Belrapzo Side Effects
Generic name: bendamustine
Medically reviewed by Drugs.com. Last updated on Apr 13, 2021.
Note: This document contains side effect information about bendamustine. Some of the dosage forms listed on this page may not apply to the brand name Belrapzo.
For the Consumer
Applies to bendamustine: intravenous powder for solution, intravenous solution
Side effects requiring immediate medical attention
Along with its needed effects, bendamustine (the active ingredient contained in Belrapzo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking bendamustine:
- Black, tarry stools
- bleeding gums
- blood in the urine or stools
- chest pain
- cough or hoarseness
- joint pain, stiffness, or swelling
- lack or loss of strength
- lower back, side, or stomach pain
- muscle aches
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- sore throat
- stuffy or runny nose
- swelling of the feet or lower legs
- swollen glands
- trouble breathing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- unusual tiredness or weakness
- Burning or stinging of the skin
- chest tightness
- fast heartbeat
- hives, itching, or rash
- painful cold sores or blisters on the lips, nose, eyes, or genitals
- redness of the skin
- stiffness or swelling
- swelling of the eyelids, face, lips, hands, or feet
- trouble swallowing
Incidence not known
- Back pain
- blistering, flaking, or peeling of the skin
- bluish color
- blurred vision
- changes in skin color
- pain, tenderness, or swelling of the foot or leg
- pain or discomfort in the arms, jaw, back, or neck
- persistent non-healing sore
- pink growth
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- reddish patch or irritated area
- shiny bump
- thickening of bronchial secretions
- white, yellow, or waxy scar-like area
Side effects not requiring immediate medical attention
Some side effects of bendamustine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Decreased weight
For Healthcare Professionals
Applies to bendamustine: intravenous powder for injection, intravenous solution
Very common (10% or more): Decreased lymphocytes (up to 99%), decreased leukocytes (up to 94%), decreased hemoglobin (up to 89%), decreased neutrophils (up to 86%), decreased platelets (up to 86%), lymphocytopenia (up to 74%), neutropenia (up to 45%), thrombocytopenia (up to 39%), anemia (up to 38%), leukopenia (up to 37%)
Common (1% to 10%): Febrile neutropenia, hemorrhage, lymphopenia
Very rare (less than 0.01%): Hemolysis
Very common (10% or more): Nausea (up to 77%), diarrhea (up to 42%), vomiting (up to 40%), constipation (up to 31%), stomatitis (up to 21%), abdominal pain (up to 14%), dyspepsia (up to 14%), gastroesophageal reflux disease (up to 11%)
Very common (10% or more): Fatigue (up to 64%), infectious episodes (up to 37%), pyrexia (up to 36%), chills (up to 14%), asthenia (up to 13%), herpes zoster (up to 12%), mucosal inflammation
Uncommon (0.1% to 1%): Sepsis
Very rare (less than 0.01%): Infertility, multi-organ failure
Frequency not reported: Septic shock, general physical health deterioration
Postmarketing reports: Progressive multifocal leukoencephalopathy[Ref]
Very common (10% or more): Elevated bilirubin (up to 34%), increased creatinine, increased urea
Common (1% to 10%): Increased AST, increased ALT, increased alkaline phosphatase
Frequency not reported: Hepatitis, hepatic failure, gallbladder pain[Ref]
Very rare (less than 0.01%): Pulmonary fibrosis
Frequency not reported: Lung neoplasm, lung infiltration, pleural effusion
Postmarketing reports: Pneumocystis jiroveci pneumonia, pneumonitis[Ref]
Very common (10% or more): Headache (up to 21%), dizziness (up to 15%), dysgeusia (up to 11%)
Rare (less than 0.1%): Somnolence, aphonia
Very rare (less than 0.01%): Paresthesia, peripheral sensory neuropathy, anticholinergic syndrome, neurological disorders, ataxia, encephalitis
Rare (less than 0.1%): Dermatitis, macular-papular rash
Frequency not reported: Toxic skin reactions, bullous exanthema, urticaria
Postmarketing reports: Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms (DRESS), non-melanoma skin cancer (NMSC), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN)[Ref]
Very common (10% or more): Insomnia (up to 15%)
Very common (10% or more): Peripheral edema (up to 14%)
Uncommon (0.1% to 1%): Pericardial effusion
Rare (less than 0.1%): Myocardial infarction, acute circulatory failure, cardiac failure
Very rare (less than 0.01%): Phlebitis
Frequency not reported: Vasculitis
Very common (10% or more): Back pain (up to 14%)
Common (1% to 10%): Arthralgia, extremity pain, bone pain, myalgia
Frequency not reported: Sacral pain[Ref]
Very common (10% or more): Urinary tract infection (up to 11%)[Ref]
Common (1% to 10%): Hypersensitivity reactions
Rare (less than 0.1%): Anaphylaxis, anaphylactoid reaction
Common (1% to 10%): Infusion site pain, catheter site pain
Frequency not reported: Extravasation injury, infusion reactions, injection site reactions[Ref]
Frequency not reported: Retinal detachment[Ref]
Frequency not reported: Pre-malignant and malignant diseases/secondary tumors[Ref]
Frequency not reported: Acute renal failure[Ref]
Frequently asked questions
- Are lung nodules common after Bendeka & Rituxan therapy?
- Why has Bendeka replaced Treanda?
- How is Bendeka different to Treanda?
- How often is Bendeka given and how long does treatment last?
- Does Treanda cause hair loss?
- What is Treanda used for and how does it work?
- What is Bendeka used for?
More about Belrapzo (bendamustine)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: alkylating agents
Related treatment guides
1. "Product Information. Treanda (bendamustine)." Cephalon Inc, West Chester, PA.
2. Cerner Multum, Inc. "Australian Product Information." O 0
3. "Product Information. Bendeka (bendamustine)." Teva Pharmaceuticals USA, North Wales, PA.
4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.