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Amoxicillin / Omeprazole / Rifabutin Dosage

Medically reviewed by Last updated on Feb 13, 2023.

Applies to the following strengths: 250 mg-10 mg-12.5 mg

Usual Adult Dose for Helicobacter pylori Infection

Amoxicillin 250 mg-omeprazole 10 mg-rifabutin 12.5 mg oral capsules: 4 capsules orally every 8 hours

  • Duration of therapy: 14 days

  • Capsules should be swallowed with at least 8 ounces of water.
  • This drug should be used to treat infections proven/strongly suspected to be caused by susceptible bacteria.
  • Antibiotic selection should be determined by local bacterial resistance, duration of treatment, and appropriate use.

Use: Treatment of Helicobacter pylori infection

Renal Dose Adjustments

Mild to moderate renal dysfunction (Glomerular filtration rate [GFR] greater than 30 mL/min): Data not available
Severe renal dysfunction (GFR less than 30 mL/min): Not recommended.

Liver Dose Adjustments

Liver dysfunction (Child-Pugh Class A, B, and C): Not recommended.



  • Hypersensitivity to all the active components, any other rifamycins, other benzimidazoles (e.g., anthelmintics, proton pump inhibitors [PPIs]), other beta-lactam antibacterial drugs (e.g., cephalosporins, penicillins) or to any of the ingredients
  • Patients receiving delavirdine, rilpivirine-containing products, and/or voriconazole

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

  • This drug should be taken with meals.
  • Capsules should be swallowed whole, without crushing/chewing.
  • If patients miss a dose, the normal dosing schedule should be continued until this regimen is completed; patients should not take 2 doses to make up for the missed dose.

Storage requirements:
  • Protect from light and moisture.

  • Alcohol should be avoided during treatment.
  • Antacids may be taken with treatment.

  • HYPERSENSITIVITY: Signs/symptoms of hypersensitivity reactions
  • METABOLIC: Blood glucose (in patients at risk of hypoglycemia)
  • OCULAR: Signs/symptoms of uveitis (when used with macrolides or triazole antifungal agents)

Patient advice:
  • Patients should be advised to avoid missing doses and to complete the entire course of therapy.
  • Patients should be warned that treatment may produce a discoloration of sputum, sweat, tears, teeth, and urine; soft contact lenses may be permanently stained.
  • Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, acute interstitial nephritis, or systemic cutaneous lupus erythematosus occur.
  • Patients should be instructed to report signs/symptoms of Clostridium difficile (e.g., watery/bloody stools, stomach cramps, fever), for up to 2 months after stopping treatment.
  • Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.