Angiotensin Ii Dosage

Usual Adult Dose for Shock

Initial dose: 20 ng/kg/min via continuous IV infusion
Maintenance dose: Monitor blood pressure response and titrate every 5 minutes by increments of up to 15 ng/kg/min as needed to achieve or maintain target blood pressure; maintenance doses not to exceed 40 ng/kg/min
Maximum dose: Not to exceed 80 ng/kg/min during the first 3 hours of treatment

Comments:

• Doses as low as 1.25 ng/kg/min may be used.
• Once the underlying shock has sufficiently improved, down-titrate every 5 to 15 minutes by increments of up to 15 ng/kg/min based on blood pressure.

Use: For the increase of blood pressure in patients with septic or other distributive shock

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• For IV infusion only.
• A central venous line for administration is recommended.
• Inspect visually for particulate matter and discoloration prior to use.

Storage requirements:

• Vials: Store in the refrigerator at 2C to 8C (36F to 46F).
• Diluted solution: Discard after 24 hours at room temperature or under refrigeration.

Reconstitution/preparation techniques:

• Dilute in 0.9% sodium chloride prior to use.
• Dilute the contents of 1 vial of this drug in 0.9% saline to achieve a final concentration of 5000 ng/mL or 10,000 ng/mL
• Discard vial and any unused portion after use.
• The manufacturer product information should be consulted for appropriate information regarding preparation of diluted solutions.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer