Celexa Side Effects
Generic name: citalopram
Medically reviewed by Drugs.com. Last updated on Oct 13, 2022.
Note: This document contains side effect information about citalopram. Some dosage forms listed on this page may not apply to the brand name Celexa.
Summary
Common side effects of Celexa include: drowsiness, ejaculatory disorder, nausea, insomnia, and diaphoresis. Other side effects include: suicidal tendencies, agitation, diarrhea, impotence, sinusitis, anxiety, confusion, exacerbation of depression, lack of concentration, tremor, vomiting, anorexia, and xerostomia. Continue reading for a comprehensive list of adverse effects.
Applies to citalopram: oral capsule, oral solution, oral tablet.
Warning
Oral route (Capsule; Tablet)
Suicidal Thoughts and BehaviorsAntidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors. Citalopram capsules and tablets are not approved for use in pediatric patients.
Oral route (Solution)
Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of citalopram hydrobromide or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Citalopram hydrobromide oral solution is not approved for use in pediatric patients.
Serious side effects of Celexa
Along with its needed effects, citalopram (the active ingredient contained in Celexa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking citalopram:
More common
- Change or problem with discharge of semen
Less common
- Agitation
- blurred vision
- confusion
- decreased interest in sexual intercourse
- fever
- inability to have or keep an erection
- increase in the frequency of urination or amount of urine produced
- lack of emotion
- loss in sexual ability, desire, drive, or performance
- loss of memory
- menstrual changes
- skin rash or itching
- trouble breathing
Rare
- Behavior change similar to drunkenness
- bleeding gums
- breast tenderness or enlargement or unusual secretion of milk (in females)
- chills
- delayed or inability to have an orgasm
- diarrhea
- difficulty with concentrating
- dizziness or fainting
- drowsiness
- increased hunger
- increased thirst
- irregular heartbeat
- lack of energy
- lethargy
- nosebleed
- overactive reflexes
- painful urination
- poor coordination
- purple or red spots on the skin
- rapid weight gain
- red or irritated eyes
- redness, tenderness, itching, burning, or peeling of the skin
- seizures
- shivering
- slow or irregular heartbeat (less than 50 beats per minute)
- sore throat
- stupor
- sweating
- swelling of the face, ankles, or hands
- talking or acting with excitement you cannot control
- trembling, shaking, or twitching
- trouble with holding or releasing urine
- unusual or sudden body or facial movements or postures
- unusual tiredness or weakness
Incidence not known
- Back or leg pains
- black, tarry stools
- blistering, peeling, or loosening of the skin
- bloating
- bloody stools
- chest pain or tightness
- confusion as to time, place, or person
- constipation
- cough
- darkened urine
- difficult or fast breathing
- difficulty with swallowing
- drooling
- fast, slow, or irregular heartbeat
- general body swelling
- hive-like swelling on the face, eyelids, lips, tongue, or throat
- hives, itching
- holding false beliefs that cannot be changed by fact
- impaired consciousness, ranging from confusion to coma
- indigestion
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- loss of bladder control
- loss of consciousness
- muscle cramps, spasms, tightness, twitching, or jerking
- painful or prolonged erection of the penis
- pale skin
- penile erections, frequent or continuing
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- recurrent fainting
- red skin lesions, often with a purple center
- rhythmic movement of the muscles
- seeing, hearing, or feeling things that are not there
- sores, ulcers, or white spots in the mouth or on the lips
- stomach pain
- swelling of the breasts or unusual milk production
- tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
- total body jerking
- twitching, twisting, uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
- uncontrolled jerking or twisting movements
- unusual excitement
- vomiting of blood or material that looks like coffee grounds
- yellowing of the eyes or skin
Other side effects of Celexa
Some side effects of citalopram may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Decrease in sexual desire or ability
- sleepiness or unusual drowsiness
Less common
- Body aches or pain
- change in sense of taste
- continuing ringing or buzzing or other unexplained noise in the ears
- gas
- headache (severe and throbbing)
- hearing loss
- heartburn
- increased sweating
- increased yawning
- loss of voice
- loss or thinning of the hair
- sneezing
- stuffy or runny nose
- tingling, burning, or prickly feelings on the skin
- tooth grinding
- unusual increase or decrease in weight
- watering of the mouth
Rare
- Increased hair growth on the forehead, back, arms, and legs
- tanning or blue-gray discoloration of the skin
Incidence not known
- Bruising
- inability to sit still
- large, flat, blue or purplish patches in the skin
- need to keep moving
- uncontrolled eye movements
For Healthcare Professionals
Applies to citalopram: oral capsule, oral solution, oral tablet.
General
The side effects observed with citalopram (the active ingredient contained in Celexa) in clinical trials were generally reported as mild and transient, occurring most frequently in the first 1 to 2 weeks of therapy, and attenuating subsequently. The most commonly reported side effects were nausea, somnolence, dry mouth, increased sweating, tremor, diarrhea, and ejaculation disorder.[Ref]
Nervous system
Very common (10% or more): Headache (up to 26.9%), somnolence (up to 17.9%), dizziness (up to 10.3%)
Common (1% to 10%): Amnesia, extrapyramidal disorder, migraine, paresthesia, tremor,
Uncommon (0.1% to 1%): Abnormal gait, ataxia, cerebrovascular accident, convulsions, dystonia, hypoesthesia, involuntary muscle contractions, neuralgia, speech disorder, syncope, hyperkinesia, hypertonia, hypokinesia, dyskinesia, vertigo, transient ischemic attack
Rare (less than 0.1%): Abnormal coordination, dyskinesia, grand mal convulsion, hyperesthesia, stupor
Frequency not reported: Akathisia, movement disorder, serotonin syndrome
Postmarketing reports: Choreoathetosis, myoclonus, neuroleptic malignant syndrome, nystagmus[Ref]
Potentially life-threatening serotonin syndrome has been reported with SSRIs and SNRIs as monotherapy, but particularly with concomitant use of other serotonergic drugs and drugs that impair the metabolism of serotonin.[Ref]
Gastrointestinal
Very common (10% or more): Nausea (up to 21.4%), dry mouth (up to 20%)
Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, increased saliva, taste loss/perversion, vomiting
Uncommon (0.1% to 1%): Abnormal bleeding (predominantly of the mucous membranes), dysphagia, eructation, esophagitis, gastrointestinal bleeding, gastritis, gastroenteritis, gingivitis, hemorrhoids, stomatitis, teeth grinding
Rare (less than 0.1%): Colitis, diverticulitis, duodenal ulcer, gastric ulcer, gastroesophageal reflux, gingival bleeding, glossitis, rectal hemorrhage
Frequency not reported: Gastrointestinal hemorrhage
Postmarketing reports: Pancreatitis[Ref]
Psychiatric
Very common (10% or more): Insomnia (up to 18.8%)
Common (1% to 10%): Abnormal dreams, aggravated depression, agitation, anxiety, apathy, confusion, depression, impaired concentration, nervousness, suicide attempt, sleep disorder
Uncommon (0.1% to 1%): Aggressive reaction, delusion, depersonalization, drug dependence, emotional lability, euphoria, hallucination, mania, panic reaction, paranoid reaction, paroniria, psychosis, psychotic depression
Rare (less than 0.1%): Catatonic reaction, melancholia, suicide-related events
Frequency not reported: Bruxism, restlessness, panic attack, suicidal ideation/behavior
Postmarketing reports: Delirium, withdrawal syndrome[Ref]
Other
Very common (10% or more): Asthenia (up to 11.5%)
Common (1% to 10%): Fatigue, fever/pyrexia, tinnitus, asthenia
Rare (less than 0.1%): Facial edema, malaise, rigors
Postmarketing reports: Spontaneous abortion[Ref]
Dermatologic
Very common (10% or more): Increased sweating (up to 11.3%)
Common (1% to 10%): Rash, pruritus
Uncommon (0.1% to 1%): Abnormal bleeding of the skin, acne, alopecia, dermatitis, dry skin, eczema, flushing, photosensitivity reaction, psoriasis, purpura, skin discoloration, urticaria
Rare (less than 0.1%): Decreased sweating, cellulitis, hypertrichosis, keratitis, melanosis, pruritus ani
Frequency not reported: Angioedema, ecchymosis
Postmarketing reports: Epidermal necrolysis, erythema multiforme[Ref]
Genitourinary
Common (1% to 10%): Abnormal orgasm/anorgasmia (female), amenorrhea, decreased libido, dysmenorrhea, ejaculation disorders/ejaculation delay, impotence, menstrual disorders, polyuria, ejaculation failure, micturition disorders
Uncommon (0.1% to 1%): Breast enlargement, breast pain, dysuria, galactorrhea, increased libido, menorrhagia, micturition frequency, nonpuerperal lactation, vaginal bleeding, vaginal hemorrhage, urinary incontinence, urinary retention
Rare (less than 0.1%): Hematuria, oliguria
Frequency not reported: Metrorrhagia, priapism[Ref]
Urinary retention and galactorrhea have been reported with other SSRIs.
The estimates of the incidence of untoward sexual experience and performance may underestimate their actual incidence, partly because patients and physicians may be reluctant to discuss this issue. In placebo-controlled clinical trials, ejaculation disorder (primarily ejaculation delay) was reported as a treatment-emergent side effect at an incidence of 6% and at least twice the incidence in placebo-treated male patients.[Ref]
Respiratory
Common (1% to 10%): Coughing, pharyngitis, rhinitis, sinusitis, upper respiratory tract infection, yawning
Uncommon (0.1% to 1%): Bronchitis, dyspnea, epistaxis, pneumonia
Rare (less than 0.1%): Asthma, bronchospasm, hiccups, increased sputum, laryngitis, pneumonitis, pulmonary embolism[Ref]
Cardiovascular
Common (1% to 10%): Chest pain, hypotension, palpitations, postural hypotension, tachycardia
Uncommon (0.1% to 1%): Angina pectoris, atrial fibrillation, bradycardia, cardiac failure, edema (extremities), extrasystoles, hematomas, hot flushes, hypertension, myocardial infarction, myocardial ischemia
Rare (less than 0.1%): Bundle branch block, cardiac arrest, phlebitis, QT prolongation, torsades de pointes
Frequency not reported: Ventricular arrhythmia, orthostatic hypotension
Postmarketing reports: Thrombosis[Ref]
This drug has been associated with a dose-related QT-interval prolongation; there have been reports of QT-interval prolongation and ventricular arrhythmia, including torsade de pointes, particularly in females, patients with hypokalemia, or with pre-existing QT-interval prolongation, or other cardiac disease.[Ref]
Musculoskeletal
Epidemiological studies, primarily in patients aged 50 years or older, have shown an increased risk of bone fractures in patients receiving SSRIs or TCAs.[Ref]
Common (1% to 10%): Arthralgia, back pain, myalgia
Uncommon (0.1% to 1%): Arthritis, leg cramps, muscle weakness, skeletal pain
Rare (less than 0.1%): Bursitis, osteoporosis
Postmarketing reports: Rhabdomyolysis[Ref]
Metabolic
Common (1% to 10%): Anorexia, decreased/increased weight, decreased/increased appetite
Uncommon (0.1% to 1%): Abnormal glucose tolerance, thirst
Rare (less than 0.1%): Alcohol intolerance, dehydration, hypokalemia, hyponatremia, hypoglycemia, obesity[Ref]
Ocular
Common (1% to 10%): Abnormal accommodation
Uncommon (0.1% to 1%): Abnormal vision, conjunctivitis, dry eyes, eye pain, mydriasis
Rare (less than 0.1%): Abnormal lacrimation, cataract, diplopia, photophobia, ptosis
Frequency not reported: Visual disturbance, acute narrow angle glaucoma
Postmarketing reports: Angle-closure glaucoma[Ref]
Hepatic
Common (1% to 10%): Increased alkaline phosphatase
Uncommon (0.1% to 1%): Increased ALT, GGT, and AST
Rare (less than 0.1%): Bilirubinemia, cholelithiasis, cholecystitis, hepatitis, jaundice
Frequency not reported: Abnormal liver function test
Postmarketing reports: Cholestatic hepatitis, hepatic necrosis[Ref]
Immunologic
Common (1% to 10%): Influenza-like symptoms
Rare (less than 0.1%): Hay fever[Ref]
Hematologic
Uncommon (0.1% to 1%): Anemia, leukopenia, leukocytosis, lymphadenopathy
Rare (less than 0.1%): Coagulation disorder, granulocytopenia, hemorrhage, hypochromic anemia, lymphocytosis, lymphopenia
Frequency not reported: Thrombocytopenia
Postmarketing reports: Decreased prothrombin, hemolytic anemia[Ref]
Endocrine
Rare (less than 0.1%): Goiter, hypothyroidism
Frequency not reported: Inappropriate ADH secretion
Postmarketing reports: Prolactinemia[Ref]
Renal
Rare (less than 0.1%): Pyelonephritis, renal calculus, renal pain
Postmarketing reports: Acute renal failure[Ref]
Hypersensitivity
Frequency not reported: Anaphylactic reaction, hypersensitivity not otherwise specified
Postmarketing reports: Allergic reaction[Ref]
Frequently asked questions
- SSRI’s vs SNRI’s - What's the difference between them?
- What is the difference between Celexa and Lexapro?
- What are some common side effects of antidepressants?
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References
1. "Product Information. Celexa (citalopram)." Forest Pharmaceuticals (2001):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.