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Aceon Side Effects

Generic name: perindopril

Medically reviewed by Drugs.com. Last updated on Feb 22, 2023.

Note: This document contains side effect information about perindopril. Some dosage forms listed on this page may not apply to the brand name Aceon.

Summary

Common side effects of Aceon include: cough. Continue reading for a comprehensive list of adverse effects.

Applies to perindopril: oral tablets.

Warning

  • May cause fetal and neonatal morbidity and mortality if used during pregnancy.1 42 43 (See Fetal/Neonatal Morbidity and Mortality under Cautions.)

  • If pregnancy is detected, discontinue perindopril as soon as possible.1 43

Side effects include:

Cough, proteinuria, palpitation, sinusitis, viral infection, dyspepsia, fever, upper extremity pain, hypertonia.

Dizziness reported at a rate similar to that with placebo, but incidence increases with increased dosage, suggesting causal relation to the drug.

For Healthcare Professionals

Applies to perindopril: oral tablet.

General

The most common adverse events were cough, dizziness, and back pain.[Ref]

Respiratory

Very common (10% or more): Cough (up to 12%)

Common (1% to 10%): Dyspnea, epistaxis

Uncommon (0.1% to 1%): Bronchospasm

Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness

Uncommon (0.1% to 1%): Somnolence, syncope

Very rare (less than 0.01%): Stroke[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Dry mouth

Very rare (less than 0.01%): Pancreatitis

Postmarketing reports: Acute pancreatitis[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation

Uncommon (0.1% to 1%): Tachycardia

Rare (0.01% to 0.1%): Sudden cardiac arrest

Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating

Very rare (less than 0.01%): Erythema multiforme

Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis[Ref]

Other

Common (1% to 10%): Asthenia, discomfort on exertion

Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain

Postmarketing reports: Serositis[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramps, back pain

Uncommon (0.1% to 1%): Arthralgia, myalgia[Ref]

Hepatic

Common (1% to 10%): ALT increased

Uncommon (0.1% to 1%): AST increased

Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased

Very rare (less than 0.01%): Hepatitis

Postmarketing reports: Hepatic failure, jaundice[Ref]

Ocular

Common (1% to 10%): Visual disturbances[Ref]

Renal

Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased

Very rare (less than 0.01%): Acute renal failure

Postmarketing reports: Nephritis[Ref]

Metabolic

Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia

Postmarketing reports: Symptomatic hyponatremia[Ref]

Hematologic

Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia

Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio

Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate[Ref]

Psychiatric

Uncommon (0.1% to 1%): Mood disturbances, sleep disorder

Very rare (less than 0.01%): Confusion, depression, hallucinations[Ref]

Genitourinary

Uncommon (0.1% to 1%): Erectile dysfunction[Ref]

Immunologic

Postmarketing reports: Positive antinuclear antibody[Ref]

References

1. "Product Information. Aceon (perindopril)." Solvay Pharmaceuticals Inc (2001):

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.