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Capreomycin Side Effects

For the Consumer

Applies to capreomycin: injection powder for solution

In addition to its needed effects, some unwanted effects may be caused by capreomycin. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking capreomycin, check with your doctor or nurse immediately:

More common:
  • Black, tarry stools
  • blood in the urine
  • change in the frequency of urination or amount of urine
  • chest pain
  • chills
  • cough
  • difficult breathing
  • dizziness
  • drowsiness
  • feeling of fullness in the ears
  • fever
  • increased thirst
  • loss of appetite
  • loss of balance
  • loss of hearing
  • nausea or vomiting
  • painful or difficult urination
  • ringing or buzzing in the ears
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the feet or lower legs
  • swollen glands
  • trouble with hearing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Rare
  • Bleeding gums
  • pinpoint red spots on the skin
Incidence not known:
  • Abdominal or stomach cramps
  • confusion
  • continuous ringing or buzzing or other unexplained noise in the ears
  • convulsions
  • decreased urine
  • dizziness or lightheadedness
  • dry mouth
  • feeling of constant movement of self or surroundings
  • irregular heartbeats
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle spasms (tetany) or twitching
  • numbness and tingling around the mouth, fingertips, or feet
  • sensation of spinning
  • tremor

Minor Side Effects

Some of the side effects that can occur with capreomycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Hives or welts, itching, or skin rash
  • pain, bleeding, or hard lump at the injection site
  • redness of the skin

For Healthcare Professionals

Applies to capreomycin: intramuscular powder for injection

Renal

Renal side effects have included dose-related nephrotoxicity, including BUN elevations (greater than 20 mg/dL) (36%), BUN elevations (greater than 30 mg/dL) (10%), depression of PSP excretion, abnormal urine sediment, renal insufficiency, and oliguria. At least one case of toxic nephritis and acute tubular necrosis has been reported.[Ref]

A patient with tuberculosis and portal cirrhosis experienced toxic nephritis and acute tubular necrosis coincident with capreomycin therapy. The patient was treated with capreomycin therapy (1 g) and aminosalicylic acid daily for 1 month. The patient developed renal insufficiency and oliguria and died. The autopsy showed subsiding acute tubular necrosis.[Ref]

Nervous system

Nervous system side effects have included ototoxicity and vestibular toxicity including subclinical auditory loss (11%), clinically apparent hearing loss (3%), vertigo, and tinnitus.[Ref]

Local

Local side effects have included pain, induration, and excessive bleeding at the injection site.[Ref]

Hematologic

Hematologic side effects have included leukocytosis, leukopenia, and eosinophilia. Thrombocytopenia has also been reported rarely.[Ref]

Hepatic

Hepatic side effects have included decreased BSP excretion.[Ref]

Metabolic

Metabolic side effects including hypokalemia, hypocalcemia, hypomagnesemia, and electrolyte disturbances resembling Bartter's syndrome have been reported.[Ref]

References

1. "Product Information. Capastat Sulfate (capreomycin)." Dura Pharmaceuticals, San Diego, CA.

Not all side effects for capreomycin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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