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Aspirin / carisoprodol / codeine Side Effects

For the Consumer

Applies to aspirin / carisoprodol / codeine: oral tablet

Along with its needed effects, aspirin / carisoprodol / codeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking aspirin / carisoprodol / codeine:

More common
  • Burning feeling in the chest or stomach
  • indigestion
  • stomach upset
  • tenderness in the stomach area
Less common
  • Cough
  • difficult or troubled breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • noisy breathing
  • shakiness and unsteady walk
  • tightness in the chest
  • unsteadiness, trembling, or other problems with muscle control or coordination
Incidence not known
  • Chills
  • cold sweats
  • confusion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • flushing or redness of the skin
  • hearing loss
  • hives
  • itching
  • painful or difficult urination
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusually warm skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking aspirin / carisoprodol / codeine:

Symptoms of overdose
  • Agitation or combativeness
  • anxiety
  • black, tarry stools
  • bloody stools
  • blue lips and fingernails
  • change in consciousness
  • cold, clammy skin
  • confusion
  • confusion as to time, place, or person
  • coughing that sometimes produces a pink frothy sputum
  • decreased awareness or responsiveness
  • decreased urination
  • depression
  • diarrhea
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • difficulty with sleeping
  • disorientation
  • drowsiness to profound coma
  • dry mouth
  • expressed fear of impending death
  • extremely high fever or body temperature
  • fainting
  • fast or deep breathing
  • fast, weak pulse
  • hallucinations
  • headache
  • holding false beliefs that cannot be changed by fact
  • irregular, fast or slow, or shallow breathing
  • lethargy
  • loss of consciousness
  • loss of strength or energy
  • mood or other mental changes
  • muscle cramps
  • muscle pain or weakness
  • nausea
  • pale or blue lips, fingernails, or skin
  • pale, clammy skin
  • pinpoint pupils
  • severe sleepiness
  • sunken eyes
  • sweating
  • swelling in the legs and ankles
  • thirst
  • unusual excitement, nervousness, or restlessness
  • vomiting
  • vomiting of blood or material that looks like coffee grounds
  • wrinkled skin

Some side effects of aspirin / carisoprodol / codeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Drowsiness
Less common
  • Feeling of constant movement of self or surroundings
  • sensation of spinning
Rare
  • Hyperventilation
  • irritability
  • shaking
  • trouble sleeping
Incidence not known
  • Constipation
  • constricted, pinpoint, or small pupils (black part of the eye)
  • relaxed and calm

For Healthcare Professionals

Applies to aspirin / carisoprodol / codeine: oral tablet

Gastrointestinal

Carisoprodol:
Frequency not reported: Nausea, vomiting, epigastric discomfort

Aspirin:
Frequency not reported: Bleeding, perforation, obstruction of stomach, small intestine or large intestine, epigastric discomfort, gastric and duodenal ulcers, gastritis, gastrointestinal erosions, abdominal pain, heartburn, vomiting, nausea, anorexia

Codeine:
Frequency not reported: Nausea, vomiting, constipation[Ref]

Nervous system

Carisoprodol:
Frequency not reported: Sedation, drowsiness, dizziness, ataxia, tremor
Postmarketing reports: Motor vehicle accidents, seizures

Aspirin:
Frequency not reported: Intracranial hemorrhage

Codeine:
Frequency not reported: Sedation, dizziness[Ref]

Other

Tinnitus may be a symptom of high serum salicylate levels.[Ref]

Carisoprodol:
Frequency not reported: Vertigo

Aspirin:
Frequency not reported: Tinnitus[Ref]

Cardiovascular

Carisoprodol:
Frequency not reported: Tachycardia, postural hypotension, facial flushing, syncope

Codeine:
Frequency not reported: Hypotension[Ref]

Dermatologic

Aspirin:
Frequency not reported: Rash pruritus, purpura

Renal

Aspirin:
Frequency not reported: Interstitial nephritis, acute renal failure[Ref]

Hypersensitivity

Aspirin
Frequency not reported: Anaphylaxis, anaphylactoid reactions[Ref]

Hepatic

Aspirin:
Frequency not reported: Elevated liver enzymes[Ref]

General

The most commonly reported adverse reactions may include nausea, dizziness, drowsiness, and gastrointestinal discomfort.[Ref]

Ocular

Codeine:
Frequency not reported: Miosis[Ref]

Psychiatric

Withdrawal symptoms that have been reported following abrupt withdrawal after prolonged use have included: insomnia, vomiting, abdominal cramps, headache, tremors, muscle twitching, ataxia, hallucinations, and psychosis.[Ref]

Frequency not reported: Drug dependence, withdrawal, abuse, misuse, criminal diversion, agitation, irritability, depressive reactions, insomnia[Ref]

References

1. "Product Information. ASA/Carisoprodol/Codeine Phosphate (aspirin / carisoprodol / codeine (ASA/carisoprodol/codeine))." Sandoz Laboratories, Eon Division, Lake Success, NY.

Some side effects of aspirin / carisoprodol / codeine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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