for use during pregnancy when benefit outweigh risk.

See references

Brompheniramine Breastfeeding Warnings

There are no data on the excretion of brompheniramine into human milk. Many H1-antagonists are excreted in human milk and in general, these medications are not recommended for use during breast-feeding. Side effects in breast-feeding infants may manifest as irritability, disturbed sleeping patterns, drowsiness, hyperexcitability, or excessive crying. Due to the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or brompheniramine, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Aselton P, Jick H, Milunsky A, Hunter JR, Stergachis A "First-trimester drug use and congenital disorders." Obstet Gynecol 65 (1985): 451-5
  3. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297

References for breastfeeding information

  1. Roberts RJ, Blumer JL, Gorman RL, et al "American Academy of Pediatrics Committee on Drugs: Transfer of drugs and other chemicals into human milk." Pediatrics 84 (1989): 924-36
  2. "Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  3. Mortimer EA, Jr "Drug toxicity from breast milk? ." Pediatrics 60 (1977): 780-1

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide