Amoxicillin / Omeprazole / Rifabutin Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 18, 2024.

Applies to amoxicillin / omeprazole / rifabutin: oral capsule delayed release.

Precautions

It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, discuss this with your doctor.

Do not use this medicine together with delavirdine (Rescriptor®), rilpivirine ((Edurant®) or products containing rilpivirine (eg, Complera®, Odefsey®), or voriconazole (Vfend®). Using these medicines together may increase risk for more serious side effects.

Using this medicine while you are pregnant can harm your unborn baby. Use birth control pills together with another form of birth control (eg, condom, diaphragm, or contraceptive foam or jelly) to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have chest tightness, rash, itching, fast heartbeat, trouble breathing or swallowing, or large, hive-like swelling of the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs while you are using this medicine.

Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness. These may be symptoms of serious skin reactions, including Stevens-Johnson syndrome, acute generalized exanthematous pustulosis (AGEP), toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms (DRESS).

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you Stop taking amoxicillin / omeprazole / rifabutin. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Check with your doctor right away if you have a change in frequency of urination or amount of urine, blood in the urine, fever, joint pain, loss of appetite, skin rash, swelling of the body, feet, or ankles, unusual tiredness or weakness, or unusual weight gain after taking this medicine. These could be symptoms of acute tubulointerstitial nephritis.

Cutaneous or systemic lupus erythematosus may occur or get worse in patients receiving a PPI. Call your doctor right away if you have joint pain or a skin rash on your cheeks or arms that gets worse when exposed to the sun.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

Avoid taking this medicine with alcohol.

This medicine may cause your skin, tears, saliva, sweat, urine, or bowel movements to turn a brownish-orange color. Your contact lenses could become permanently discolored.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Other side effects

Some side effects of amoxicillin / omeprazole / rifabutin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects

Along with its needed effects, amoxicillin / omeprazole / rifabutin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / omeprazole / rifabutin:

For healthcare professionals

Applies to amoxicillin / omeprazole / rifabutin: oral delayed release capsule.

General adverse events

The most commonly reported side effects included headache, diarrhea, chromaturia, and rash.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 15.6%)
• Frequency not reported: Migraine

Amoxicillin:

• Postmarketing reports: Convulsions, dizziness

Omeprazole:

• Frequency not reported: Dizziness
• Postmarketing reports: Double vision, dream abnormalities, hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo

Rifabutin:

• Frequency not reported: Taste perversion^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 14.3%)
• Common (1% to 10%): Abdominal pain, dyspepsia, nausea
• Frequency not reported: Abdominal pain lower, abdominal pain upper, Clostridioides difficile-associated diarrhea, epigastric discomfort, oropharyngeal pain, vomiting

Amoxicillin:

• Postmarketing reports: Black hairy tongue

Omeprazole:

• Frequency not reported: Acid regurgitation, constipation, flatulence
• Postmarketing reports: Abdominal swelling, dry mouth, fatal pancreatitis, fecal discoloration, fundic gland polyps, irritable colon, microscopic colitis, mucosal atrophy of the tongue, pancreatitis, stomatitis

Rifabutin:

• Frequency not reported: Eructation, flatulence^[Ref]

Genitourinary

• Very common (10% or more): Chromaturia (up to 13%)
• Common (1% to 10%): Vulvovaginal candidiasis
• Frequency not reported: Vaginal discharge, vulvovaginal burning sensation, vulvovaginal mycotic infection, vulvovaginal pruritus

Amoxicillin:

• Postmarketing reports: Crystalluria

Omeprazole:

• Postmarketing reports: Glycosuria, hematuria, proteinuria, testicular pain, urinary frequency, urinary tract infection^[Ref]

Dermatologic

• Common (1% to 10%): Rash
• Frequency not reported: Maculopapular rash, morbilliform rash, urticaria

Amoxicillin:

• Postmarketing reports: Thrombocytopenic purpura

Omeprazole:

• Postmarketing reports: Alopecia, dry skin, hyperhidrosis, petechiae, photosensitivity, pruritus, purpura, urticaria

Rifabutin:

• Frequency not reported: Skin discoloration^[Ref]

Musculoskeletal

• Frequency not reported: Cutaneous lupus erythematosus, systemic lupus erythematosus

Omeprazole:

• Frequency not reported: Back pain
• Postmarketing reports: Bone fracture, joint pain, leg pain, muscle cramps, muscle weakness, myalgia

Rifabutin:

• Frequency not reported: Arthralgia, myalgia, myositis^[Ref]

Hematologic

Amoxicillin:

• Postmarketing reports: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia

Omeprazole:

• Postmarketing reports: Agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia

Rifabutin:

• Frequency not reported: Anemia, hemolysis, leukopenia, pancytopenia, thrombocytopenia
• Postmarketing reports: Agranulocytosis, lymphopenia^[Ref]

Other

Omeprazole:

• Frequency not reported: Asthenia
• Postmarketing reports: Tinnitus

Rifabutin:

• Frequency not reported: Asthenia, fever, flu-like syndrome, pain^[Ref]

Respiratory

• Frequency not reported: Nasal congestion, nasopharyngitis

Omeprazole:

• Frequency not reported: Cough, upper respiratory infection

Rifabutin:

• Frequency not reported: Dyspnea^[Ref]

Hepatic

Amoxicillin:

• Postmarketing reports: Acute cytolytic hepatitis, cholestasis, cholestatic jaundice, liver dysfunction

Omeprazole:

• Postmarketing reports: Cholestatic disease, fatal liver failure, fatal liver necrosis, hepatocellular disease, jaundice, mixed hepatitis

Rifabutin:

• Frequency not reported: Hepatitis, jaundice^[Ref]

Psychiatric

Amoxicillin:

• Postmarketing reports: Agitation, anxiety, behavioral changes, confusion, hyperactivity, insomnia

Omeprazole:

• Postmarketing reports: Aggression, agitation, anxiety, apathy, confusion, depression, hallucinations, insomnia, nervousness

Rifabutin:

• Frequency not reported: Insomnia^[Ref]

Cardiovascular

Omeprazole:

• Postmarketing reports: Angina, bradycardia, elevated blood pressure, epistaxis, palpitations, peripheral edema, tachycardia

Rifabutin:

• Frequency not reported: Chest pain^[Ref]

Metabolic

Omeprazole:

• Postmarketing reports: Anorexia, hypoglycemia, hypomagnesemia with/without hypocalcemia and/or hypokalemia, hyponatremia, weight gain

Rifabutin:

• Frequency not reported: Anorexia^[Ref]

Ocular

• Frequency not reported: Uveitis

Omeprazole:

• Postmarketing reports: Blurred vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis^[Ref]

Immunologic

• Frequency not reported: Fungal infection

Omeprazole:

• Postmarketing reports: Microscopic pyuria^[Ref]

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions^[Ref]

Oncologic

Omeprazole:

• Postmarketing reports: Gastroduodenal carcinoids^[Ref]

Gastroduodenal carcinoids occurred as a manifestation of Zollinger-Ellison syndrome in patients who received long-term treatment; this condition is a manifestation of the underlying condition.^[Ref]

Endocrine

Omeprazole:

• Postmarketing reports: Gynecomastia^[Ref]

Renal

• Frequency not reported: Acute interstitial nephritis

Omeprazole:

• Postmarketing reports: Elevated serum creatinine^[Ref]

See also:

Further information

Amoxicillin/omeprazole/rifabutin side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer