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Aspirin / carisoprodol / codeine Side Effects

For the Consumer

Applies to aspirin/carisoprodol/codeine: oral tablet

Along with its needed effects, aspirin / carisoprodol / codeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin / carisoprodol / codeine:

More Common

Less Common

  • Cough
  • difficult or troubled breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • noisy breathing
  • shakiness and unsteady walk
  • tightness in the chest
  • unsteadiness, trembling, or other problems with muscle control or coordination

Incidence Not Known

  • Chills
  • cold sweats
  • confusion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • flushing or redness of the skin
  • hearing loss
  • hives, itching, skin rash
  • painful or difficult urination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusually warm skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking aspirin / carisoprodol / codeine:

Symptoms of Overdose

  • Agitation or combativeness
  • anxiety
  • black, tarry stools
  • bloody stools
  • blue lips and fingernails
  • change in consciousness
  • cold, clammy skin
  • confusion as to time, place, or person
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • decreased urination
  • depression
  • diarrhea
  • difficult, fast, or noisy breathing
  • difficulty with sleeping
  • disorientation
  • drowsiness to profound coma
  • dry mouth
  • expressed fear of impending death
  • extremely high fever or body temperature
  • fainting
  • fast or deep breathing
  • fast, weak pulse
  • headache
  • holding false beliefs that cannot be changed by fact
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • loss of strength or energy
  • mood or other mental changes
  • muscle cramps, pain, or weakness
  • nausea
  • pale or blue lips, fingernails, or skin
  • pale, clammy skin
  • pinpoint pupils
  • seeing, hearing, or feeling things that are not there
  • severe sleepiness
  • sunken eyes
  • sweating
  • swelling in the legs and ankles
  • thirst
  • unusual drowsiness, dullness, or feeling of sluggishness
  • unusual excitement, nervousness, or restlessness
  • vomiting
  • vomiting of blood or material that looks like coffee grounds
  • wrinkled skin

Some side effects of aspirin / carisoprodol / codeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • Drowsiness

Less Common

  • Feeling of constant movement of self or surroundings
  • sensation of spinning


  • Deep or fast breathing with dizziness
  • numbness of the feet, hands, and around the mouth
  • irritability
  • shaking
  • trouble sleeping

Incidence Not Known

  • Constipation
  • constricted, pinpoint, or small pupils (black part of the eye)
  • relaxed and calm feeling

For Healthcare Professionals

Applies to aspirin / carisoprodol / codeine: oral tablet



Frequency not reported: Nausea, vomiting, epigastric discomfort


Frequency not reported: Bleeding, perforation, obstruction of stomach, small intestine or large intestine, epigastric discomfort, gastric and duodenal ulcers, gastritis, gastrointestinal erosions, abdominal pain, heartburn, vomiting, nausea, anorexia


Frequency not reported: Nausea, vomiting, constipation[Ref]

Nervous system


Frequency not reported: Sedation, drowsiness, dizziness, ataxia, tremor

Postmarketing reports: Motor vehicle accidents, seizures


Frequency not reported: Intracranial hemorrhage


Frequency not reported: Sedation, dizziness[Ref]


Tinnitus may be a symptom of high serum salicylate levels.[Ref]


Frequency not reported: Vertigo


Frequency not reported: Tinnitus[Ref]



Frequency not reported: Tachycardia, postural hypotension, facial flushing, syncope


Frequency not reported: Hypotension[Ref]



Frequency not reported: Rash pruritus, purpura



Frequency not reported: Interstitial nephritis, acute renal failure[Ref]



Frequency not reported: Anaphylaxis, anaphylactoid reactions[Ref]



Frequency not reported: Elevated liver enzymes[Ref]


The most commonly reported adverse reactions may include nausea, dizziness, drowsiness, and gastrointestinal discomfort.[Ref]



Frequency not reported: Miosis[Ref]


Withdrawal symptoms that have been reported following abrupt withdrawal after prolonged use have included: insomnia, vomiting, abdominal cramps, headache, tremors, muscle twitching, ataxia, hallucinations, and psychosis.[Ref]

Frequency not reported: Drug dependence, withdrawal, abuse, misuse, criminal diversion, agitation, irritability, depressive reactions, insomnia[Ref]


1. "Product Information. ASA/Carisoprodol/Codeine Phosphate (aspirin / carisoprodol / codeine (ASA/carisoprodol/codeine))." Sandoz Laboratories, Eon Division, Lake Success, NY.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.