Aceon Side Effects

Generic name: perindopril

Medically reviewed by Drugs.com. Last updated on Feb 22, 2023.

Note: This document contains side effect information about perindopril. Some dosage forms listed on this page may not apply to the brand name Aceon.

Summary

Common side effects of Aceon include: cough. Continue reading for a comprehensive list of adverse effects.

Applies to perindopril: oral tablets.

Warning

May cause fetal and neonatal morbidity and mortality if used during pregnancy.¹ ⁴² ⁴³ (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
If pregnancy is detected, discontinue perindopril as soon as possible.¹ ⁴³

Side effects include:

Cough, proteinuria, palpitation, sinusitis, viral infection, dyspepsia, fever, upper extremity pain, hypertonia.

Dizziness reported at a rate similar to that with placebo, but incidence increases with increased dosage, suggesting causal relation to the drug.

For Healthcare Professionals

Applies to perindopril: oral tablet.

General

The most common adverse events were cough, dizziness, and back pain.^[Ref]

Respiratory

Very common (10% or more): Cough (up to 12%)

Common (1% to 10%): Dyspnea, epistaxis

Uncommon (0.1% to 1%): Bronchospasm

Very rare (less than 0.01%): Eosinophilic pneumonia, rhinitis^[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache, paresthesia, vertigo, tinnitus, dysgeusia, drowsiness

Uncommon (0.1% to 1%): Somnolence, syncope

Very rare (less than 0.01%): Stroke^[Ref]

Gastrointestinal

Common (1% to 10%): Abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting

Uncommon (0.1% to 1%): Dry mouth

Very rare (less than 0.01%): Pancreatitis

Postmarketing reports: Acute pancreatitis^[Ref]

Cardiovascular

Common (1% to 10%): Hypotension, palpitations, vasculitis, flushing, impaired peripheral circulation

Uncommon (0.1% to 1%): Tachycardia

Rare (0.01% to 0.1%): Sudden cardiac arrest

Very rare (less than 0.01%): Angina pectoris, arrhythmia, myocardial infarction^[Ref]

Dermatologic

Common (1% to 10%): Pruritus, rash

Uncommon (0.1% to 1%): Urticaria, angioedema, photosensitivity reactions, pemphigoid, hyperhidrosis, eczema, sweating

Very rare (less than 0.01%): Erythema multiforme

Postmarketing reports: Bullous pemphigoid, pemphigus, psoriasis, exfoliative dermatitis^[Ref]

Other

Common (1% to 10%): Asthenia, discomfort on exertion

Uncommon (0.1% to 1%): Chest pain, malaise, edema peripheral, pyrexia, fall, atypical chest pain

Postmarketing reports: Serositis^[Ref]

Musculoskeletal

Common (1% to 10%): Muscle cramps, back pain

Uncommon (0.1% to 1%): Arthralgia, myalgia^[Ref]

Hepatic

Common (1% to 10%): ALT increased

Uncommon (0.1% to 1%): AST increased

Rare (0.01% to 0.1%): Blood bilirubin increased, hepatic enzyme increased

Very rare (less than 0.01%): Hepatitis

Postmarketing reports: Hepatic failure, jaundice^[Ref]

Ocular

Common (1% to 10%): Visual disturbances^[Ref]

Renal

Uncommon (0.1% to 1%): Renal insufficiency, blood urea increased, blood creatinine increased

Very rare (less than 0.01%): Acute renal failure

Postmarketing reports: Nephritis^[Ref]

Metabolic

Uncommon (0.1% to 1%): Hypoglycemia, hyperkalemia, hyponatremia

Postmarketing reports: Symptomatic hyponatremia^[Ref]

Hematologic

Uncommon (0.1% to 1%): Eosinophilia, leukopenia/neutropenia

Very rare (less than 0.01%): Agranulocytosis or pancytopenia, hemoglobin decreased and hematocrit decreased, hemolytic anemia in patients with a congenital deficiency of glucose-6-phosphate dehydrogenase, thrombocytopenia, unexplained change in prothrombin ratio

Postmarketing reports: Anemia, leukocytosis, elevated erythrocyte sedimentation rate^[Ref]