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Navane

Generic Name: thiothixene (THYE oh THIX een)
Brand Name: Navane

Medically reviewed by Drugs.com on Sep 26, 2018 – Written by Cerner Multum

What is Navane?

Navane is an antipsychotic medication. It affects the actions of chemicals in your brain.

Navane is used to treat schizophrenia.

Navane may also be used for purposes not listed in this medication guide.

Important Information

Navane is not approved for use in psychotic conditions related to dementia. This medicine may increase the risk of death in older adults with dementia-related conditions.

You should not use Navane if you have a blood cell disorder, or if you have drowsiness, slow breathing, weak pulse, or decreased alertness (such as after drinking alcohol or taking medicines that make you sleepy).

Before taking this medicine

You should not use Navane if you are allergic to it, or if you have:

  • a blood cell disorder such as anemia, low white blood cell counts, or low platelets; or

  • drowsiness, slow breathing, weak pulse, or decreased alertness (such as after drinking alcohol or taking medicines that make you sleepy).

Navane is not approved for use in psychotic conditions related to dementia. This medicine may increase the risk of death in older adults with dementia-related conditions.

Long-term use of thiothixene can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take Navane, the more likely you are to develop this movement disorder. The risk of this side effect is higher in women and older adults.

To make sure Navane is safe for you, tell your doctor if you have:

  • epilepsy or other seizure disorder;

  • heart disease;

  • a history of low white blood cell (WBC) counts;

  • a history of breast cancer; or

  • if you are addicted to alcohol.

Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Navane, do not stop taking it without your doctor's advice.

It is not known whether thiothixene passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Navane should not be given to a child younger than 12 years old.

How should I take Navane?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take Navane in larger or smaller amounts or for longer than recommended.

You may not start feeling better right away when you start taking Navane. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve during treatment.

You will need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include drowsiness, dizziness, muscle stiffness or twitching, increased salivation, trouble swallowing, weakness, loss of balance or coordination, and fainting.

What should I avoid while taking Navane?

Navane may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. Dangerous side effects could occur.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Navane can decrease perspiration and you may be more prone to heat stroke.

Avoid exposure to sunlight or tanning beds. Navane can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Navane side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Navane and call your doctor at once if you have:

  • twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

  • stiffness in your neck, tightness in your throat, trouble breathing or swallowing;

  • seizure (convulsions);

  • sudden weakness or ill feeling, fever, chills, sore throat, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, easy bruising or bleeding;

  • a light-headed feeling, like you might pass out;

  • severe constipation;

  • pale or yellowed skin, dark colored urine, confusion; or

  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Older adults may be more likely to have side effects from Navane.

Common side effects may include:

  • dry mouth, increased thirst;

  • blurred vision, drowsiness;

  • nausea, vomiting, diarrhea, constipation;

  • fast heart rate, restless feeling;

  • breast swelling or discharge;

  • changes in weight or appetite; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Navane?

Taking Navane with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Other drugs may interact with thiothixene, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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