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Amoxicillin / omeprazole / rifabutin Side Effects

Medically reviewed by Drugs.com. Last updated on Sep 20, 2020.

For the Consumer

Applies to amoxicillin/omeprazole/rifabutin: oral capsule delayed release

Side effects requiring immediate medical attention

Along with its needed effects, amoxicillin / omeprazole / rifabutin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amoxicillin / omeprazole / rifabutin:

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blistering, peeling, loosening of the skin
  • blood in the urine or stools
  • blurred vision or other change in vision
  • chills
  • cloudy urine
  • confusion
  • cough
  • cracks in the skin
  • diarrhea
  • difficulty in moving
  • difficulty with swallowing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • eye pain
  • fast heartbeat
  • fever
  • greatly decreased frequency of urination or amount of urine
  • hives, itching, or skin rash
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of heat from the body
  • muscle aches, cramps, pains, or stiffness
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red, irritated eyes
  • red skin lesions, often with a purple center
  • red, swollen skin
  • scaly skin
  • sensitivity of the eye to light
  • severe stomach cramps and pain
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • stomach tenderness
  • sweating
  • swelling of the breasts or breast soreness in both females and males
  • swelling of the feet or lower legs
  • tearing
  • tightness in the chest
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery and severe diarrhea, which may also be bloody

Side effects not requiring immediate medical attention

Some side effects of amoxicillin / omeprazole / rifabutin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • change or loss of taste
  • difficulty having a bowel movement (stool)
  • heartburn
  • indigestion
  • loss of appetite
  • stomach discomfort or upset
  • trouble sleeping

For Healthcare Professionals

Applies to amoxicillin / omeprazole / rifabutin: oral delayed release capsule

General

The most commonly reported side effects included headache, diarrhea, chromaturia, and rash.[Ref]

Nervous system

Very common (10% or more): Headache (up to 15.6%)

Frequency not reported: Migraine

Amoxicillin:

Postmarketing reports: Convulsions, dizziness

Omeprazole:

Frequency not reported: Dizziness

Postmarketing reports: Double vision, dream abnormalities, hepatic encephalopathy, paresthesia, somnolence, taste perversion, tremors, vertigo

Rifabutin:

Frequency not reported: Taste perversion[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 14.3%)

Common (1% to 10%): Abdominal pain, dyspepsia, nausea

Frequency not reported: Abdominal pain lower, abdominal pain upper, Clostridioides difficile-associated diarrhea, epigastric discomfort, oropharyngeal pain, vomiting

Amoxicillin:

Postmarketing reports: Black hairy tongue

Omeprazole:

Frequency not reported: Acid regurgitation, constipation, flatulence

Postmarketing reports: Abdominal swelling, dry mouth, fatal pancreatitis, fecal discoloration, fundic gland polyps, irritable colon, microscopic colitis, mucosal atrophy of the tongue, pancreatitis, stomatitis

Rifabutin:

Frequency not reported: Eructation, flatulence[Ref]

Genitourinary

Very common (10% or more): Chromaturia (up to 13%)

Common (1% to 10%): Vulvovaginal candidiasis

Frequency not reported: Vaginal discharge, vulvovaginal burning sensation, vulvovaginal mycotic infection, vulvovaginal pruritus

Amoxicillin:

Postmarketing reports: Crystalluria

Omeprazole:

Postmarketing reports: Glycosuria, hematuria, proteinuria, testicular pain, urinary frequency, urinary tract infection[Ref]

Dermatologic

Common (1% to 10%): Rash

Frequency not reported: Maculopapular rash, morbilliform rash, urticaria

Amoxicillin:

Postmarketing reports: Thrombocytopenic purpura

Omeprazole:

Postmarketing reports: Alopecia, dry skin, hyperhidrosis, petechiae, photosensitivity, pruritus, purpura, urticaria

Rifabutin:

Frequency not reported: Skin discoloration[Ref]

Musculoskeletal

Frequency not reported: Cutaneous lupus erythematosus, systemic lupus erythematosus

Omeprazole:

Frequency not reported: Back pain

Postmarketing reports: Bone fracture, joint pain, leg pain, muscle cramps, muscle weakness, myalgia

Rifabutin:

Frequency not reported: Arthralgia, myalgia, myositis[Ref]

Hematologic

Amoxicillin:

Postmarketing reports: Agranulocytosis, anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia

Omeprazole:

Postmarketing reports: Agranulocytosis, anemia, hemolytic anemia, leukocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia

Rifabutin:

Frequency not reported: Anemia, hemolysis, leukopenia, pancytopenia, thrombocytopenia

Postmarketing reports: Agranulocytosis, lymphopenia[Ref]

Other

Omeprazole:

Frequency not reported: Asthenia

Postmarketing reports: Tinnitus

Rifabutin:

Frequency not reported: Asthenia, fever, flu-like syndrome, pain[Ref]

Respiratory

Frequency not reported: Nasal congestion, nasopharyngitis

Omeprazole:

Frequency not reported: Cough, upper respiratory infection

Rifabutin:

Frequency not reported: Dyspnea[Ref]

Hepatic

Amoxicillin:

Postmarketing reports: Acute cytolytic hepatitis, cholestasis, cholestatic jaundice, liver dysfunction

Omeprazole:

Postmarketing reports: Cholestatic disease, fatal liver failure, fatal liver necrosis, hepatocellular disease, jaundice, mixed hepatitis

Rifabutin:

Frequency not reported: Hepatitis, jaundice[Ref]

Psychiatric

Amoxicillin:

Postmarketing reports: Agitation, anxiety, behavioral changes, confusion, hyperactivity, insomnia

Omeprazole:

Postmarketing reports: Aggression, agitation, anxiety, apathy, confusion, depression, hallucinations, insomnia, nervousness

Rifabutin:

Frequency not reported: Insomnia[Ref]

Cardiovascular

Omeprazole:

Postmarketing reports: Angina, bradycardia, elevated blood pressure, epistaxis, palpitations, peripheral edema, tachycardia

Rifabutin:

Frequency not reported: Chest pain[Ref]

Metabolic

Omeprazole:

Postmarketing reports: Anorexia, hypoglycemia, hypomagnesemia with/without hypocalcemia and/or hypokalemia, hyponatremia, weight gain

Rifabutin:

Frequency not reported: Anorexia[Ref]

Ocular

Frequency not reported: Uveitis

Omeprazole:

Postmarketing reports: Blurred vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis[Ref]

Immunologic

Frequency not reported: Fungal infection

Omeprazole:

Postmarketing reports: Microscopic pyuria[Ref]

Hypersensitivity

Frequency not reported: Hypersensitivity reactions[Ref]

Oncologic

Gastroduodenal carcinoids occurred as a manifestation of Zollinger-Ellison syndrome in patients who received long-term treatment; this condition is a manifestation of the underlying condition.[Ref]

Omeprazole:

Postmarketing reports: Gastroduodenal carcinoids[Ref]

Endocrine

Omeprazole:

Postmarketing reports: Gynecomastia[Ref]

Renal

Frequency not reported: Acute interstitial nephritis

Omeprazole:

Postmarketing reports: Elevated serum creatinine[Ref]

References

1. "Product Information. Talicia (amoxicillin / omeprazole / rifabutin)." RedHill Biopharma Inc., Raleigh, NC.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.