Codeine / pseudoephedrine / pyrilamine Side Effects
For the Consumer
Applies to codeine / pseudoephedrine / pyrilamine: oral liquid
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Like other narcotic medications, codeine can slow your breathing. Death may occur if breathing becomes too weak.
A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.
Stop taking this medicine and call your doctor at once if you have:
noisy breathing, sighing, shallow breathing;
a slow heart rate or weak pulse;
nervousness, trouble sleeping;
severe constipation; or
little or no urination.
Serious side effects may be more likely in older adults and those who are overweight, malnourished, or debilitated.
Common side effects may include:
dizziness, drowsiness, tired feeling;
dry mouth, nose, or throat;
sleep problems (insomnia).
Side effects such as dry mouth, constipation, and confusion may be more likely in older adults.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to codeine/pseudoephedrine/pyrilamine: oral liquid
The most commonly occurring side effects include dry mouth, dizziness, sleepiness, and disturbed coordination.[Ref]
Frequency not reported: Confusion, restlessness, excitation, anxiety, nervousness, irritability, insomnia, euphoria, hysteria, hallucination
Frequency not reported: Dry mouth, dry throat, epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation
Frequency not reported: Sedation, sleepiness, dizziness, disturbed coordination, tremor, paresthesias, neuritis, convulsions, CNS depression
Frequency not reported: Blurred vision, diplopia
1. "Product Information. Codeine Sulfate (codeine)." Roxane Laboratories Inc, Columbus, OH.
2. "Product Information. Neo AC (codeine / pseudoephedrine / pyrilamine)." Laser Pharmaceuticals, Crown Point, IN.
3. American Geriatrics Society 2012 Beers Criteria Update Expert Panel "American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults." J Am Geriatr Soc 60 (2012): 616-31
Some side effects of codeine / pseudoephedrine / pyrilamine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about codeine/pseudoephedrine/pyrilamine
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- Drug class: upper respiratory combinations
Other brands: Neo AC
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