Amoxicillin / Omeprazole / Rifabutin Dosage
Medically reviewed by Drugs.com. Last updated on Feb 13, 2023.
Applies to the following strengths: 250 mg-10 mg-12.5 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Helicobacter pylori Infection
Amoxicillin 250 mg-omeprazole 10 mg-rifabutin 12.5 mg oral capsules: 4 capsules orally every 8 hours
- Duration of therapy: 14 days
- Capsules should be swallowed with at least 8 ounces of water.
- This drug should be used to treat infections proven/strongly suspected to be caused by susceptible bacteria.
- Antibiotic selection should be determined by local bacterial resistance, duration of treatment, and appropriate use.
Use: Treatment of Helicobacter pylori infection
Renal Dose Adjustments
Mild to moderate renal dysfunction (Glomerular filtration rate [GFR] greater than 30 mL/min): Data not available
Severe renal dysfunction (GFR less than 30 mL/min): Not recommended.
Liver Dose Adjustments
Liver dysfunction (Child-Pugh Class A, B, and C): Not recommended.
- Hypersensitivity to all the active components, any other rifamycins, other benzimidazoles (e.g., anthelmintics, proton pump inhibitors [PPIs]), other beta-lactam antibacterial drugs (e.g., cephalosporins, penicillins) or to any of the ingredients
- Patients receiving delavirdine, rilpivirine-containing products, and/or voriconazole
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
- This drug should be taken with meals.
- Capsules should be swallowed whole, without crushing/chewing.
- If patients miss a dose, the normal dosing schedule should be continued until this regimen is completed; patients should not take 2 doses to make up for the missed dose.
- Protect from light and moisture.
- Alcohol should be avoided during treatment.
- Antacids may be taken with treatment.
- HYPERSENSITIVITY: Signs/symptoms of hypersensitivity reactions
- METABOLIC: Blood glucose (in patients at risk of hypoglycemia)
- OCULAR: Signs/symptoms of uveitis (when used with macrolides or triazole antifungal agents)
- Patients should be advised to avoid missing doses and to complete the entire course of therapy.
- Patients should be warned that treatment may produce a discoloration of sputum, sweat, tears, teeth, and urine; soft contact lenses may be permanently stained.
- Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, acute interstitial nephritis, or systemic cutaneous lupus erythematosus occur.
- Patients should be instructed to report signs/symptoms of Clostridium difficile (e.g., watery/bloody stools, stomach cramps, fever), for up to 2 months after stopping treatment.
- Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.
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- Drug class: H. pylori eradication agents
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