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Zetran (injection)

Generic Name: diazepam (injection) (dye AZ e pam)
Brand Name: Valium, Zetran

Medically reviewed on Mar 2, 2017

The Zetran brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

What is Zetran?

Zetran is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). This medicine affects chemicals in the brain that may be unbalanced in people with certain conditions.

Zetran is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. This medicine injection is also used to treat a seizure emergency called status epilepticus.

Zetran is sometimes used as a sedative to help you relax before having surgery or other medical procedure.

Zetran may also be used for purposes not listed in this medication guide.

Important Information

You should not receive Zetran if you have narrow-angle glaucoma, or untreated open-angle glaucoma.

Using Zetran with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Tell your doctor if you regularly use a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Do not drink alcohol shortly after receiving Zetran. Dangerous side effects or death could occur.

Before taking this medicine

You should not be treated with Zetran if you are allergic to it, or if you have:

  • narrow-angle glaucoma; or

  • untreated open-angle glaucoma.

To make sure Zetran is safe for you, tell your doctor if you have:

  • a history of glaucoma;

  • asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

  • kidney or liver disease;

  • a history of mental illness, depression, or suicidal thoughts or behavior;

  • heart disease; or

  • if you have recently used alcohol, sedatives, tranquilizers, or narcotic (opioid) medications.

Zetran can cause birth defects in an unborn baby, and generally should not be used during pregnancy. However, status epilepticus is a life-threatening condition and the benefit of receiving this medicine to treat it may outweigh any risk to the unborn baby.

Diazepam can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

In an emergency situation, it may not be possible before you are treated with Zetran to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is Zetran given?

Zetran is injected into a muscle, or into a vein through an IV. You will receive this injection in a medical or surgical setting. This medicine injection is for short-term use only.

Zetran is usually given as a single dose just before a surgery or medical procedure. For other conditions, Zetran is usually given until you are able to take medicine by mouth.

You may need to receive only one dose of diazepam if your condition improves after the medicine is given.

When injected into a vein, Zetran must be given slowly. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when this medicine is injected.

After treatment with Zetran, you will be watched to make sure the medication is working and does not cause harmful side effects.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are in surgery.

Zetran can make you very drowsy, dizzy, or light-headed. These effects may last longer in older adults. Use caution to avoid falling or accidental injury after you have received this medicine. You may need help getting out of bed for at least the first several hours.

What happens if I miss a dose?

Because you will receive Zetran in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Zetran?

Do not drink alcohol shortly after receiving Zetran. Dangerous side effects or death could occur.

Zetran can cause extreme drowsiness that may last for several hours after you have received the medication. Older adults may feel sleepy for even longer.

Avoid driving or doing anything that requires you to be awake and alert until the effects of Zetran have worn off completely.

Zetran side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • weak or shallow breathing;

  • restlessness, feeling agitated or irritable;

  • unusual thoughts, hallucinations; or

  • a light-headed feeling, like you might pass out.

The sedative effects of diazepam may last longer in older adults. Accidental falls are common in elderly patients who use benzodiazepines. Use caution to avoid falling or accidental injury shortly after receiving Zetran.

Common side effects may include:

  • drowsiness;

  • tired feeling;

  • muscle weakness, loss of coordination; or

  • bruising or swelling around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zetran?

Shortly after you are treated with Zetran, taking other drugs that make you sleepy or slow your breathing can cause dangerous side effects. Tell your doctor if you regularly use a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with diazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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