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Aspirin / Carisoprodol / Codeine Dosage

Applies to the following strength(s): 325 mg-200 mg-16 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Muscle Spasm

1 to 2 tablets 4 times a day
Maximum daily dose: carisoprodol: 1600 mg; aspirin: 2600 mg; codeine: 128 mg
Duration of therapy: Up to 2 or 3 weeks

Comments:
-Use should be limited to short periods (up to 3 weeks) since acute, painful musculoskeletal conditions are generally of short duration and evidence of effectiveness beyond this time period has not been established.

Use: For the relief of discomfort associated with acute, painful musculoskeletal conditions.

Usual Adult Dose for Pain

1 to 2 tablets 4 times a day
Maximum daily dose: carisoprodol: 1600 mg; aspirin: 2600 mg; codeine: 128 mg
Duration of therapy: Up to 2 or 3 weeks

Comments:
-Use should be limited to short periods (up to 3 weeks) since acute, painful musculoskeletal conditions are generally of short duration and evidence of effectiveness beyond this time period has not been established.

Use: For the relief of discomfort associated with acute, painful musculoskeletal conditions.

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Precautions

US BOXED WARNING: DEATH RELATED TO ULTRA-RAPID METABOLISM of CODEINE to MORPHINE:
-Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to CYP450 2D6 polymorphism.

Safety and efficacy have not been established in patients younger than 16 years or older than 65 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule: III

Dialysis

Data not available

Other Comments

Administration advice:
-Duration of therapy should be limited to short-term treatment

General:
-Dependence, withdrawal, and abuse have been reported; the risk of abuse should be assessed prior to prescribing.
-Treatment duration should not exceed up to 2 to 3 weeks; if musculoskeletal symptoms persist, patients should be re-evaluated.

Monitoring:
-Monitor for sedation
-Monitor for signs of abuse and overdose

Patient advice:
-Patients should understand that this product contains aspirin and that aspirin may cause a wide range of gastrointestinal adverse reactions including potentially fatal events; patients should be informed of signs or symptoms to watch for and which require prompt medical attention.
-Patients should be advised that this drug may cause drowsiness and dizziness and that there have been reports of motor vehicle accidents following use; patients should be advised to avoid hazardous activities such as driving while taking this drug.
-Patients should be advised to avoid concomitant use with alcohol and to check with their health care professional before taking other CNS depressants.
-Patients should understand that this drug has been associated with cases of dependence, withdrawal, and abuse; use should be limited to less than 3 weeks duration.
-Patients should understand the risks of life-threatening respiratory depression and when this risk is greatest; patients should be aware that a genetic mutation may result in greater toxicity in some patients.
-For women who are breastfeeding and have this genetic mutation, their infant will be at risk for morphine toxicity; nursing mothers should be instructed to seek immediate medical attention for infants experiencing increased sleepiness, difficulty breastfeeding, breathing difficulties, or limpness.
-Women of child bearing potential should understand that prolonged use during pregnancy can result in neonatal opioid withdrawal syndrome and that prompt recognition and treatment will be necessary.

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