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Generic name: methocarbamol (oral/injection) [ meth-oh-KAR-ba-mal ]
Brand names: Robaxin, Robaxin-750
Drug class: Skeletal muscle relaxants

Medically reviewed by on Aug 4, 2023. Written by Cerner Multum.

What is Robaxin-750?

Robaxin-750 is a muscle relaxer that is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Robaxin-750 injection is sometimes used in the treatment of tetanus, (lockjaw) which causes painful tightening of the muscles.

Robaxin-750 may also be used for purposes not listed in this medication guide.

Robaxin-750 side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Robaxin-750 may cause serious side effects. Stop using Robaxin-750 and call your doctor at once if you have:

Common side effects of Robaxin-750 may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Robaxin-750 if you are allergic to it.

Tell your doctor if you have ever had:

Robaxin-750 may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

It may not be safe to breastfeed while using Robaxin-750. Ask your doctor about any risk.

Robaxin-750 is not approved for use by anyone younger than 16 years old unless to treat tetanus.

How should I use Robaxin-750?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. Robaxin-750 is only part of a complete treatment program that may also include rest, physical therapy, or other pain relief measures.

Robaxin-750 oral is taken by mouth. You may need to reduce your dose after the first 2 or 3 days of treatment. Carefully follow your doctor's dosing instructions.

Robaxin-750 injection is injected into a muscle or given as an infusion into a vein. A healthcare provider will give you this injection.

Robaxin-750 injection is usually given as a single dose before you start taking the oral form.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Robaxin-750 is injected.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Robaxin-750.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, extreme drowsiness, fainting, seizure, or coma.

What should I avoid while taking Robaxin-750?

Avoid driving or hazardous activity until you know how Robaxin-750 will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Drinking alcohol with this medicine can cause side effects.

What other drugs will affect Robaxin-750?

Using Robaxin-750 with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Other drugs may affect Robaxin-750, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

When taken by mouth, it takes methocarbamol about 30 minutes to start working. It is usually taken 4 times a day to relax muscles and ease pain and discomfort.

Methocarbamol does not come with a label warning regarding abuse, addiction or dependency. Human studies regarding abuse have provided mixed results, so the answer remains unclear. It may have abuse potential. It can also cause problems if it’s taken with other drugs that have abuse potential, such as alcohol, benzodiazepines, opioids and central nervous system depressants.

Methocarbamol is not labeled as a controlled substance by the U.S. Drug Enforcement Administration (DEA). However, there is some evidence that methocarbamol may have abuse potential. It should be used with caution in patients taking other drugs with abuse potential, such as alcohol and drugs that treat sleep disorders.

Yes, methocarbamol can cause sleepiness. It may affect your ability to think or to do physical abilities such as operating machinery or driving a motor vehicle. While taking methocarbamol, you should avoid taking other drugs that have similar effects, such as alcohol and medicines that treat sleep disorders.

There is no known drug interaction between methocarbamol and non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac. You may take methocarbamol and diclofenac together. Because it may cause drowsiness or dizziness, methocarbamol interacts with other drugs that have similar effects, such as alcohol and drugs that treat sleep disorders.

Methocarbamol is not known to cause weight gain. The most common side effects of methocarbamol are drowsiness or dizziness. It can also cause headaches in some people.

Common antidepressants used for orthopedic pain relief may include SSRIs like fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), SNRIs such as duloxetine (Cymbalta), or tricyclic antidepressants (TCAs) like amitriptyline (Elavil) or nortriptyline (Pamelor). Continue reading

Ardosons is a medicine reported as being from Mexico that may contain 25 mg of indomethacin (in Spanish called "indometacina"), 0.75 mg of betamethasone ("betametasona") and 215 mg of methocarbamol ("metocarbamol") per capsule. There is no FDA-approved oral combination product in the U.S. that is equivalent to Ardosons. The safety and effectiveness of imported online drugs have not been reviewed by the FDA and their identity and potency can't be assured. Continue reading

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.