Amoxicillin / Omeprazole / Rifabutin Dosage

Medically reviewed by Drugs.com. Last updated on Feb 11, 2025.

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 250 mg-omeprazole 10 mg-rifabutin 12.5 mg oral capsules: 4 capsules orally every 8 hours

• Duration of therapy: 14 days

Comments:

• Capsules should be swallowed with at least 8 ounces of water.
• This drug should be used to treat infections proven/strongly suspected to be caused by susceptible bacteria.
• Antibiotic selection should be determined by local bacterial resistance, duration of treatment, and appropriate use.

Use: Treatment of Helicobacter pylori infection

Renal Dose Adjustments

Mild to moderate renal dysfunction (Glomerular filtration rate [GFR] greater than 30 mL/min): Data not available
Severe renal dysfunction (GFR less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Liver dysfunction (Child-Pugh Class A, B, and C): Not recommended.

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to all the active components, any other rifamycins, other benzimidazoles (e.g., anthelmintics, proton pump inhibitors [PPIs]), other beta-lactam antibacterial drugs (e.g., cephalosporins, penicillins) or to any of the ingredients
• Patients receiving delavirdine, rilpivirine-containing products, and/or voriconazole

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug should be taken with meals.
• Capsules should be swallowed whole, without crushing/chewing.
• If patients miss a dose, the normal dosing schedule should be continued until this regimen is completed; patients should not take 2 doses to make up for the missed dose.

Storage requirements:

• Protect from light and moisture.

General:

• Alcohol should be avoided during treatment.
• Antacids may be taken with treatment.

Monitoring:

• HYPERSENSITIVITY: Signs/symptoms of hypersensitivity reactions
• METABOLIC: Blood glucose (in patients at risk of hypoglycemia)
• OCULAR: Signs/symptoms of uveitis (when used with macrolides or triazole antifungal agents)

Patient advice:

• Patients should be advised to avoid missing doses and to complete the entire course of therapy.
• Patients should be warned that treatment may produce a discoloration of sputum, sweat, tears, teeth, and urine; soft contact lenses may be permanently stained.
• Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, acute interstitial nephritis, or systemic cutaneous lupus erythematosus occur.
• Patients should be instructed to report signs/symptoms of Clostridium difficile (e.g., watery/bloody stools, stomach cramps, fever), for up to 2 months after stopping treatment.
• Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer