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AbobotulinumtoxinA Side Effects

Medically reviewed by Last updated on Dec 10, 2023.

Applies to abobotulinumtoxinA: intramuscular powder for solution.


Intramuscular route (Powder for Solution)

The effects of abobotulinumtoxinA and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms.

Serious side effects of AbobotulinumtoxinA

Along with its needed effects, abobotulinumtoxinA may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking abobotulinumtoxinA:

More common

Less common

Incidence not known

Other side effects of AbobotulinumtoxinA

Some side effects of abobotulinumtoxinA may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

Incidence not known

For Healthcare Professionals

Applies to abobotulinumtoxinA: injectable powder for injection, intramuscular powder for injection.


The most commonly occurring side effects have included muscular weakness, dysphagia, dry mouth, injection site pain and discomfort, fatigue, headache, and nasopharyngitis.

Nervous system

Very common (10% or more): Dysphonia (up to 28%), headache (11%), facial paresis (up to 11%)

Common (1% to 10%): Dizziness, convulsion, syncope, hypoesthesia, partial seizures[Ref]


Common (1% to 10%): Hypertension, peripheral edema[Ref]


Very common (10% or more): Dysphagia (up to 39%), dry mouth (up to 39%)

Common (1% to 10%): Nausea, diarrhea, constipation, vomiting, gastroenteritis[Ref]


Common (1% to 10%): Urinary tract infection, blood present in urine[Ref]


Uncommon (0.1% to 1%): Abnormal liver function tests[Ref]


Rare (less than 0.1%): Anaphylaxis, urticaria, soft tissue edema

Postmarketing reports: Hypersensitivity reactions including anaphylaxis[Ref]


Frequency not reported: Blood triglycerides increased[Ref]


Very common (10% or more): Eye disorders (e.g., vision blurred, diplopia, visual acuity reduced, eye pain, eyelid disorder, accommodation disorder, dry eye, eye pruritus) (up to 17%)

Common (1% to 10%): Eyelid edema, eyelid ptosis

Postmarketing reports: Photophobia[Ref]


Very common (10% or more): Injection site discomfort (e.g., pain, bruising, hemorrhage, injection site erythema/hematoma) (up to 22%)

Common (1% to 10%): Injection site pain[Ref]


Very common (10% or more): Nasopharyngitis (10%), upper respiratory infection (10%)

Common (1% to 10%): Breathing difficulty, dyspnea, sinusitis, cough, pharyngitis, bronchitis, rhinitis, oropharyngeal pain[Ref]


Very common (10% or more): Muscular weakness (up to 56%)

Common (1% to 10%): Musculoskeletal pain, muscle atrophy, pain in extremity, back pain, wrist fracture

Uncommon (0.1% to 1%): Gait disturbance, hypertonia

Postmarketing reports: Amyotrophy[Ref]


Common (1% to 10%): Infection, influenza, neutralizing antibodies[Ref]


Frequency not reported: Excessive granulation tissue, erythema[Ref]


Very common (10% or more): Fatigue (12%)

Common (1% to 10%): Fall, injury, contusion, ear infection, pyrexia

Uncommon (0.1% to 1%): Sensation of heaviness

Frequency not reported: Distant spread of toxin effects

Postmarketing reports: Vertigo, burning sensation, hypoesthesia


Common (1% to 10%): Depression, insomnia[Ref]

Frequently asked questions


1. Product Information. Dysport (abobotulinumtoxinA). Tercica Inc. PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.