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Angiotensin II Side Effects

Medically reviewed by Last updated on Jun 20, 2023.

Applies to angiotensin II: intravenous solution.

Serious side effects of Angiotensin II

Along with its needed effects, angiotensin II may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking angiotensin II:

More common

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • confusion as to time, place, or person
  • drowsiness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • nausea
  • pain in the arms, legs, or lower back, especially in the calves or heels upon exertion
  • pain, redness, or swelling in the arm or leg
  • pinpoint red spots on the skin
  • seeing, hearing, or feeling things that are not there
  • troubled breathing
  • unusual bleeding or bruising
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • vomiting

Less common

  • Blurred vision
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • itching of the skin
  • numbness and tingling of the face, fingers, or toes
  • pale, bluish-colored, or cold hands or feet
  • stomach pain
  • sweating
  • unexplained weight loss

Other side effects of Angiotensin II

Some side effects of angiotensin II may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Itching in the genitals or other skin areas
  • scaling

For Healthcare Professionals

Applies to angiotensin II: intravenous solution.


The most frequently reported side effects were thromboembolic events.[Ref]


Very common (10% or more): Thromboembolic events (12.9%)

Common (1% to 10%): Deep vein thrombosis, tachycardia, peripheral ischemia[Ref]


Common (1% to 10%): Thrombocytopenia[Ref]


Common (1% to 10%): Acidosis, hyperglycemia[Ref]


Common (1% to 10%): Delirium[Ref]


Common (1% to 10%): Fungal infection[Ref]


1. Product Information. Giapreza (angiotensin II). La Jolla Pharmaceutical. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.